The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Zinc finger protein 34

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
61 O75123 (/ISA) O75123 (/ISA) P17020 (/ISA) P17020 (/ISA) P17020 (/ISA) P17020 (/ISA) P17020 (/ISA) P17024 (/ISA) P17097 (/ISA) P17097 (/ISA)
(51 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
26 P17020 (/IPI) P17020 (/IPI) P17020 (/IPI) P17020 (/IPI) P17020 (/IPI) P17024 (/IPI) Q8IYI8 (/IPI) Q8IZ26 (/IPI) Q8N883 (/IPI) Q8NDP4 (/IPI)
(16 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
9 P17020 (/NAS) P17020 (/NAS) P17020 (/NAS) P17020 (/NAS) P17020 (/NAS) P17097 (/NAS) P17097 (/NAS) P51786 (/NAS) Q9UJW8 (/NAS)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
4 Q9HCX3 (/IDA) Q9HCX3 (/IDA) Q9HCX3 (/IDA) Q9HCX3 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P17097 (/TAS) P17097 (/TAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q8C0L3 (/ISO) Q9DC47 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P51786 (/TAS)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inflammatory response to antigenic stimulus GO:0002437
An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.
10 P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP)
Negative regulation of type 2 immune response GO:0002829
Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
10 P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
10 A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS)
Positive regulation of kinase activity GO:0033674
Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
10 A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
10 A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS)
Negative regulation of T-helper 2 cell differentiation GO:0045629
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.
10 P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP) P15620 (/IMP)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
10 A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS)
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
10 A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS)
Cellular response to sodium dodecyl sulfate GO:0072707
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus.
10 A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS)
Positive regulation of cell cycle phase transition GO:1901989
Any process that activates or increases the frequency, rate or extent of cell cycle phase transition.
10 A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS)
Positive regulation by host of viral release from host cell GO:0044791
A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells.
6 Q8TBZ5 (/IMP) Q8TBZ5 (/IMP) Q8TBZ5 (/IMP) Q8TBZ5 (/IMP) Q8TBZ5 (/IMP) Q8TBZ5 (/IMP)
Positive regulation by host of viral process GO:0044794
A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected.
6 Q8TBZ5 (/IMP) Q8TBZ5 (/IMP) Q8TBZ5 (/IMP) Q8TBZ5 (/IMP) Q8TBZ5 (/IMP) Q8TBZ5 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
5 P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA)
Positive regulation of kinase activity GO:0033674
Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
5 P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
5 P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
5 P17020 (/IMP) P17020 (/IMP) P17020 (/IMP) P17020 (/IMP) P17020 (/IMP)
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
5 P17020 (/IMP) P17020 (/IMP) P17020 (/IMP) P17020 (/IMP) P17020 (/IMP)
Cellular response to sodium dodecyl sulfate GO:0072707
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus.
5 P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA)
Positive regulation of cell cycle phase transition GO:1901989
Any process that activates or increases the frequency, rate or extent of cell cycle phase transition.
5 P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
4 Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
4 Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP)
Negative regulation of chromatin binding GO:0035562
Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
4 Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 Q9HCX3 (/IDA) Q9HCX3 (/IDA) Q9HCX3 (/IDA) Q9HCX3 (/IDA)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
4 Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP)
Positive regulation of methylation-dependent chromatin silencing GO:0090309
Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
4 Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP)
Positive regulation of histone H3-K9 trimethylation GO:1900114
Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation.
4 Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP)
Positive regulation of histone H3-K27 trimethylation GO:1902466
Any process that activates or increases the frequency, rate or extent of histone H3-K27 trimethylation.
4 Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP)
Negative regulation of anoikis GO:2000811
Any process that stops, prevents or reduces the frequency, rate or extent of anoikis.
4 Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP) Q9HCX3 (/IMP)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
2 P17097 (/TAS) P17097 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 Q8C0L3 (/ISO) Q9DC47 (/ISO)
Negative regulation of transposon integration GO:0070895
Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule.
2 Q8C0L3 (/ISO) Q9DC47 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P51786 (/TAS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
12 P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) Q8NA42 (/IDA) Q8TBZ5 (/IDA) Q8TBZ5 (/IDA) Q8TBZ5 (/IDA) Q8TBZ5 (/IDA)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A1YF12 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS) A2T759 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
10 A0A0C4DG42 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) Q8IZ26 (/IDA) Q8WV37 (/IDA) Q8WV37 (/IDA) Q8WV37 (/IDA) Q8WV37 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 A0A0C4DG42 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) F8WEZ9 (/IDA) Q8IZ26 (/IDA) Q8WV37 (/IDA) Q8WV37 (/IDA) Q8WV37 (/IDA) Q8WV37 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
5 P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA) P17020 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 A0A087WRR7 (/ISO) Q8C0L3 (/ISO) Q9DC47 (/ISO)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 Q8NA42 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 A0A087WRR7 (/ISO)