The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Porphobilinogen deaminase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2: Porphobilinogen deaminase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hydroxymethylbilane synthase activity GO:0004418
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
23 O94048 (/IMP) O94048 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP)
(13 more)
Hydroxymethylbilane synthase activity GO:0004418
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
14 P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA)
(4 more)
Hydroxymethylbilane synthase activity GO:0004418
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
2 Q09899 (/ISS) Q54P93 (/ISS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
23 O94048 (/IMP) O94048 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP)
(13 more)
Protoporphyrinogen IX biosynthetic process GO:0006782
The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.
14 P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA)
(4 more)
Peptidyl-pyrromethane cofactor linkage GO:0018160
The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine.
14 P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA)
(4 more)
Tetrapyrrole biosynthetic process GO:0033014
The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
14 P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP)
(4 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
2 O94048 (/IMP) O94048 (/IMP)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
1 Q54P93 (/ISS)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
14 P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA)
(4 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA)
(4 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) Q09899 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q09899 (/ISS)