The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EAL domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Cyclic di-GMP phosphodiesterase yahA

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cyclic-guanylate-specific phosphodiesterase activity GO:0071111
Catalysis of the reaction: cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine + H(+).
52 P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA)
(42 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
28 P76129 (/IPI) P76129 (/IPI) P76129 (/IPI) P76129 (/IPI) P77334 (/IPI) P77334 (/IPI) P77334 (/IPI) P77334 (/IPI) P77334 (/IPI) P77334 (/IPI)
(18 more)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
24 P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA)
(14 more)
Bacterial-type RNA polymerase regulatory region sequence-specific DNA binding GO:0000984
Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase.
15 P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA) P21514 (/IDA)
(5 more)
Cyclic-guanylate-specific phosphodiesterase activity GO:0071111
Catalysis of the reaction: cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine + H(+).
8 Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
6 A0A0H3CDG5 (/IPI) A0A0H3CDG5 (/IPI) Q9HVI8 (/IPI) Q9HVI8 (/IPI) Q9HVI8 (/IPI) Q9HVI8 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
4 P76129 (/IMP) P76129 (/IMP) P76129 (/IMP) P76129 (/IMP)
Oxygen sensor activity GO:0019826
Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2).
4 P76129 (/IDA) P76129 (/IDA) P76129 (/IDA) P76129 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
4 P76129 (/IDA) P76129 (/IDA) P76129 (/IDA) P76129 (/IDA)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
3 O68318 (/ISS) O68318 (/ISS) O68318 (/ISS)
Diguanylate cyclase activity GO:0052621
Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H(+).
3 Q9I310 (/IDA) Q9I310 (/IDA) Q9I310 (/IDA)
Cyclic-nucleotide phosphodiesterase activity GO:0004112
Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
2 Q9Z584 (/IDA) Q9Z584 (/IDA)
Red or far-red light photoreceptor activity GO:0009883
The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation.
2 Q55434 (/TAS) Q55434 (/TAS)
3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
1 Q9I025 (/IDA)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
24 P77334 (/IMP) P77334 (/IMP) P77334 (/IMP) P77334 (/IMP) P77334 (/IMP) P77334 (/IMP) P77334 (/IMP) P77334 (/IMP) P77334 (/IMP) P77334 (/IMP)
(14 more)
Negative regulation of cyclase activity GO:0031280
Any process that stops or reduces the activity of a cyclase.
24 P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA) P77334 (/IDA)
(14 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
15 P21514 (/IMP) P21514 (/IMP) P21514 (/IMP) P21514 (/IMP) P21514 (/IMP) P21514 (/IMP) P21514 (/IMP) P21514 (/IMP) P21514 (/IMP) P21514 (/IMP)
(5 more)
Single-species biofilm formation GO:0044010
A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
8 Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP)
Negative regulation of single-species biofilm formation GO:1900191
Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation.
8 Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP) Q9HW35 (/IMP)
Response to oxygen levels GO:0070482
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
4 P76129 (/IMP) P76129 (/IMP) P76129 (/IMP) P76129 (/IMP)
Cellular response to nitric oxide GO:0071732
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
4 Q9HYT3 (/IMP) Q9I310 (/IMP) Q9I310 (/IMP) Q9I310 (/IMP)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
3 O68318 (/ISS) O68318 (/ISS) O68318 (/ISS)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
3 Q9HUF2 (/IMP) Q9HUF2 (/IMP) Q9HUF2 (/IMP)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
3 Q9HUF2 (/IMP) Q9HUF2 (/IMP) Q9HUF2 (/IMP)
Red, far-red light phototransduction GO:0009585
The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm.
2 Q55434 (/TAS) Q55434 (/TAS)
Protein-chromophore linkage GO:0018298
The covalent or noncovalent attachment of a chromophore to a protein.
2 Q55434 (/TAS) Q55434 (/TAS)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 Q9I025 (/IMP)
Regulation of single-species biofilm formation GO:1900190
Any process that modulates the frequency, rate or extent of single-species biofilm formation.
1 Q9I025 (/IDA)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P75995 (/IDA) P75995 (/IDA)