The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SIR2/SIRT2 'Small Domain'
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: SIR2 family histone deacetylase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
NAD-dependent histone deacetylase activity GO:0017136
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.
3 P53687 (/IDA) P53688 (/IDA) P53688 (/IDA)
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
1 Q5A1W9 (/IMP)
NAD-dependent histone deacetylase activity GO:0017136
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.
1 P53687 (/IMP)
NAD-dependent histone deacetylase activity GO:0017136
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.
1 Q9UR39 (/ISO)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of penicillin catabolic process GO:0033248
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
4 Q2U2P7 (/IMP) Q2U2P7 (/IMP) Q2U2P7 (/IMP) Q2U2P7 (/IMP)
Negative regulation of kojic acid biosynthetic process GO:1900395
Any process that stops, prevents or reduces the frequency, rate or extent of kojic acid biosynthetic process.
4 Q2U2P7 (/IMP) Q2U2P7 (/IMP) Q2U2P7 (/IMP) Q2U2P7 (/IMP)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
3 P53687 (/IGI) P53688 (/IGI) P53688 (/IGI)
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
3 P53687 (/IGI) P53688 (/IGI) P53688 (/IGI)
Short-chain fatty acid metabolic process GO:0046459
The chemical reactions and pathways involving fatty acids with a chain length of less than C6.
3 P53687 (/IMP) P53688 (/IMP) P53688 (/IMP)
Replication-born double-strand break repair via sister chromatid exchange GO:1990414
The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.
3 P53687 (/IMP) P53688 (/IMP) P53688 (/IMP)
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
2 P53687 (/IMP) Q9UR39 (/IMP)
Histone H3-K56 deacetylation GO:0071572
The modification of histone H3 by the removal of an acetyl group from lysine at position 56 of the histone.
2 Q5A1W9 (/IMP) Q9UR39 (/IMP)
Cellular response to biotin starvation GO:1990383
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of biotin.
2 P53688 (/IMP) P53688 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9UR39 (/IMP)
Regulation of DNA repair GO:0006282
Any process that modulates the frequency, rate or extent of DNA repair.
1 Q9UR39 (/IMP)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
1 Q9UR39 (/IMP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 Q9UR39 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5A1W9 (/IMP)
Chromatin silencing at centromere GO:0030702
Repression of transcription of centromeric DNA by altering the structure of chromatin.
1 Q9UR39 (/IMP)
Pericentric heterochromatin assembly GO:0031508
The assembly of chromatin into heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
1 Q9UR39 (/EXP)
Phenotypic switching GO:0036166
A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
1 Q5A1W9 (/IMP)
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5A1W9 (/IMP)
Regulation of nucleosome density GO:0060303
Any process that modulates the number of nucleosomes in a given region of a chromosome.
1 Q9UR39 (/IEP)
Regulation of phenotypic switching GO:1900239
Any process that modulates the frequency, rate or extent of phenotypic switching.
1 Q5A1W9 (/IMP)
Negative regulation of filamentous growth of a population of unicellular organisms GO:1900429
Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms.
1 Q5A1W9 (/IMP)
Histone H4-K16 deacetylation GO:1990678
The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone.
1 Q9UR39 (/IMP)
Histone H4-K12 deacetylation GO:1990679
The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone.
1 Q9UR39 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P53688 (/HDA) P53688 (/HDA) Q9UR39 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P53688 (/IDA) P53688 (/IDA) Q9UR39 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P53688 (/HDA) P53688 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P53688 (/IDA) P53688 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P53688 (/IDA) P53688 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q9UR39 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P53687 (/IC)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9UR39 (/IDA)
Nuclear pericentric heterochromatin GO:0031618
Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
1 Q9UR39 (/IDA)
Mating-type region heterochromatin GO:0031934
Heterochromatic regions of the chromosome found at silenced mating-type loci.
1 Q9UR39 (/IDA)
Nuclear rDNA heterochromatin GO:1902377
Any rDNA heterochromatin that is part of a nucleus.
1 Q9UR39 (/IDA)
Nuclear subtelomeric heterochromatin GO:1990707
Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus.
1 Q9UR39 (/IDA)