The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 184: Zinc finger protein 333

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 O75346 (/ISA) Q14592 (/ISA) Q14592 (/ISA) Q8IW36 (/ISA) Q8IYI8 (/ISA) Q8IYI8 (/ISA) Q8IYI8 (/ISA) Q8IYI8 (/ISA) Q8IYI8 (/ISA) Q8NDP4 (/ISA)
(12 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 Q14592 (/IPI) Q14592 (/IPI) Q8IW36 (/IPI) Q8IYI8 (/IPI) Q8IYI8 (/IPI) Q8IYI8 (/IPI) Q8IYI8 (/IPI) Q8IYI8 (/IPI) Q8NDP4 (/IPI) Q8NDP4 (/IPI)
(5 more)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
4 G3X9T1 (/ISO) G3X9T1 (/ISO) Q8CGF2 (/ISO) Q8CGF2 (/ISO)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 G3X9T1 (/ISO) G3X9T1 (/ISO) Q8CGF2 (/ISO) Q8CGF2 (/ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 G3X9T1 (/ISO) G3X9T1 (/ISO) Q8CGF2 (/ISO) Q8CGF2 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 O75346 (/NAS)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
9 F6R4Z5 (/ISO) F6R4Z5 (/ISO) F6R4Z5 (/ISO) Q8C0I0 (/ISO) Q8C0I0 (/ISO) Q8C0I0 (/ISO) Q8VC29 (/ISO) Q8VC29 (/ISO) Q8VC29 (/ISO)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
9 F6R4Z5 (/ISO) F6R4Z5 (/ISO) F6R4Z5 (/ISO) Q8C0I0 (/ISO) Q8C0I0 (/ISO) Q8C0I0 (/ISO) Q8VC29 (/ISO) Q8VC29 (/ISO) Q8VC29 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 G3X9T1 (/ISO) G3X9T1 (/ISO) Q8CGF2 (/ISO) Q8CGF2 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 G3X9T1 (/ISO) G3X9T1 (/ISO) Q8CGF2 (/ISO) Q8CGF2 (/ISO)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
3 Q99PJ6 (/IDA) Q99PJ6 (/IDA) Q99PJ6 (/IDA)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
3 Q8VC29 (/ISS) Q8VC29 (/ISS) Q8VC29 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
3 Q99PJ6 (/IDA) Q99PJ6 (/IDA) Q99PJ6 (/IDA)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
3 Q8VC29 (/ISS) Q8VC29 (/ISS) Q8VC29 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 O75346 (/NAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 O75346 (/NAS)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 F6R4Z5 (/ISO) F6R4Z5 (/ISO) F6R4Z5 (/ISO) Q8C0I0 (/ISO) Q8C0I0 (/ISO) Q8C0I0 (/ISO) Q8VC29 (/ISO) Q8VC29 (/ISO) Q8VC29 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 G3X9T1 (/ISO) G3X9T1 (/ISO) Q8CGF2 (/ISO) Q8CGF2 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 G3X9T1 (/ISO) G3X9T1 (/ISO) Q8CGF2 (/ISO) Q8CGF2 (/ISO)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
4 G3X9T1 (/ISO) G3X9T1 (/ISO) Q8CGF2 (/ISO) Q8CGF2 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q99PJ6 (/IDA) Q99PJ6 (/IDA) Q99PJ6 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q8VC29 (/ISS) Q8VC29 (/ISS) Q8VC29 (/ISS)