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CATH Superfamily 3.20.20.60

Phosphoenolpyruvate-binding domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphoenolpyruvate-binding domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: 5-keto-4-deoxy-D-glucarate aldolase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-dehydro-3-deoxyglucarate aldolase. [EC: 4.1.2.20]
2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde.
    		 15536 A0A026UQ57 A0A026UQ57 A0A026UQ57 A0A026UQ57 A0A026UQ57 A0A026UQ57 A0A026UQ57 A0A026UQ57 A0A026UQ57 A0A026UQ57
    (15526 more...)
    2-keto-3-deoxy-L-rhamnonate aldolase. [EC: 4.1.2.53]
    2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde.
    • The enzyme can also use 2-oxo-3-deoxy-L-mannonate, 2-oxo-3-deoxy-L- lyxonate and 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) as substrates.
    • Formerly EC 4.1.2.n3.
    		 3624 A0A024L0Q5 A0A024L0Q5 A0A024L0Q5 A0A024L0Q5 A0A024L0Q5 A0A024L0Q5 A0A024L0Q5 A0A024L0Q5 A0A024L0Q5 A0A024L0Q5
    (3614 more...)
    4-hydroxy-2-oxoheptanedioate aldolase. [EC: 4.1.2.52]
    4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde.
    • The enzyme is also able to catalyze the aldol cleavage of 4-hydroxy- 2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use 2-oxobutanoate as carbonyl donor, with lower efficiency.
    • In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate.
    • The enzyme from the bacterium Escherichia coli produces a racemic mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate.
    • Formerly EC 4.1.2.n4.
    		 797 A0A0D6GLA9 A0A0D6GLA9 A0A0D6GLA9 A0A0D6GLA9 A0A0D6GLA9 A0A0D6GLA9 A0A0D6GLA9 A0A0D6GLA9 A0A0D6GLA9 A0A0D6GLA9
    (787 more...)