The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 404: POZ-, AT hook-, and zinc finger-containing protein...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 Q9HBE1 (/ISA) Q9HBE1 (/ISA) Q9HBE1 (/ISA) Q9HBE1 (/ISA) Q9HBE1 (/ISA) Q9HBE1 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 Q9HBE1 (/ISM) Q9HBE1 (/ISM) Q9HBE1 (/ISM) Q9HBE1 (/ISM) Q9HBE1 (/ISM) Q9HBE1 (/ISM)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 Q9HBE1 (/NAS) Q9HBE1 (/NAS) Q9HBE1 (/NAS) Q9HBE1 (/NAS) Q9HBE1 (/NAS) Q9HBE1 (/NAS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q5NBY9 (/IDA) Q9JMG9 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 Q5NBY9 (/IDA) Q9JMG9 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q5NBY9 (/IPI) Q9JMG9 (/IPI)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 M9PF84 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 Q5SXC3 (/ISO)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q9JMG9 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 M9PF84 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9JMG9 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q5SXC3 (/ISO)
Enhancer binding GO:0035326
Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
1 M9PF84 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 M9PF84 (/IMP)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
6 Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
6 Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
4 M9PF84 (/IMP) O01348 (/IMP) Q5BIH1 (/IMP) Q9VTD3 (/IMP)
Neuroblast development GO:0014019
The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron.
4 M9PF84 (/IMP) O01348 (/IMP) Q5BIH1 (/IMP) Q9VTD3 (/IMP)
Sensory organ precursor cell fate determination GO:0016360
The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed.
4 M9PF84 (/IMP) O01348 (/IMP) Q5BIH1 (/IMP) Q9VTD3 (/IMP)
Neurogenesis GO:0022008
Generation of cells within the nervous system.
4 M9PF84 (/IMP) O01348 (/IMP) Q5BIH1 (/IMP) Q9VTD3 (/IMP)
Larval feeding behavior GO:0030536
Feeding behavior in a larval (immature) organism.
4 M9PF84 (/IMP) O01348 (/IMP) Q5BIH1 (/IMP) Q9VTD3 (/IMP)
Positive regulation of compound eye retinal cell programmed cell death GO:0046672
Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.
4 M9PF84 (/IMP) O01348 (/IMP) Q5BIH1 (/IMP) Q9VTD3 (/IMP)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
4 M9PF84 (/IMP) O01348 (/IMP) Q5BIH1 (/IMP) Q9VTD3 (/IMP)
Regulation of stem cell division GO:2000035
Any process that modulates the frequency, rate or extent of stem cell division.
4 M9PF84 (/IMP) O01348 (/IMP) Q5BIH1 (/IMP) Q9VTD3 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 Q5NBY9 (/IPI) Q9JMG9 (/IPI)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 Q5NBY9 (/IMP) Q9JMG9 (/IMP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
2 Q5NBY9 (/IMP) Q9JMG9 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q5NBY9 (/IDA) Q9JMG9 (/IDA)
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
2 Q5NBY9 (/IDA) Q9JMG9 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 Q5NBY9 (/ISS) Q9JMG9 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q5NBY9 (/IDA) Q9JMG9 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 M9PF84 (/IDA)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q5SXC3 (/IMP)
Endothelial cell development GO:0001885
The progression of an endothelial cell over time, from its formation to the mature structure.
1 Q5SXC3 (/IMP)
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 Q5NBY9 (/IMP)
R7 cell differentiation GO:0045466
The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor.
1 M9PF84 (/IDA)
Positive regulation of endothelial cell differentiation GO:0045603
Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.
1 Q5SXC3 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9JMG9 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q5SXC3 (/ISO)
Regulation of neuroblast proliferation GO:1902692
Any process that modulates the frequency, rate or extent of neuroblast proliferation.
1 M9PF84 (/IGI)
Regulation of neuroblast proliferation GO:1902692
Any process that modulates the frequency, rate or extent of neuroblast proliferation.
1 M9PF84 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
18 A0A024R1F8 (/IDA) A0A024R1F8 (/IDA) A0A024R1F8 (/IDA) A0A024R1F8 (/IDA) A0A024R1F8 (/IDA) A0A024R1M5 (/IDA) A0A024R1M5 (/IDA) A0A024R1M5 (/IDA) A0A024R1M5 (/IDA) A0A024R1M5 (/IDA)
(8 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 M9PF84 (/IDA) O01348 (/IDA) Q5BIH1 (/IDA) Q5NBY9 (/IDA) Q5SXC3 (/IDA) Q9JMG9 (/IDA) Q9VTD3 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS) Q9HBE1 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 Q5NBY9 (/ISO) Q5SXC3 (/ISO) Q9JMG9 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q5NBY9 (/ISS) Q9JMG9 (/ISS)