The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 673: Zinc finger and BTB domain-containing 7B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 P07247 (/IDA) P07247 (/IDA) Q64321 (/IDA) Q64321 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O15156 (/IPI) O15156 (/IPI) Q64321 (/IPI) Q64321 (/IPI)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
2 Q64321 (/IDA) Q64321 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P07247 (/IDA) P07247 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 O15156 (/ISA) O15156 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 O15156 (/NAS) O15156 (/NAS)
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
2 Q64321 (/IMP) Q64321 (/IMP)
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
2 O15156 (/ISS) O15156 (/ISS)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q64321 (/IDA) Q64321 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q64321 (/IDA) Q64321 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q64321 (/IDA) Q64321 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q64321 (/IPI) Q64321 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 O15156 (/ISS) O15156 (/ISS)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
2 Q64321 (/IPI) Q64321 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 P07247 (/IDA) P07247 (/IDA)

There are 63 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
3 D4A579 (/ISS) O15156 (/ISS) O15156 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P07247 (/IDA) P07247 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q64321 (/IMP) Q64321 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 O15156 (/ISS) O15156 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P07247 (/TAS) P07247 (/TAS)
NK T cell differentiation GO:0001865
The process in which a precursor cell type acquires the specialized features of a NK T cell.
2 Q64321 (/IMP) Q64321 (/IMP)
NK T cell differentiation GO:0001865
The process in which a precursor cell type acquires the specialized features of a NK T cell.
2 O15156 (/ISS) O15156 (/ISS)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
2 P07247 (/IMP) P07247 (/IMP)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
2 O15156 (/TAS) O15156 (/TAS)
Zygotic determination of anterior/posterior axis, embryo GO:0007354
The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade.
2 P07247 (/NAS) P07247 (/NAS)
Zygotic determination of anterior/posterior axis, embryo GO:0007354
The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade.
2 P07247 (/TAS) P07247 (/TAS)
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
2 O15156 (/TAS) O15156 (/TAS)
Neuroblast fate determination GO:0007400
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.
2 P07247 (/IEP) P07247 (/IEP)
Neuroblast fate determination GO:0007400
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.
2 P07247 (/IMP) P07247 (/IMP)
Ganglion mother cell fate determination GO:0007402
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed.
2 P07247 (/TAS) P07247 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 P07247 (/IMP) P07247 (/IMP)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
2 P07247 (/NAS) P07247 (/NAS)
Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
2 P07247 (/TAS) P07247 (/TAS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
2 P07247 (/TAS) P07247 (/TAS)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
2 Q64321 (/IMP) Q64321 (/IMP)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
2 O15156 (/ISS) O15156 (/ISS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q64321 (/IMP) Q64321 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q64321 (/IDA) Q64321 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 O15156 (/ISS) O15156 (/ISS)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q64321 (/IDA) Q64321 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q64321 (/IMP) Q64321 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 O15156 (/ISS) O15156 (/ISS)
Positive regulation of histone deacetylation GO:0031065
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
2 Q64321 (/IMP) Q64321 (/IMP)
Positive regulation of histone deacetylation GO:0031065
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
2 O15156 (/ISS) O15156 (/ISS)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 Q64321 (/IMP) Q64321 (/IMP)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 O15156 (/ISS) O15156 (/ISS)
Regulation of hemocyte proliferation GO:0035206
Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
2 P07247 (/IMP) P07247 (/IMP)
Trunk segmentation GO:0035290
Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8.
2 P07247 (/TAS) P07247 (/TAS)
Regulation of development, heterochronic GO:0040034
Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.
2 P07247 (/NAS) P07247 (/NAS)
Regulation of development, heterochronic GO:0040034
Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.
2 P07247 (/TAS) P07247 (/TAS)
Regulation of CD4-positive, alpha-beta T cell differentiation GO:0043370
Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.
2 Q64321 (/IMP) Q64321 (/IMP)
Positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372
Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.
2 Q64321 (/IMP) Q64321 (/IMP)
Positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372
Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.
2 O15156 (/ISS) O15156 (/ISS)
Regulation of CD8-positive, alpha-beta T cell differentiation GO:0043376
Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation.
2 Q64321 (/IMP) Q64321 (/IMP)
Negative regulation of CD8-positive, alpha-beta T cell differentiation GO:0043377
Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation.
2 Q64321 (/IMP) Q64321 (/IMP)
Negative regulation of CD8-positive, alpha-beta T cell differentiation GO:0043377
Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation.
2 O15156 (/ISS) O15156 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P07247 (/IDA) P07247 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q64321 (/IDA) Q64321 (/IDA)
Positive regulation of insulin receptor signaling pathway GO:0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
2 Q64321 (/IMP) Q64321 (/IMP)
Positive regulation of insulin receptor signaling pathway GO:0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
2 O15156 (/ISS) O15156 (/ISS)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
2 P07247 (/IMP) P07247 (/IMP)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
2 P07247 (/IMP) P07247 (/IMP)
Negative regulation of NK T cell proliferation GO:0051141
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation.
2 Q64321 (/IMP) Q64321 (/IMP)
Negative regulation of NK T cell proliferation GO:0051141
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation.
2 O15156 (/ISS) O15156 (/ISS)
Regulation of transcription involved in cell fate commitment GO:0060850
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate.
2 Q64321 (/IMP) Q64321 (/IMP)
Regulation of transcription involved in cell fate commitment GO:0060850
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate.
2 O15156 (/ISS) O15156 (/ISS)
Malpighian tubule bud morphogenesis GO:0061332
The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position.
2 P07247 (/IGI) P07247 (/IGI)
Interleukin-17 secretion GO:0072615
The regulated release of any member of the interleukin-17 family of cytokines from a cell.
2 Q64321 (/IMP) Q64321 (/IMP)
Interleukin-17 secretion GO:0072615
The regulated release of any member of the interleukin-17 family of cytokines from a cell.
2 O15156 (/ISS) O15156 (/ISS)
Positive regulation of brown fat cell differentiation GO:0090336
Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
2 Q64321 (/IMP) Q64321 (/IMP)
Positive regulation of brown fat cell differentiation GO:0090336
Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
2 O15156 (/ISS) O15156 (/ISS)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
2 Q64321 (/IMP) Q64321 (/IMP)
Adaptive thermogenesis GO:1990845
The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.
2 Q64321 (/IMP) Q64321 (/IMP)
Adaptive thermogenesis GO:1990845
The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.
2 O15156 (/ISS) O15156 (/ISS)
Regulation of neural precursor cell proliferation GO:2000177
Any process that modulates the frequency, rate or extent of neural precursor cell proliferation.
2 P07247 (/IMP) P07247 (/IMP)
Negative regulation of T-helper 17 cell differentiation GO:2000320
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.
2 Q64321 (/IMP) Q64321 (/IMP)
Positive regulation of SREBP signaling pathway GO:2000640
Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway.
2 Q64321 (/IMP) Q64321 (/IMP)
Positive regulation of SREBP signaling pathway GO:2000640
Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway.
2 O15156 (/ISS) O15156 (/ISS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 O15156 (/IDA) O15156 (/IDA) P07247 (/IDA) P07247 (/IDA) Q64321 (/IDA) Q64321 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q64321 (/ISO) Q64321 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 O15156 (/IDA) O15156 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q64321 (/ISO) Q64321 (/ISO)