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CATH Superfamily 3.30.160.70

Methylated DNA-protein cysteine methyltransferase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Methylated DNA-protein cysteine methyltransferase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Bifunctional transcriptional activator/DNA repair ...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Methylated-DNA--[protein]-cysteine S-methyltransferase. [EC: 2.1.1.63]
(1) DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. (2) DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine.
  • This protein is involved in the repair of methylated DNA.
  • Unlike EC 3.2.2.20 and EC 3.2.2.21, which remove the methylated base leaving an apurinic/apyrimidinic site, this enzyme transfers the methyl group from the methylated DNA to an internal cysteine residue, leaving an intact nucleotide.
  • Since the methyl transfer is irreversible, the enzyme can only catalyze a single turnover.
 529 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9
(519 more...)
Methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase. [EC: 2.1.1.n11]
DNA (containing Sp-methylphosphotriester) + protein L-cysteine = DNA (without Sp-methylphosphotriester) + protein S-methyl-L-cysteine.
  • This protein is involved in the repair of Sp diastereomers of DNA methylphosphotriester lesions.
  • This enzyme catalyzes only one turnover and therefore is not strictly catalytic.
  • The enzyme from the bacterium Escherichia coli also has the activity of EC 2.1.1.63 while the enzyme from Bacillus subtilis does not.
 529 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9 A0A069XUR9
(519 more...)