The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: zinc finger protein 37 homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
68 P17024 (/ISA) P17024 (/ISA) P17030 (/ISA) P51508 (/ISA) P51508 (/ISA) P51508 (/ISA) P51508 (/ISA) P51786 (/ISA) P51786 (/ISA) P51786 (/ISA)
(58 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
11 Q9NQX6 (/NAS) Q9NQX6 (/NAS) Q9NQX6 (/NAS) Q9NQX6 (/NAS) Q9NQX6 (/NAS) Q9NQX6 (/NAS) Q9UL59 (/NAS) Q9UL59 (/NAS) Q9Y6Q3 (/NAS) Q9Y6Q3 (/NAS)
(1 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
10 Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P17024 (/IPI) P17024 (/IPI) Q147U1 (/IPI) Q147U1 (/IPI) Q3KQV3 (/IPI) Q8IZ26 (/IPI) Q9C0F3 (/IPI) Q9C0F3 (/IPI)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 P17030 (/NAS) P51786 (/NAS) P51786 (/NAS) P51786 (/NAS) P51786 (/NAS) P51786 (/NAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
5 P51786 (/TAS) P51786 (/TAS) P51786 (/TAS) P51786 (/TAS) P51786 (/TAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 Q9Y6Q3 (/NAS) Q9Y6Q3 (/NAS) Q9Y6Q3 (/NAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P17141 (/TAS) P17141 (/TAS) P17141 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q3KQV3 (/IPI)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
10 Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO)
Negative regulation of transposon integration GO:0070895
Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule.
10 Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
8 Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
8 Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS) Q16587 (/TAS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 P51786 (/TAS) P51786 (/TAS) P51786 (/TAS) P51786 (/TAS) P51786 (/TAS)
Regulation of cell fate commitment GO:0010453
Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
4 Q6PCM4 (/IMP) Q6PCM4 (/IMP) Q6PCM4 (/IMP) Q6PCM4 (/IMP)
Lung alveolus development GO:0048286
The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
4 Q6PCM4 (/IMP) Q6PCM4 (/IMP) Q6PCM4 (/IMP) Q6PCM4 (/IMP)
Mammary gland morphogenesis GO:0060443
The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
4 Q6PCM4 (/IMP) Q6PCM4 (/IMP) Q6PCM4 (/IMP) Q6PCM4 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 Q9Y6Q3 (/NAS) Q9Y6Q3 (/NAS) Q9Y6Q3 (/NAS)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
3 P17141 (/TAS) P17141 (/TAS) P17141 (/TAS)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 O88553 (/IEP) O88553 (/IEP)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2 O88553 (/IEP) O88553 (/IEP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
26 A0A024RAF3 (/IDA) A0A024RAF3 (/IDA) A0A0C4DG42 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) Q16587 (/IDA)
(16 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
18 A0A024RAF3 (/IDA) A0A024RAF3 (/IDA) A0A0C4DG42 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) Q8IZ26 (/IDA)
(8 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q8C0L3 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO) Q9DC47 (/ISO)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
8 Q16587 (/IDA) Q16587 (/IDA) Q16587 (/IDA) Q16587 (/IDA) Q16587 (/IDA) Q16587 (/IDA) Q16587 (/IDA) Q16587 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8BPP0 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8BPP0 (/ISO)