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CATH Superfamily 3.30.1540.10

formyl-coa transferase, domain 3

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
formyl-coa transferase, domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 12 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
L-carnitine CoA-transferase. [EC: 2.8.3.21]
(1) (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4- (trimethylammonio)but-2-enoate + L-carnitinyl-CoA. (2) 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA.
  • The enzyme is found in gammaproteobacteria such as Proteus sp. and Escherichia coli.
  • It has similar activity with both substrates.
  • Formerly EC 4.2.1.89.
 217 A0A023YSC7 A0A024L7M1 A0A025CMS4 A0A026V7D5 A0A028AHF0 A0A028DNN0 A0A029IEW1 A0A029J3A2 A0A066Q1J9 A0A070FK40
(207 more...)
Formyl-CoA transferase. [EC: 2.8.3.16]
Formyl-CoA + oxalate = formate + oxalyl-CoA.
  • The enzyme from Oxalobacter formigenes can also catalyze the transfer of CoA from formyl-CoA to succinate.
 147 A0A026UK07 A0A028AT38 A0A070FGR8 A0A090NLK2 A0A0A0FDL6 A0A0A6ZWK8 A0A0A8UGC8 A0A0E0V7G4 A0A0E0XXW4 A0A0E1M495
(137 more...)
CoA:oxalate CoA-transferase. [EC: 2.8.3.19]
Acetyl-CoA + oxalate = acetate + oxalyl-CoA.
  • The enzymes characterized from the bacteria Escherichia coli and Acetobacter aceti can also use formyl-CoA and oxalate (EC 2.8.3.16) or formyl-CoA and acetate, with significantly reduced specific activities.
 63 A0A026UKS6 A0A028AU26 A0A028EEB2 A0A069XZ12 A0A070FEL1 A0A070SPD8 A0A070UZF0 A0A073FUW3 A0A074HXM3 A0A080FTV0
(53 more...)
Succinyl-CoA:(R)-benzylsuccinate CoA-transferase. [EC: 2.8.3.15]
Succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl- CoA.
  • Involved in anaerobic catabolism of toluene and is a strictly toluene-induced enzyme that catalyzes the reversible regio- and enantio-selective synthesis of (R)-2-benzylsuccinyl-CoA.
  • The enzyme from Thauera aromatica is inactive when (R)- benzylsuccinate is replaced by (S)-benzylsuccinate.
 5 A0A1H5T8P5 A0A1H5TAH7 A0A2R4BRK8 Q9KJE9 Q9KJF0
Succinyl-CoA--L-malate CoA-transferase. [EC: 2.8.3.22]
(1) Succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA. (2) Succinyl-CoA + (S)-citramalate = succinate + (S)-citramalyl-CoA.
  • The enzyme, purified from the bacterium Chloroflexus aurantiacus, can also accept itaconate as acceptor, with lower efficiency.
  • It is part of the 3-hydroxypropanoate cycle for carbon assimilation.
 4 A9WC39 A9WC40 Q1KLK0 Q1KLK1
Succinate--hydroxymethylglutarate CoA-transferase. [EC: 2.8.3.13]
Succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + (S)-3-hydroxy-3- methylglutaryl-CoA.
  • Malonyl-CoA can also act as donor, more slowly.
 3 Q68FU4 Q7TNE1 Q9HAC7
Alpha-methylacyl-CoA racemase. [EC: 5.1.99.4]
(2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.
  • Alpha-methyl-branched acyl-CoA derivatives with chain lengths of more than C(10) are substrates.
  • Also active toward some aromatic compounds (e.g. ibuprofen) and bile acid intermediates, such as trihydroxycoprostanoyl-CoA.
  • Not active toward free acids.
 3 O09174 P70473 Q9UHK6
2-methylfumaryl-CoA isomerase. [EC: 5.4.1.3]
2-methylfumaryl-CoA = 3-methylfumaryl-CoA.
  • The enzyme, purified from the bacterium Chloroflexus aurantiacus, acts as an intramolecular CoA transferase and does not transfer CoA to free mesaconate.
  • It is part of the 3-hydroxypropanoate cycle for carbon assimilation.
 1 A9WC36
Succinyl-CoA--D-citramalate CoA-transferase. [EC: 2.8.3.20]
(1) Succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA. (2) Succinyl-CoA + (R)-malate = succinate + (R)-malyl-CoA.
  • The enzyme, purified from the bacterium Clostridium tetanomorphum, can also accept itaconate as acceptor, with lower efficiency.
 1 A9WGE3
Isopenicillin-N epimerase. [EC: 5.1.1.17]
Isopenicillin N = penicillin N.
  • Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, to produce cephalosporins.
  • Forms part of the penicillin biosynthesis pathway.
 1 Q8J0F0
Bile acid CoA-transferase. [EC: 2.8.3.25]
(1) Lithocholoyl-CoA + cholate = lithocholate + choloyl-CoA. (2) Deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA.
  • The enzyme, characterized from the gut bacterium Clostridium scindens, catalyzes the last step in bile acid 7-alpha- dehydroxylation, the removal of the CoA moiety from the products.
  • By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules.
  • The enzyme has a broad substrate specificity and can use multiple acceptors, including allocholate, ursodeoxycholate, and beta- muricholate.
  • Formerly EC 3.1.2.26.
 1 P19413
3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase. [EC: 2.8.3.17]
(1) (E)-cinnamoyl-CoA + (R)-phenyllactate = (E)-cinnamate + (R)- phenyllactyl-CoA. (2) (E)-4-coumaroyl-CoA + (R)-3-(4-hydroxyphenyl)lactate = 4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA. (3) 3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = 3-(indol-3- yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA.
  • The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan.
  • It forms a complex with (R)-3-(aryl)lactoyl-CoA dehydratase.
 1 Q93AM1