The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 31: Glutamate synthase 1 [NADH]

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamate synthase activity GO:0015930
Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors.
6 Q606H7 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P55037 (/IPI) P96218 (/IPI) P96218 (/IPI) P96218 (/IPI) P96218 (/IPI)
Glutamate synthase (NADH) activity GO:0016040
Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH.
5 Q12680 (/IDA) Q12680 (/IDA) Q12680 (/IDA) Q9C102 (/IDA) Q9LV03 (/IDA)
Glutamate synthase (NADH) activity GO:0016040
Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH.
5 C8VEZ6 (/IMP) Q12680 (/IMP) Q12680 (/IMP) Q12680 (/IMP) Q9LV03 (/IMP)
Glutamate synthase (NADH) activity GO:0016040
Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH.
1 C8VEZ6 (/ISA)
Glutamate synthase (NADH) activity GO:0016040
Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH.
1 C8VEZ6 (/RCA)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
6 Q606H7 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
3 Q12680 (/IEP) Q12680 (/IEP) Q12680 (/IEP)
Ammonia assimilation cycle GO:0019676
The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
3 Q12680 (/IEP) Q12680 (/IEP) Q12680 (/IEP)
Ammonia assimilation cycle GO:0019676
The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
3 Q0JKD0 (/IMP) Q9C102 (/IMP) Q9LV03 (/IMP)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
2 Q0JKD0 (/IMP) Q9LV03 (/IMP)
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
2 Q0JKD0 (/IMP) Q9LV03 (/IMP)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
1 Q9LV03 (/IDA)
Glutamine family amino acid metabolic process GO:0009064
The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
1 C8VEZ6 (/IGI)
Glutamine family amino acid metabolic process GO:0009064
The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
1 C8VEZ6 (/IMP)
Glutamine family amino acid metabolic process GO:0009064
The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
1 C8VEZ6 (/RCA)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
1 Q9LV03 (/IDA)
Ammonia assimilation cycle GO:0019676
The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
1 Q9C102 (/EXP)
Invasive filamentous growth GO:0036267
The growth of colonies in filamentous chains of cells into a substrate.
1 Q9C102 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q9LV03 (/IEP)
Response to ammonium ion GO:0060359
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus.
1 Q0JKD0 (/IEP)
L-glutamate biosynthetic process GO:0097054
The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid.
1 Q9C102 (/EXP)
L-glutamate biosynthetic process GO:0097054
The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid.
1 Q9C102 (/IDA)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P96218 (/HDA) P96218 (/HDA) P96218 (/HDA) P96218 (/HDA) Q9C102 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P96218 (/HDA) P96218 (/HDA) P96218 (/HDA) P96218 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q12680 (/HDA) Q12680 (/HDA) Q12680 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9C102 (/ISO)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q9LV03 (/IDA)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
1 Q0JKD0 (/IDA)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
1 Q9LV03 (/TAS)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 Q9LV03 (/IDA)