The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 91: Putative Krueppel-like factor 12

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
29 O35738 (/IPI) P57682 (/IPI) P57682 (/IPI) P57682 (/IPI) P57682 (/IPI) P57682 (/IPI) P57682 (/IPI) P57682 (/IPI) P57682 (/IPI) P57682 (/IPI)
(19 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
28 P57682 (/ISA) P57682 (/ISA) P57682 (/ISA) P57682 (/ISA) P57682 (/ISA) P57682 (/ISA) P57682 (/ISA) P57682 (/ISA) P57682 (/ISA) P57682 (/ISA)
(18 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
15 P57682 (/NAS) P57682 (/NAS) P57682 (/NAS) P57682 (/NAS) P57682 (/NAS) P57682 (/NAS) P57682 (/NAS) P57682 (/NAS) P57682 (/NAS) P57682 (/NAS)
(5 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
14 O35738 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA)
(4 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
14 O35738 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA)
(4 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
13 Q9Y4X4 (/NAS) Q9Y4X4 (/NAS) Q9Y4X4 (/NAS) Q9Y4X4 (/NAS) Q9Y4X4 (/NAS) Q9Y4X4 (/NAS) Q9Y4X4 (/NAS) Q9Y4X4 (/NAS) Q9Y4X4 (/NAS) Q9Y4X4 (/NAS)
(3 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
13 Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS)
(3 more)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
13 Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS)
(3 more)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 A2BG67 (/IDA) O35738 (/IDA) Q6NYD5 (/IDA) Q90XE9 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
3 O35738 (/IDA) Q60980 (/IDA) Q60980 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 O35738 (/ISS) Q60980 (/ISS) Q60980 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
3 A2BG67 (/IDA) Q6NYD5 (/IDA) Q90XE9 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q60980 (/IC) Q60980 (/IC)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 O35738 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 O35738 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
15 P57682 (/TAS) P57682 (/TAS) P57682 (/TAS) P57682 (/TAS) P57682 (/TAS) P57682 (/TAS) P57682 (/TAS) P57682 (/TAS) P57682 (/TAS) P57682 (/TAS)
(5 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
14 O35738 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA)
(4 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
13 Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS) Q9Y4X4 (/TAS)
(3 more)
Erythrocyte maturation GO:0043249
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
3 A2BG67 (/IMP) Q6NYD5 (/IMP) Q90XE9 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q60980 (/IMP) Q60980 (/IMP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2 A0A2R8QT61 (/IMP) A0S0R1 (/IMP)
Cerebellar Purkinje cell differentiation GO:0021702
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.
2 A0A2R8QT61 (/IMP) A0S0R1 (/IMP)
Cerebellar granule cell differentiation GO:0021707
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
2 A0A2R8QT61 (/IMP) A0S0R1 (/IMP)
Establishment of left/right asymmetry GO:0061966
The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves.
2 A0A2R8QT61 (/IMP) A0S0R1 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O35738 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 O35738 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O35738 (/IDA)
Cellular response to peptide GO:1901653
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
1 D4A4V3 (/IEP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
43 A0A024R9T8 (/IDA) A0A024R9T8 (/IDA) A0A024R9T8 (/IDA) A0A024R9T8 (/IDA) A0A024R9T8 (/IDA) A0A024R9T8 (/IDA) A0A024R9T8 (/IDA) A0A024R9T8 (/IDA) A0A024R9T8 (/IDA) A0A024R9T8 (/IDA)
(33 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA) Q9Y4X4 (/IDA)
(3 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 O35738 (/ISO) Q60980 (/ISO) Q60980 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O35738 (/ISO)