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CATH Superfamily 3.30.200.20

Phosphorylase Kinase; domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 138: Phosphorylase b kinase gamma catalytic chain, live...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphorylase kinase. [EC: 2.7.11.19]
2 ATP + phosphorylase b = 2 ADP + phosphorylase a.
  • Requires calmodulin for activity.
  • The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b.
  • For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase.
  • The enzyme couples muscle contraction with energy production via glycogenolysis--glycolysis by catalyzing the Ca(2+)-dependent phosphorylation and activation of glycogen phosphorylase b.
  • The gamma subunit of the tetrameric alpha-beta-gamma-delta enzyme is the catalytic subunit.
  • Formerly EC 2.7.1.38.
 17 A0A024RDL4 A0A024RDL4 A0A1W6R6B8 A0A1W6R6B8 L8IXM6 L8IXM6 P00518 P07934 P07934 P13286
(7 more...)
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 10 A0A024RDL4 A0A024RDL4 A0A1W6R6B8 A0A1W6R6B8 P00518 P07934 P07934 P13286 Q16816 Q16816
[Tau protein] kinase. [EC: 2.7.11.26]
ATP + [tau protein] = ADP + [tau protein] phosphate.
  • Activated by tubulin.
  • Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
  • Formerly EC 2.7.1.135.
 10 A0A024RDL4 A0A024RDL4 A0A1W6R6B8 A0A1W6R6B8 P00518 P07934 P07934 P13286 Q16816 Q16816