The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 359: GLIS family zinc finger 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q8VDL9 (/IPI) Q9BZE0 (/IPI) Q9BZE0 (/IPI) Q9BZE0 (/IPI)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 Q9BZE0 (/ISA) Q9BZE0 (/ISA) Q9BZE0 (/ISA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 Q9BZE0 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
3 Q9BZE0 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 Q8VDL9 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q8VDL9 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q8VDL9 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q8VDL9 (/ISS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q8VDL9 (/IDA)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
5 Q7K0S9 (/ISS) Q98T94 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 Q7K0S9 (/ISS) Q98T94 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 Q9BZE0 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
3 A0A0R4IE83 (/IMP) A0A0R4IM25 (/IMP) T1WQU8 (/IMP)
Type B pancreatic cell development GO:0003323
The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
3 A0A0R4IU95 (/IMP) A1L1Q6 (/IMP) F1QB13 (/IMP)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
3 A0A0R4IE83 (/IMP) A0A0R4IM25 (/IMP) T1WQU8 (/IMP)
Pronephric duct morphogenesis GO:0039023
The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.
3 A0A0R4IE83 (/IGI) A0A0R4IM25 (/IGI) T1WQU8 (/IGI)
Pronephric duct morphogenesis GO:0039023
The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.
3 A0A0R4IE83 (/IMP) A0A0R4IM25 (/IMP) T1WQU8 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
3 A0A0R4IU95 (/IMP) A1L1Q6 (/IMP) F1QB13 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
3 Q9BZE0 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS)
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
3 Q9BZE0 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 Q9BZE0 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS)
Convergent extension involved in axis elongation GO:0060028
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.
3 A0A0R4IE83 (/IMP) A0A0R4IM25 (/IMP) T1WQU8 (/IMP)
Left/right pattern formation GO:0060972
The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
3 A0A0R4IE83 (/IMP) A0A0R4IM25 (/IMP) T1WQU8 (/IMP)
Pancreas regeneration GO:1990798
The regrowth of a destroyed pancreas.
3 A0A0R4IU95 (/IMP) A1L1Q6 (/IMP) F1QB13 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q7K0S9 (/IDA) Q8VDL9 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q8VDL9 (/IMP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 Q8VDL9 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q8VDL9 (/ISS)
Cellular response to nutrient GO:0031670
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 Q7K0S9 (/IDA)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 Q7K0S9 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q8VDL9 (/IDA)
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
1 Q8VDL9 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8VDL9 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8VDL9 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8VDL9 (/IDA)
Regulation of transcription from RNA polymerase II promoter involved in kidney development GO:0060994
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the kidney progresses from its initial formation to the mature state.
1 Q8VDL9 (/IMP)
Cell differentiation involved in kidney development GO:0061005
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state.
1 Q8VDL9 (/IMP)
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
1 Q8VDL9 (/IGI)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
5 Q7K0S9 (/ISS) Q98T94 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q9BZE0 (/ISS) Q9BZE0 (/ISS) Q9BZE0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8VDL9 (/IDA)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 Q8VDL9 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8VDL9 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q8VDL9 (/IDA)
Non-motile cilium GO:0097730
A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.
1 Q8VDL9 (/IDA)