The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Chromosome 19 SCAF14664, whole genome shotgun sequ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
IMP dehydrogenase activity GO:0003938
Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
15 P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P20839 (/TAS) P38697 (/TAS) P38697 (/TAS) P38697 (/TAS) P50095 (/TAS)
(5 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 P12268 (/IPI) P12268 (/IPI) P12268 (/IPI) P12268 (/IPI) P12268 (/IPI) P50094 (/IPI) P50095 (/IPI) P50095 (/IPI) P50095 (/IPI) P50095 (/IPI)
(2 more)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
10 P38697 (/HDA) P38697 (/HDA) P38697 (/HDA) P50094 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
5 P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA)
IMP dehydrogenase activity GO:0003938
Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
5 E9PU28 (/IDA) O14344 (/IDA) P24547 (/IDA) P24547 (/IDA) P50096 (/IDA)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
4 P12269 (/ISS) P24547 (/ISS) P24547 (/ISS) Q3SWY3 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
3 P38697 (/IDA) P38697 (/IDA) P38697 (/IDA)
IMP dehydrogenase activity GO:0003938
Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
3 P50094 (/ISS) Q07152 (/ISS) Q07152 (/ISS)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
2 P24547 (/ISO) P24547 (/ISO)
IMP dehydrogenase activity GO:0003938
Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
2 Q59Q46 (/IMP) Q59Q46 (/IMP)
IMP dehydrogenase activity GO:0003938
Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
2 P24547 (/ISO) P24547 (/ISO)
Nucleic acid binding GO:0003676
Interacting selectively and non-covalently with any nucleic acid.
1 P20839 (/IDA)
Nucleic acid binding GO:0003676
Interacting selectively and non-covalently with any nucleic acid.
1 P50096 (/ISO)
Nucleic acid binding GO:0003676
Interacting selectively and non-covalently with any nucleic acid.
1 P50096 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P20839 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P50096 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P50096 (/ISS)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTP biosynthetic process GO:0006183
The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate.
9 P38697 (/TAS) P38697 (/TAS) P38697 (/TAS) P50095 (/TAS) P50095 (/TAS) P50095 (/TAS) P50095 (/TAS) P50095 (/TAS) P50095 (/TAS)
Purine ribonucleoside monophosphate biosynthetic process GO:0009168
The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
6 P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P20839 (/TAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
6 P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P20839 (/TAS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
5 P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
5 E9PU28 (/ISS) P12269 (/ISS) P24547 (/ISS) P24547 (/ISS) Q3SWY3 (/ISS)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
3 P24547 (/IMP) P24547 (/IMP) P50096 (/IMP)
Lymphocyte proliferation GO:0046651
The expansion of a lymphocyte population by cell division.
3 P24547 (/IMP) P24547 (/IMP) P50096 (/IMP)
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
2 Q6GMG5 (/IMP) Q6GMG5 (/IMP)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
2 P24547 (/ISO) P24547 (/ISO)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
2 Q07152 (/ISS) Q07152 (/ISS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 Q07152 (/IMP) Q07152 (/IMP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
2 P24547 (/ISO) P24547 (/ISO)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
2 Q59Q46 (/IMP) Q59Q46 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
2 Q59Q46 (/IMP) Q59Q46 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 Q59Q46 (/IMP) Q59Q46 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
2 Q59Q46 (/IMP) Q59Q46 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
2 Q59Q46 (/IMP) Q59Q46 (/IMP)
Induction by symbiont of host defense response GO:0044416
The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2 Q59Q46 (/IDA) Q59Q46 (/IDA)
Developmental pigmentation GO:0048066
The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
2 Q6GMG5 (/IMP) Q6GMG5 (/IMP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
2 P24547 (/ISO) P24547 (/ISO)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
2 D3ZLZ7 (/IEP) E9PU28 (/IEP)
Cellular response to interleukin-4 GO:0071353
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.
2 P24547 (/IDA) P24547 (/IDA)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 E9PU28 (/IDA)
GTP biosynthetic process GO:0006183
The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate.
1 O14344 (/EXP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 B0UXP9 (/IMP)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 D3ZLZ7 (/IEP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 E9PU28 (/IDA)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
16 P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P20839 (/IDA) P38697 (/IDA) P38697 (/IDA) P38697 (/IDA) P50094 (/IDA)
(6 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 P38697 (/HDA) P38697 (/HDA) P38697 (/HDA) P50094 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 C9J381 (/IDA) H0Y4R1 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P20839 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
6 P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P20839 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P12268 (/IDA) P20839 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P20839 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P50095 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA) P50095 (/HDA)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
6 P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P20839 (/TAS)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
6 P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P12268 (/TAS) P20839 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P12269 (/ISS) P24547 (/ISS) P24547 (/ISS) P50096 (/ISS) Q3SWY3 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P12269 (/ISS) P24547 (/ISS) P24547 (/ISS) P50096 (/ISS) Q3SWY3 (/ISS)
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
5 P12268 (/HDA) P12268 (/HDA) P12268 (/HDA) P12268 (/HDA) P12268 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 P12268 (/HDA) P12268 (/HDA) P12268 (/HDA) P12268 (/HDA) P12268 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 P12268 (/HDA) P12268 (/HDA) P12268 (/HDA) P12268 (/HDA) P12268 (/HDA)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
3 P38697 (/IDA) P38697 (/IDA) P38697 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P24547 (/ISO) P24547 (/ISO) P50096 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P24547 (/ISO) P24547 (/ISO) P50096 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P24547 (/ISO) P24547 (/ISO) P50096 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O14344 (/HDA)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
1 P20839 (/TAS)