The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

MutL, C-terminal domain, regulatory subdomain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: MutL, C-terminal domain, regulatory subdomain

The protein MutL is essential in mismatch repair as it coordinating multiple protein-protein interactions that signal strand removal upon mismatch recognition by MutS. MutL is composed of two structurally conserved domains connected by a variable flexible linker: an N-terminal ATPase domain and C-terminal dimerisation domain PMID:15470502. The latter harbours the the endonuclease activity of the protein. Structural studies have shown that this C-terminal region is organized into a dimerization and a regulatory subdomain connected by a helical lever spanning the conserved endonuclease motif. Structural domains comprising this superfamily share the structure of the regulatory subdomain of the C-terminal domain of the MutL protein PMID:20603082.

GO Diversity

Unique GO annotations
52 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
10689 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 12
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 3
Unique PDBs: 5
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 42
Unique EC:
Unique GO: 52
Unique Species: 10689