The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PurM-like, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Phosphoribosylformylglycinamidine cyclo-ligase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphoribosylformylglycinamidine cyclo-ligase activity GO:0004641
Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.
44 P07244 (/ISS) P07244 (/ISS) P07244 (/ISS) P07244 (/ISS) P07244 (/ISS) P07244 (/ISS) Q48FI4 (/ISS) Q48FI4 (/ISS) Q48FI4 (/ISS) Q48FI4 (/ISS)
(34 more)
Phosphoribosylformylglycinamidine cyclo-ligase activity GO:0004641
Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.
16 G3V918 (/IDA) P00967 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA)
(6 more)
Phosphoribosylamine-glycine ligase activity GO:0004637
Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.
6 P07244 (/ISS) P07244 (/ISS) P07244 (/ISS) P07244 (/ISS) P07244 (/ISS) P07244 (/ISS)
Phosphoribosylamine-glycine ligase activity GO:0004637
Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.
3 G3V918 (/IDA) P00967 (/IDA) P20772 (/IDA)
Phosphoribosylamine-glycine ligase activity GO:0004637
Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.
2 P00967 (/IMP) P20772 (/IMP)
Phosphoribosylamine-glycine ligase activity GO:0004637
Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.
2 P21872 (/TAS) P22102 (/TAS)
Phosphoribosylformylglycinamidine cyclo-ligase activity GO:0004641
Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.
2 P00967 (/IMP) P20772 (/IMP)
Phosphoribosylformylglycinamidine cyclo-ligase activity GO:0004641
Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.
2 P21872 (/TAS) P22102 (/TAS)
Phosphoribosylglycinamide formyltransferase activity GO:0004644
Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.
2 G3V918 (/IDA) P00967 (/IDA)
Phosphoribosylglycinamide formyltransferase activity GO:0004644
Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.
2 P21872 (/TAS) P22102 (/TAS)
Phosphoribosylamine-glycine ligase activity GO:0004637
Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.
1 Q64737 (/ISO)
Phosphoribosylamine-glycine ligase activity GO:0004637
Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.
1 C8V0S2 (/RCA)
Phosphoribosylformylglycinamidine cyclo-ligase activity GO:0004641
Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.
1 Q64737 (/ISO)
Phosphoribosylformylglycinamidine cyclo-ligase activity GO:0004641
Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.
1 C8V0S2 (/RCA)
Phosphoribosylglycinamide formyltransferase activity GO:0004644
Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.
1 P00967 (/IMP)
Phosphoribosylglycinamide formyltransferase activity GO:0004644
Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.
1 Q64737 (/ISO)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 Q05728 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q97TA2 (/IPI)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q05728 (/IDA)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Purine ribonucleotide biosynthetic process GO:0009152
The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
38 Q48FI4 (/ISS) Q48FI4 (/ISS) Q48FI4 (/ISS) Q48FI4 (/ISS) Q48FI4 (/ISS) Q48FI4 (/ISS) Q48FI4 (/ISS) Q48FI4 (/ISS) Q885Y1 (/ISS) Q885Y1 (/ISS)
(28 more)
Purine nucleobase metabolic process GO:0006144
The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
6 P07244 (/TAS) P07244 (/TAS) P07244 (/TAS) P07244 (/TAS) P07244 (/TAS) P07244 (/TAS)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
4 A0A0G2KGL2 (/IMP) A0A0G2KKC3 (/IMP) Q7ZUW1 (/IMP) Q9I9E6 (/IMP)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
4 A0A0G2KGL2 (/IMP) A0A0G2KKC3 (/IMP) Q7ZUW1 (/IMP) Q9I9E6 (/IMP)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
4 A0A0G2KGL2 (/IMP) A0A0G2KKC3 (/IMP) Q7ZUW1 (/IMP) Q9I9E6 (/IMP)
Brainstem development GO:0003360
The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.
1 G3V918 (/IEP)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
1 C8V0S2 (/RCA)
'de novo' IMP biosynthetic process GO:0006189
The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
1 P20772 (/IMP)
'de novo' IMP biosynthetic process GO:0006189
The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
1 P21872 (/TAS)
Glycine metabolic process GO:0006544
The chemical reactions and pathways involving glycine, aminoethanoic acid.
1 G3V918 (/IDA)
Glycine metabolic process GO:0006544
The chemical reactions and pathways involving glycine, aminoethanoic acid.
1 Q64737 (/ISO)
Cellular metal ion homeostasis GO:0006875
Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell.
1 A0A1D8PE67 (/IMP)
Purine nucleobase biosynthetic process GO:0009113
The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
1 P00967 (/IC)
Purine nucleobase biosynthetic process GO:0009113
The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
1 P20772 (/IDA)
Purine nucleobase biosynthetic process GO:0009113
The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
1 P00967 (/IMP)
Ribonucleoside monophosphate biosynthetic process GO:0009156
The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.
1 G3V918 (/IDA)
Ribonucleoside monophosphate biosynthetic process GO:0009156
The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.
1 Q64737 (/ISO)
Purine ribonucleoside monophosphate biosynthetic process GO:0009168
The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
1 P22102 (/TAS)
Cobalamin metabolic process GO:0009235
The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
1 G3V918 (/TAS)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 A0A1D8PE67 (/IMP)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 G3V918 (/IDA)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 Q64737 (/ISO)
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
1 G3V918 (/IDA)
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
1 Q64737 (/ISO)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 G3V918 (/IEP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
1 G3V918 (/IEP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 A0A1D8PE67 (/IMP)
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
1 A0A1D8PE67 (/IMP)
Adenine biosynthetic process GO:0046084
The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.
1 A0A1D8PE67 (/IMP)
Tetrahydrofolate biosynthetic process GO:0046654
The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
1 G3V918 (/IDA)
Tetrahydrofolate biosynthetic process GO:0046654
The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
1 Q64737 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA) P08178 (/IDA)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 O53823 (/HDA) O53823 (/HDA) O53823 (/HDA) O53823 (/HDA) O53823 (/HDA) O53823 (/HDA) O53823 (/HDA) O53823 (/HDA) O53823 (/HDA) O53823 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P07244 (/HDA) P07244 (/HDA) P07244 (/HDA) P07244 (/HDA) P07244 (/HDA) P07244 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P00967 (/HDA) P20772 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P21872 (/TAS) P22102 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q05728 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q05728 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 Q05728 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P22102 (/HDA)