The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Zinc finger protein 3 homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
145 A6NHJ4 (/ISA) A6NHJ4 (/ISA) A6NHJ4 (/ISA) A6NHJ4 (/ISA) A6NHJ4 (/ISA) B7Z6K7 (/ISA) B7Z6K7 (/ISA) P13682 (/ISA) P13682 (/ISA) P13682 (/ISA)
(135 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
50 P17027 (/IPI) P17027 (/IPI) P17027 (/IPI) P17027 (/IPI) P17027 (/IPI) P17027 (/IPI) P17027 (/IPI) P17027 (/IPI) P17027 (/IPI) P17027 (/IPI)
(40 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
26 P51523 (/NAS) P51523 (/NAS) P51523 (/NAS) P51523 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS)
(16 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
22 Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS) Q03936 (/NAS)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
19 P13682 (/NAS) P13682 (/NAS) P13682 (/NAS) P13682 (/NAS) P17027 (/NAS) P17027 (/NAS) P17027 (/NAS) P17027 (/NAS) P17027 (/NAS) P17027 (/NAS)
(9 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
17 A0A286YD11 (/ISO) G3X9I0 (/ISO) G3X9I0 (/ISO) G3X9I0 (/ISO) G3X9I0 (/ISO) O88412 (/ISO) O88412 (/ISO) O88412 (/ISO) O88412 (/ISO) Q3UHV1 (/ISO)
(7 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
16 G3X9I0 (/ISO) G3X9I0 (/ISO) G3X9I0 (/ISO) G3X9I0 (/ISO) O88412 (/ISO) O88412 (/ISO) O88412 (/ISO) O88412 (/ISO) Q3UHV1 (/ISO) Q3UHV1 (/ISO)
(6 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
8 O88412 (/ISS) O88412 (/ISS) O88412 (/ISS) O88412 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
8 O88412 (/ISS) O88412 (/ISS) O88412 (/ISS) O88412 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
6 Q5TYW1 (/IDA) Q5TYW1 (/IDA) Q5TYW1 (/IDA) Q5TYW1 (/IDA) Q5TYW1 (/IDA) Q5TYW1 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 P13682 (/TAS) P13682 (/TAS) P13682 (/TAS) P13682 (/TAS) P17097 (/TAS) P17097 (/TAS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
4 P51523 (/NAS) P51523 (/NAS) P51523 (/NAS) P51523 (/NAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 P13682 (/IDA) P13682 (/IDA) P13682 (/IDA) P13682 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
4 P13682 (/IDA) P13682 (/IDA) P13682 (/IDA) P13682 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P52736 (/TAS)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
9 A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS)
Positive regulation of kinase activity GO:0033674
Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
9 A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
9 A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
9 A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS)
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
9 A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS)
Cellular response to sodium dodecyl sulfate GO:0072707
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus.
9 A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS)
Positive regulation of cell cycle phase transition GO:1901989
Any process that activates or increases the frequency, rate or extent of cell cycle phase transition.
9 A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
8 P13682 (/ISS) P13682 (/ISS) P13682 (/ISS) P13682 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
8 P13682 (/ISS) P13682 (/ISS) P13682 (/ISS) P13682 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS)
Ribosome biogenesis GO:0042254
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
6 Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
6 Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP)
Cellular response to zinc ion GO:0071294
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
6 Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP) Q5TYW1 (/IMP)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
5 P17097 (/TAS) P17097 (/TAS) Q14586 (/TAS) Q14586 (/TAS) Q14586 (/TAS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
4 P13682 (/TAS) P13682 (/TAS) P13682 (/TAS) P13682 (/TAS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
4 O88412 (/IEP) O88412 (/IEP) O88412 (/IEP) O88412 (/IEP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
4 O88412 (/IMP) O88412 (/IMP) O88412 (/IMP) O88412 (/IMP)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
4 O88412 (/IEP) O88412 (/IEP) O88412 (/IEP) O88412 (/IEP)
Blastocyst hatching GO:0001835
The hatching of the cellular blastocyst from the zona pellucida.
2 Q8BLE1 (/IMP) Q8BLE1 (/IMP)
MRNA 3'-end processing by stem-loop binding and cleavage GO:0006398
Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine.
1 Q8BI67 (/ISO)
MRNA 3'-end processing by stem-loop binding and cleavage GO:0006398
Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine.
1 Q8BI67 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 A0A286YD11 (/ISO)
Negative regulation of transposon integration GO:0070895
Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule.
1 A0A286YD11 (/ISO)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
17 A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) A1YG88 (/ISS) O88412 (/ISS)
(7 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
16 G3X9I0 (/ISO) G3X9I0 (/ISO) G3X9I0 (/ISO) G3X9I0 (/ISO) O88412 (/ISO) O88412 (/ISO) O88412 (/ISO) O88412 (/ISO) Q3UHV1 (/ISO) Q3UHV1 (/ISO)
(6 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
16 G3X9I0 (/ISO) G3X9I0 (/ISO) G3X9I0 (/ISO) G3X9I0 (/ISO) O88412 (/ISO) O88412 (/ISO) O88412 (/ISO) O88412 (/ISO) Q3UHV1 (/ISO) Q3UHV1 (/ISO)
(6 more)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
8 P13682 (/ISS) P13682 (/ISS) P13682 (/ISS) P13682 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
8 O88412 (/ISS) O88412 (/ISS) O88412 (/ISS) O88412 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS) Q5M881 (/ISS)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
7 Q09FC8 (/IDA) Q09FC8 (/IDA) Q09FC8 (/IDA) Q09FC8 (/IDA) Q09FC8 (/IDA) Q09FC8 (/IDA) Q09FC8 (/IDA)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
7 Q09FC8 (/IDA) Q09FC8 (/IDA) Q09FC8 (/IDA) Q09FC8 (/IDA) Q09FC8 (/IDA) Q09FC8 (/IDA) Q09FC8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P13682 (/IDA) P13682 (/IDA) P13682 (/IDA) P13682 (/IDA) P16373 (/IDA) P16373 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
4 O88412 (/IDA) O88412 (/IDA) O88412 (/IDA) O88412 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 P13682 (/IDA) P13682 (/IDA) P13682 (/IDA) P13682 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8BI67 (/ISO)
Cajal body GO:0015030
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
1 Q8BI67 (/ISO)
Cajal body GO:0015030
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
1 Q8BI67 (/ISS)