The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphoenolpyruvate-binding domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Isocitrate lyase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Isocitrate lyase activity GO:0004451
Catalysis of the reaction: isocitrate = glyoxylate + succinate.
110 P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA)
(100 more)
Cation binding GO:0043169
Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge.
97 P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA) P0A9G6 (/IDA)
(87 more)
Zymogen binding GO:0035375
Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.
13 P9WKK7 (/IPI) P9WKK7 (/IPI) P9WKK7 (/IPI) P9WKK7 (/IPI) P9WKK7 (/IPI) P9WKK7 (/IPI) P9WKK7 (/IPI) P9WKK7 (/IPI) P9WKK7 (/IPI) P9WKK7 (/IPI)
(3 more)
Methylisocitrate lyase activity GO:0046421
Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
13 P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA)
(3 more)
Isocitrate lyase activity GO:0004451
Catalysis of the reaction: isocitrate = glyoxylate + succinate.
12 Q10663 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS)
(2 more)
Malate synthase activity GO:0004474
Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+).
1 Q10663 (/ISS)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
97 P0A9G6 (/IC) P0A9G6 (/IC) P0A9G6 (/IC) P0A9G6 (/IC) P0A9G6 (/IC) P0A9G6 (/IC) P0A9G6 (/IC) P0A9G6 (/IC) P0A9G6 (/IC) P0A9G6 (/IC)
(87 more)
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
13 P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA)
(3 more)
Isocitrate metabolic process GO:0006102
The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle.
13 P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA)
(3 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
13 P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA)
(3 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
13 P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP)
(3 more)
Response to acetate GO:0010034
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus.
13 P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA)
(3 more)
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
13 P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP)
(3 more)
Response to host immune response GO:0052572
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
13 P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP)
(3 more)
Response to fatty acid GO:0070542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
13 P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA)
(3 more)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
13 P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP) P9WKK7 (/IEP)
(3 more)
Maintenance of symbiont tolerance to host environment GO:0075141
Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against the components of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
13 P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP) P9WKK7 (/IMP)
(3 more)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
11 Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS) Q9KTZ4 (/ISS)
(1 more)
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
1 Q10663 (/ISS)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q10663 (/IGI)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
110 P0A9G6 (/HDA) P0A9G6 (/HDA) P0A9G6 (/HDA) P0A9G6 (/HDA) P0A9G6 (/HDA) P0A9G6 (/HDA) P0A9G6 (/HDA) P0A9G6 (/HDA) P0A9G6 (/HDA) P0A9G6 (/HDA)
(100 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
13 P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA) P9WKK7 (/IDA)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
13 P9WKK7 (/HDA) P9WKK7 (/HDA) P9WKK7 (/HDA) P9WKK7 (/HDA) P9WKK7 (/HDA) P9WKK7 (/HDA) P9WKK7 (/HDA) P9WKK7 (/HDA) P9WKK7 (/HDA) P9WKK7 (/HDA)
(3 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q10663 (/HDA)