The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 256: PLAG1 like zinc finger 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
12 Q6DJT9 (/ISA) Q6DJT9 (/ISA) Q6DJT9 (/ISA) Q6DJT9 (/ISA) Q6DJT9 (/ISA) Q6DJT9 (/ISA) Q6DJT9 (/ISA) Q9UPG8 (/ISA) Q9UPG8 (/ISA) Q9UPG8 (/ISA)
(2 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
12 Q6DJT9 (/NAS) Q6DJT9 (/NAS) Q6DJT9 (/NAS) Q6DJT9 (/NAS) Q6DJT9 (/NAS) Q6DJT9 (/NAS) Q6DJT9 (/NAS) Q9UPG8 (/NAS) Q9UPG8 (/NAS) Q9UPG8 (/NAS)
(2 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
12 Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q9UPG8 (/IDA) Q9UPG8 (/IDA) Q9UPG8 (/IDA)
(2 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
12 Q6DJT9 (/TAS) Q6DJT9 (/TAS) Q6DJT9 (/TAS) Q6DJT9 (/TAS) Q6DJT9 (/TAS) Q6DJT9 (/TAS) Q6DJT9 (/TAS) Q9UPG8 (/TAS) Q9UPG8 (/TAS) Q9UPG8 (/TAS)
(2 more)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
7 Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 Q3UZI7 (/ISO) Q6ZQG6 (/ISO) Q925T4 (/ISO) Q9QYE0 (/ISO) Q9QZJ1 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
5 Q9UPG8 (/IDA) Q9UPG8 (/IDA) Q9UPG8 (/IDA) Q9UPG8 (/IDA) Q9UPG8 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
4 Q3UZI7 (/ISO) Q6ZQG6 (/ISO) Q925T4 (/ISO) Q9QZJ1 (/ISO)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q9QYE0 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
11 Q3UZI7 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6ZQG6 (/IDA) Q925T4 (/IDA)
(1 more)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
4 Q3UZI7 (/IMP) Q6ZQG6 (/IMP) Q925T4 (/IMP) Q9QZJ1 (/IMP)
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
4 Q3UZI7 (/IMP) Q6ZQG6 (/IMP) Q925T4 (/IMP) Q9QZJ1 (/IMP)
Chylomicron assembly GO:0034378
The non-covalent aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron.
4 Q3UZI7 (/IMP) Q6ZQG6 (/IMP) Q925T4 (/IMP) Q9QZJ1 (/IMP)
Positive regulation of intrinsic apoptotic signaling pathway GO:2001244
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
4 Q3UZI7 (/IDA) Q6ZQG6 (/IDA) Q925T4 (/IDA) Q9QZJ1 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9QYE0 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9QYE0 (/IDA)
Gland morphogenesis GO:0022612
The process in which the anatomical structures of a gland are generated and organized.
1 Q9QYE0 (/IMP)
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
1 Q9QYE0 (/IMP)
Organ growth GO:0035265
The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.
1 Q9QYE0 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9QYE0 (/ISO)
Positive regulation of glial cell proliferation GO:0060252
Any process that activates or increases the rate or extent of glial cell proliferation.
1 Q9QYE0 (/IDA)
Prostate gland growth GO:0060736
The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state.
1 Q9QYE0 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
14 A0A024R7Z0 (/IDA) A0A024R7Z0 (/IDA) A0A024R7Z0 (/IDA) A0A024R7Z0 (/IDA) A0A024R7Z0 (/IDA) A0A024R7Z0 (/IDA) A0A024R7Z0 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA) Q6DJT9 (/IDA)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q3UZI7 (/IDA) Q6ZQG6 (/IDA) Q925T4 (/IDA) Q9QZJ1 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q9QYE0 (/ISO)