The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glucose permease domain IIB
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: PTS system glucose-specific IIBC component PtsG

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
160 P19642 (/IPI) P19642 (/IPI) P19642 (/IPI) P19642 (/IPI) P19642 (/IPI) P19642 (/IPI) P19642 (/IPI) P19642 (/IPI) P19642 (/IPI) P19642 (/IPI)
(150 more)
Protein-phosphocysteine-glucose phosphotransferase system transporter activity GO:0090564
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
150 P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP)
(140 more)
N-acetylglucosamine transmembrane transporter activity GO:0015572
Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.
26 Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS)
(16 more)
Protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity GO:0090588
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in).
25 P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP)
(15 more)
Protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity GO:0090588
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in).
25 P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM)
(15 more)
Glucose transmembrane transporter activity GO:0005355
Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
10 Q81MH9 (/ISS) Q81MH9 (/ISS) Q81MH9 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS)
Sucrose transmembrane transporter activity GO:0008515
Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane.
10 A0A0F7RH17 (/ISS) A0A0F7RH17 (/ISS) Q81UP0 (/ISS) Q81UP0 (/ISS) Q81UP0 (/ISS) Q9KLT8 (/ISS) Q9KVD9 (/ISS) Q9KVD9 (/ISS) Q9KVD9 (/ISS) Q9KVD9 (/ISS)
Trehalose transmembrane transporter activity GO:0015574
Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens.
7 A0A0F7RHA4 (/ISS) A0A0F7RHA4 (/ISS) Q9KTJ2 (/ISS) Q9KTJ2 (/ISS) Q9KTJ2 (/ISS) Q9KTJ2 (/ISS) Q9KTJ2 (/ISS)
Protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity GO:0090586
: Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in).
2 P09323 (/IDA) P09323 (/IDA)
Protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity GO:0090586
: Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in).
2 P09323 (/NAS) P09323 (/NAS)
Protein-phosphocysteine-trehalose phosphotransferase system transporter activity GO:0090589
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in).
2 P36672 (/IDA) P36672 (/IDA)
Protein-phosphocysteine-trehalose phosphotransferase system transporter activity GO:0090589
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in).
2 P36672 (/IMP) P36672 (/IMP)
Protein-phosphocysteine-trehalose phosphotransferase system transporter activity GO:0090589
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in).
2 P36672 (/ISM) P36672 (/ISM)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0009401
The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
154 P09323 (/IDA) P09323 (/IDA) P36672 (/IDA) P36672 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA)
(144 more)
Glucose transmembrane transport GO:1904659
The process in which glucose is transported across a membrane.
150 P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP) P69786 (/IMP)
(140 more)
Phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0009401
The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
53 A0A0F7RH17 (/ISS) A0A0F7RH17 (/ISS) A0A0F7RHA4 (/ISS) A0A0F7RHA4 (/ISS) Q81MH9 (/ISS) Q81MH9 (/ISS) Q81MH9 (/ISS) Q81UP0 (/ISS) Q81UP0 (/ISS) Q81UP0 (/ISS)
(43 more)
Phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0009401
The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
27 P36672 (/IMP) P36672 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP)
(17 more)
N-acetylglucosamine transport GO:0015764
The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
26 Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS) Q81YX8 (/ISS)
(16 more)
Phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0009401
The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
25 P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM)
(15 more)
Carbohydrate transmembrane transport GO:0034219
The process in which a carbohydrate is transported across a membrane.
25 P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP) P77272 (/IMP)
(15 more)
Sucrose transport GO:0015770
The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside.
13 A0A0F7RH17 (/ISS) A0A0F7RH17 (/ISS) Q81MH9 (/ISS) Q81MH9 (/ISS) Q81MH9 (/ISS) Q81UP0 (/ISS) Q81UP0 (/ISS) Q81UP0 (/ISS) Q9KLT8 (/ISS) Q9KVD9 (/ISS)
(3 more)
Carbohydrate utilization GO:0009758
A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism.
10 P19642 (/IGI) P19642 (/IGI) P19642 (/IGI) P19642 (/IGI) P19642 (/IGI) P19642 (/IGI) P19642 (/IGI) P19642 (/IGI) P19642 (/IGI) P19642 (/IGI)
Glucose transmembrane transport GO:1904659
The process in which glucose is transported across a membrane.
10 Q81MH9 (/ISS) Q81MH9 (/ISS) Q81MH9 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS) Q9KQI5 (/ISS)
Trehalose transport GO:0015771
The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.
7 A0A0F7RHA4 (/ISS) A0A0F7RHA4 (/ISS) Q9KTJ2 (/ISS) Q9KTJ2 (/ISS) Q9KTJ2 (/ISS) Q9KTJ2 (/ISS) Q9KTJ2 (/ISS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
2 P09323 (/IEP) P09323 (/IEP)
N-acetylglucosamine transport GO:0015764
The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P09323 (/IDA) P09323 (/IDA)
N-acetylglucosamine transport GO:0015764
The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9HXN4 (/IMP) Q9HXN4 (/IMP)
Trehalose transport GO:0015771
The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.
2 P36672 (/IDA) P36672 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
222 P08722 (/IDA) P08722 (/IDA) P08722 (/IDA) P08722 (/IDA) P08722 (/IDA) P08722 (/IDA) P08722 (/IDA) P08722 (/IDA) P08722 (/IDA) P08722 (/IDA)
(212 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
150 P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA)
(140 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
150 P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA) P69786 (/IDA)
(140 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
25 P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM) P77272 (/ISM)
(15 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
25 P77272 (/IDA) P77272 (/IDA) P77272 (/IDA) P77272 (/IDA) P77272 (/IDA) P77272 (/IDA) P77272 (/IDA) P77272 (/IDA) P77272 (/IDA) P77272 (/IDA)
(15 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
14 P09323 (/RCA) P09323 (/RCA) P19642 (/RCA) P19642 (/RCA) P19642 (/RCA) P19642 (/RCA) P19642 (/RCA) P19642 (/RCA) P19642 (/RCA) P19642 (/RCA)
(4 more)