The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 157: Mitogen-activated protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
5 Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
5 Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q00772 (/IPI) Q00772 (/IPI) Q00772 (/IPI) Q00772 (/IPI) Q00772 (/IPI)
MAP kinase activity GO:0004707
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2 Q5AAG6 (/IGI) Q5AAG6 (/IGI)

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
8 Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q5AAG6 (/IMP) Q5AAG6 (/IMP) Q6FPV9 (/IMP) Q6FPV9 (/IMP)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
7 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q6FPV9 (/IMP) Q6FPV9 (/IMP)
Regulation of fungal-type cell wall organization GO:0060237
Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
7 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q5AAG6 (/IMP) Q5AAG6 (/IMP)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
6 Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q5AAG6 (/IMP) Q5AAG6 (/IMP)
Cell wall integrity MAPK cascade GO:0000196
A MAPK cascade that contributes to cell wall organization or biogenesis.
5 Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
5 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
5 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP)
Fungal-type cell wall biogenesis GO:0009272
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin.
5 Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI)
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
5 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP)
Positive regulation of division septum assembly GO:0010973
Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
5 Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI)
Autophagy of peroxisome GO:0030242
The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions.
5 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP)
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
5 Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA)
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
5 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP)
IRE1-mediated unfolded protein response GO:0036498
A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
5 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP)
Regulation of protein import into nucleus GO:0042306
Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.
5 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP)
Regulation of fungal-type cell wall organization GO:0060237
Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
5 Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI) Q00772 (/IGI)
Regulation of proteasome assembly GO:0090364
Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex.
5 Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP) Q00772 (/IMP)
Hyphal growth GO:0030448
Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
4 Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP)
Regulation of melanin biosynthetic process GO:0048021
Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
4 Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP)
Cellular heat acclimation GO:0070370
Any process that increases heat tolerance of a cell in response to high temperatures.
4 Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP)
Cellular response to alkaline pH GO:0071469
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.
4 Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP)
Fungal-type cell wall organization or biogenesis GO:0071852
A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall.
4 Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP) Q4WQR3 (/IMP)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
2 Q6FPV9 (/IMP) Q6FPV9 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 Q5AAG6 (/IGI) Q5AAG6 (/IGI)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 Q5AAG6 (/IGI) Q5AAG6 (/IGI)
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
2 Q6FPV9 (/IMP) Q6FPV9 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
2 Q5AAG6 (/IMP) Q5AAG6 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
2 Q5AAG6 (/IMP) Q5AAG6 (/IMP)
Stress-activated protein kinase signaling cascade GO:0031098
A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.
2 Q5AAG6 (/IEP) Q5AAG6 (/IEP)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
2 Q5AAG6 (/IGI) Q5AAG6 (/IGI)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
2 Q5AAG6 (/IMP) Q5AAG6 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q5AAG6 (/IMP) Q5AAG6 (/IMP)
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
2 Q5AAG6 (/IMP) Q5AAG6 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
2 Q5AAG6 (/IMP) Q5AAG6 (/IMP)
Single-species biofilm formation on inanimate substrate GO:0044011
A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
2 Q5AAG6 (/IMP) Q5AAG6 (/IMP)
Regulation of single-species biofilm formation on inanimate substrate GO:1900231
Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
2 Q5AAG6 (/IMP) Q5AAG6 (/IMP)
Positive regulation of filamentous growth of a population of unicellular organisms in response to starvation GO:1900436
Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation.
2 Q5AAG6 (/IMP) Q5AAG6 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA) Q00772 (/HDA)
Cellular bud tip GO:0005934
The end of a cellular bud distal to the site of attachment to the mother cell.
5 Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
5 Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA)
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
5 Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA) Q00772 (/IDA)