The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Classic Zinc Finger
".
FunFam 12: RB-associated KRAB zinc finger protein-like
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
70 |
P17014 (/ISA)
P17014 (/ISA)
P17014 (/ISA)
P17014 (/ISA)
P17014 (/ISA)
P17014 (/ISA)
P17014 (/ISA)
P17014 (/ISA)
P17014 (/ISA)
P17014 (/ISA)
(60 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
39 |
P17014 (/NAS)
P17014 (/NAS)
P17014 (/NAS)
P17014 (/NAS)
P17014 (/NAS)
P17014 (/NAS)
P17014 (/NAS)
P17014 (/NAS)
P17014 (/NAS)
P17014 (/NAS)
(29 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | P51522 (/IPI) P51522 (/IPI) P51522 (/IPI) P51522 (/IPI) Q9Y2P7 (/IPI) Q9Y2P7 (/IPI) Q9Y2P7 (/IPI) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
6 | Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
6 | Q9NYW8 (/NAS) Q9NYW8 (/NAS) Q9NYW8 (/NAS) Q9NYW8 (/NAS) Q9NYW8 (/NAS) Q9NYW8 (/NAS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
3 | Q9Y2P7 (/TAS) Q9Y2P7 (/TAS) Q9Y2P7 (/TAS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q8K2R5 (/IDA) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q8K2R5 (/IDA) |
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
|
28 |
A2A9J5 (/IMP)
A2A9J5 (/IMP)
A2A9J5 (/IMP)
A2A9J5 (/IMP)
A2A9J5 (/IMP)
A2A9J5 (/IMP)
A2A9J5 (/IMP)
A2A9J5 (/IMP)
A2A9J5 (/IMP)
A2A9J5 (/IMP)
(18 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
17 |
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
(7 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
13 |
Q3ZCX4 (/ISS)
Q3ZCX4 (/ISS)
Q3ZCX4 (/ISS)
Q3ZCX4 (/ISS)
Q3ZCX4 (/ISS)
Q3ZCX4 (/ISS)
Q7TSI0 (/ISS)
Q7TSI0 (/ISS)
Q7TSI0 (/ISS)
Q7TSI0 (/ISS)
(3 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
7 | Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
6 | Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) |
|
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
6 | Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) |
|
Embryonic placenta morphogenesis GO:0060669
The process in which the embryonic placenta is generated and organized.
|
6 | Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) Q3ZCX4 (/ISS) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | M9PCY3 (/IMP) Q8MRK4 (/IMP) Q8MRK4 (/IMP) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
3 | M9PCY3 (/IMP) Q8MRK4 (/IMP) Q8MRK4 (/IMP) |
|
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
3 | Q9Y2P7 (/TAS) Q9Y2P7 (/TAS) Q9Y2P7 (/TAS) |
|
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
|
3 | M9PCY3 (/IGI) Q8MRK4 (/IGI) Q8MRK4 (/IGI) |
|
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
|
3 | M9PCY3 (/IMP) Q8MRK4 (/IMP) Q8MRK4 (/IMP) |
|
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
|
3 | M9PCY3 (/IGI) Q8MRK4 (/IGI) Q8MRK4 (/IGI) |
|
Regulation of chromatin silencing GO:0031935
Any process that affects the rate, extent or location of chromatin silencing.
|
3 | M9PCY3 (/IMP) Q8MRK4 (/IMP) Q8MRK4 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | M9PCY3 (/IMP) Q8MRK4 (/IMP) Q8MRK4 (/IMP) |
|
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
|
3 | M9PCY3 (/IMP) Q8MRK4 (/IMP) Q8MRK4 (/IMP) |
|
Heterochromatin organization involved in chromatin silencing GO:0070868
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing.
|
3 | M9PCY3 (/IMP) Q8MRK4 (/IMP) Q8MRK4 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q8K2R5 (/IDA) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
38 |
A0A024R4S7 (/IDA)
A0A024R4S7 (/IDA)
A0A024R4S7 (/IDA)
A0A024R4S7 (/IDA)
A0A024R4S7 (/IDA)
A0A024R4S7 (/IDA)
A0A024R4S7 (/IDA)
A0A024R4S7 (/IDA)
M9PCY3 (/IDA)
P17014 (/IDA)
(28 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
20 |
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
(10 more) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
14 |
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
P17014 (/IDA)
(4 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
13 |
Q7TSI0 (/ISO)
Q7TSI0 (/ISO)
Q7TSI0 (/ISO)
Q7TSI0 (/ISO)
Q7TSI0 (/ISO)
Q7TSI0 (/ISO)
Q7TSI0 (/ISO)
Q8BQC8 (/ISO)
Q8BQC8 (/ISO)
Q8BQC8 (/ISO)
(3 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | Q7TSI0 (/ISS) Q7TSI0 (/ISS) Q7TSI0 (/ISS) Q7TSI0 (/ISS) Q7TSI0 (/ISS) Q7TSI0 (/ISS) Q7TSI0 (/ISS) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
7 | Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) Q7TSI0 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) Q9NYW8 (/TAS) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
3 | M9PCY3 (/IDA) Q8MRK4 (/IDA) Q8MRK4 (/IDA) |