The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 757: Transcription factor Msn2p

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
8 P33748 (/IDA) P33748 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
8 P33748 (/IMP) P33748 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP)
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
8 P33748 (/IDA) P33748 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P33748 (/IPI) P33748 (/IPI) P33749 (/IPI) P33749 (/IPI) P33749 (/IPI) P33749 (/IPI) P33749 (/IPI) P33749 (/IPI)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Replicative cell aging GO:0001302
The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Age-dependent response to oxidative stress involved in chronological cell aging GO:0001324
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation GO:0036278
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance GO:0061395
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment GO:0061401
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to acidic pH GO:0061402
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to acidic pH GO:0061402
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7.
8 P33748 (/IMP) P33748 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress GO:0061403
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to increased salt GO:0061404
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure GO:0061405
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation GO:0061406
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of glucose.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide GO:0061407
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide GO:0061407
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus.
8 P33748 (/IMP) P33748 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to heat stress GO:0061408
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
8 P33748 (/IMP) P33748 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to freezing GO:0061409
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a freezing stimulus, temperatures below 0 degrees Celsius.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to ethanol GO:0061410
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to cold GO:0061411
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation GO:0061412
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of amino acids.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH GO:0061422
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction GO:0061434
Any process that modulates the frequency, rate or extent of replicative cell aging through a mechanism that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a caloric restriction stimulus.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation GO:0097236
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of zinc ions.
8 P33748 (/IGI) P33748 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter in response to heat stress GO:0061408
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
6 P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI) P33749 (/IGI)
Cellular response to acidic pH GO:0071468
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
6 P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP) P33749 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q6FIM7 (/IMP) Q6FU62 (/IMP)
Cellular response to methylmercury GO:0071406
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus.
2 P33748 (/IGI) P33748 (/IGI)
Cellular response to methylmercury GO:0071406
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus.
2 P33748 (/IMP) P33748 (/IMP)
Cellular response to blue light GO:0071483
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.
2 P33748 (/IDA) P33748 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 K4H1X2 (/IDA) P33748 (/IDA) P33748 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) Q6FIM7 (/IDA)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P33748 (/IDA) P33748 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) P33749 (/IDA) Q6FIM7 (/IDA) Q6FU62 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P33748 (/HDA) P33748 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P33748 (/HDA) P33748 (/HDA)