The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 181: C2H2 type zinc finger protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
3 P53968 (/IDA) P53968 (/IDA) P53968 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 P53968 (/IDA) P53968 (/IDA) P53968 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 P53968 (/HDA) P53968 (/HDA) P53968 (/HDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 Q5B154 (/IDA) Q5B154 (/IDA) Q5B154 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q5A4H5 (/IGI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q5A4H5 (/ISS)

There are 52 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
5 P53968 (/IMP) P53968 (/IMP) P53968 (/IMP) Q4WJ81 (/IMP) Q4WJ81 (/IMP)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
5 Q4WJ81 (/IMP) Q4WJ81 (/IMP) Q5B154 (/IMP) Q5B154 (/IMP) Q5B154 (/IMP)
Cell wall chitin biosynthetic process GO:0006038
The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells.
3 P53968 (/IGI) P53968 (/IGI) P53968 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter by pheromones GO:0007329
Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter.
3 P53968 (/IMP) P53968 (/IMP) P53968 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
3 B9WEF9 (/IMP) Q4WJ81 (/IMP) Q4WJ81 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P53968 (/IGI) P53968 (/IGI) P53968 (/IGI)
Ion homeostasis GO:0050801
Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
3 P53968 (/IGI) P53968 (/IGI) P53968 (/IGI)
Ion homeostasis GO:0050801
Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
3 P53968 (/IMP) P53968 (/IMP) P53968 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to calcium ion GO:0061400
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus.
3 P53968 (/IMP) P53968 (/IMP) P53968 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to increased salt GO:0061404
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
3 P53968 (/IMP) P53968 (/IMP) P53968 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH GO:0061422
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0.
3 P53968 (/IMP) P53968 (/IMP) P53968 (/IMP)
Positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter GO:0061423
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter resulting in the increased frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P53968 (/IDA) P53968 (/IDA) P53968 (/IDA)
Cellular response to blue light GO:0071483
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.
3 P53968 (/IDA) P53968 (/IDA) P53968 (/IDA)
Regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter GO:0097301
Any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P53968 (/IDA) P53968 (/IDA) P53968 (/IDA)
Regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter GO:0097301
Any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P53968 (/IGI) P53968 (/IGI) P53968 (/IGI)
Regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter GO:0097301
Any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P53968 (/IMP) P53968 (/IMP) P53968 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling GO:1900622
Calcium-mediated signaling that results in positive regulation of transcription from an RNA polymerase II promoter.
3 P53968 (/IGI) P53968 (/IGI) P53968 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling GO:1900622
Calcium-mediated signaling that results in positive regulation of transcription from an RNA polymerase II promoter.
3 P53968 (/IMP) P53968 (/IMP) P53968 (/IMP)
Positive regulation of cellular response to drug GO:2001040
Any process that activates or increases the frequency, rate or extent of cellular response to drug.
3 P53968 (/IMP) P53968 (/IMP) P53968 (/IMP)
Unidimensional cell growth GO:0009826
The process in which a cell irreversibly increases in size in one
2 Q4WJ81 (/IMP) Q4WJ81 (/IMP)
Spore germination GO:0009847
The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall).
2 Q4WJ81 (/IMP) Q4WJ81 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 B9WEF9 (/IMP) Q5A4H5 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
2 B9WEF9 (/IMP) Q5A4H5 (/IMP)
Conidium formation GO:0048315
The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus.
2 Q4WJ81 (/IMP) Q4WJ81 (/IMP)
Cellular response to acidic pH GO:0071468
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
2 Q59SN6 (/IMP) Q5A4H5 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q5A4H5 (/IGI)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q5A4H5 (/ISS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q59SN6 (/IMP)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
1 Q6FJF0 (/IMP)
Bipolar cellular bud site selection GO:0007121
The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell.
1 Q5A4H5 (/IMP)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 Q5A4H5 (/IMP)
Thigmotropism GO:0009652
The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it.
1 B9WEF9 (/IMP)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 Q59SN6 (/IMP)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 Q5A4H5 (/IGI)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 Q5A4H5 (/IMP)
Cellular cation homeostasis GO:0030003
Any process involved in the maintenance of an internal steady state of cations at the level of a cell.
1 B9WEF9 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5A4H5 (/IMP)
Hyphal growth GO:0030448
Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
1 Q5A4H5 (/IMP)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
1 B9WEF9 (/IMP)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
1 Q6FJF0 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
1 Q5A4H5 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q5A4H5 (/IMP)
Single-species biofilm formation on inanimate substrate GO:0044011
A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
1 Q59SN6 (/IMP)
Cellular response to cold GO:0070417
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 Q59SN6 (/IMP)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 Q5A4H5 (/IMP)
Cellular response to copper ion GO:0071280
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
1 Q59SN6 (/IMP)
Positive regulation of cell adhesion involved in single-species biofilm formation GO:1900189
Any process that activates or increases the frequency, rate or extent of cell adhesion involved in single-species biofilm formation.
1 Q59SN6 (/IMP)
Regulation of single-species biofilm formation on inanimate substrate GO:1900231
Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
1 Q59SN6 (/IMP)
Positive regulation of phenotypic switching GO:1900241
Any process that activates or increases the frequency, rate or extent of phenotypic switching.
1 A0A1D8PFN2 (/IMP)
Positive regulation of filamentous growth of a population of unicellular organisms GO:1900430
Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms.
1 A0A1D8PFN2 (/IMP)
Positive regulation of filamentous growth of a population of unicellular organisms in response to starvation GO:1900436
Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation.
1 Q5A4H5 (/IMP)
Positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:1900445
Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus.
1 Q5A4H5 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P53968 (/IDA) P53968 (/IDA) P53968 (/IDA) Q4WJ81 (/IDA) Q4WJ81 (/IDA) Q5A4H5 (/IDA) Q5B154 (/IDA) Q5B154 (/IDA) Q5B154 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P53968 (/IDA) P53968 (/IDA) P53968 (/IDA) Q4WJ81 (/IDA) Q4WJ81 (/IDA) Q5A4H5 (/IDA) Q5B154 (/IDA) Q5B154 (/IDA) Q5B154 (/IDA)