The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Classic Zinc Finger
".
FunFam 488: Insulinoma-associated protein 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
5 | A4IHR5 (/ISS) A6H7J1 (/ISS) A7UKY7 (/ISS) Q63ZV0 (/ISS) Q63ZV0 (/ISS) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
5 | A4IHR5 (/ISS) A6H7J1 (/ISS) A7UKY7 (/ISS) Q63ZV0 (/ISS) Q63ZV0 (/ISS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | A4IHR5 (/ISS) A6H7J1 (/ISS) A7UKY7 (/ISS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q63ZV0 (/IPI) Q63ZV0 (/IPI) |
|
Cyclin binding GO:0030332
Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q96T92 (/ISA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q9JMC2 (/ISS) |
There are 45 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | A4IHR5 (/ISS) A6H7J1 (/ISS) A7UKY7 (/ISS) Q63ZV0 (/ISS) Q63ZV0 (/ISS) |
|
Transdifferentiation GO:0060290
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
|
5 | A4IHR5 (/ISS) A6H7J1 (/ISS) A7UKY7 (/ISS) Q63ZV0 (/ISS) Q63ZV0 (/ISS) |
|
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
|
3 | A6H7J1 (/ISS) Q63ZV0 (/ISS) Q63ZV0 (/ISS) |
|
Type B pancreatic cell differentiation GO:0003309
The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
|
3 | A4IHR5 (/ISS) A6H7J1 (/ISS) A7UKY7 (/ISS) |
|
Pancreatic A cell differentiation GO:0003310
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
|
3 | A4IHR5 (/ISS) A6H7J1 (/ISS) A7UKY7 (/ISS) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
3 | A6H7J1 (/ISS) Q63ZV0 (/ISS) Q63ZV0 (/ISS) |
|
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
3 | A7UKY7 (/IMP) Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Regulation of protein complex assembly GO:0043254
Any process that modulates the frequency, rate or extent of protein complex assembly.
|
3 | A6H7J1 (/ISS) Q63ZV0 (/ISS) Q63ZV0 (/ISS) |
|
Positive regulation of cell cycle arrest GO:0071158
Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
3 | A6H7J1 (/ISS) Q63ZV0 (/ISS) Q63ZV0 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
Type B pancreatic cell differentiation GO:0003309
The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
|
2 | Q63ZV0 (/IDA) Q63ZV0 (/IDA) |
|
Pancreatic A cell differentiation GO:0003310
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
|
2 | Q63ZV0 (/IDA) Q63ZV0 (/IDA) |
|
Type B pancreatic cell development GO:0003323
The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Noradrenergic neuron development GO:0003358
The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
2 | Q63ZV0 (/TAS) Q63ZV0 (/TAS) |
|
Endocrine system development GO:0035270
Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Norepinephrine biosynthetic process GO:0042421
The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Regulation of protein complex assembly GO:0043254
Any process that modulates the frequency, rate or extent of protein complex assembly.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Transdifferentiation GO:0060290
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
Adrenal chromaffin cell differentiation GO:0061104
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Sympathetic ganglion development GO:0061549
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Positive regulation of cell cycle arrest GO:0071158
Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |
|
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
|
2 | Q63ZV0 (/IMP) Q63ZV0 (/IMP) |
|
Noradrenergic neuron development GO:0003358
The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
1 | A6H7J1 (/ISS) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q9V3B8 (/IMP) |
|
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | A6H7J1 (/ISS) |
|
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
1 | A4IHR5 (/ISS) |
|
Endodermal cell differentiation GO:0035987
The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.
|
1 | A7UKY7 (/IMP) |
|
Endodermal cell differentiation GO:0035987
The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.
|
1 | A4IHR5 (/ISS) |
|
Norepinephrine biosynthetic process GO:0042421
The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
|
1 | A6H7J1 (/ISS) |
|
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
|
1 | A6H7J1 (/ISS) |
|
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
|
1 | Q9V3B8 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9JMC2 (/ISS) |
|
Gland development GO:0048732
The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.
|
1 | A7UKY7 (/IMP) |
|
Gland development GO:0048732
The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.
|
1 | A4IHR5 (/ISS) |
|
Adrenal chromaffin cell differentiation GO:0061104
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles.
|
1 | A6H7J1 (/ISS) |
|
Sympathetic ganglion development GO:0061549
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
|
1 | A6H7J1 (/ISS) |
|
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
|
1 | A6H7J1 (/ISS) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
|
5 | A4IHR5 (/ISS) A6H7J1 (/ISS) A7UKY7 (/ISS) Q63ZV0 (/ISS) Q63ZV0 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | A4IHR5 (/ISS) A6H7J1 (/ISS) A7UKY7 (/ISS) Q9JMC2 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q63ZV0 (/IDA) Q63ZV0 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q63ZV0 (/TAS) Q63ZV0 (/TAS) |
|
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
|
2 | Q63ZV0 (/ISO) Q63ZV0 (/ISO) |