The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Enolase-like C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Enolase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
253 O51312 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI)
(243 more)
Phosphopyruvate hydratase activity GO:0004634
Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.
195 A4VWH9 (/IDA) O51312 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA)
(185 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
188 P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA)
(178 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
188 P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI)
(178 more)
Phosphopyruvate hydratase activity GO:0004634
Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.
50 B5LBH7 (/ISS) B5LBH7 (/ISS) B5LBH7 (/ISS) O51312 (/ISS) Q81X78 (/ISS) Q81X78 (/ISS) Q81X78 (/ISS) Q81X78 (/ISS) Q81X78 (/ISS) Q81X78 (/ISS)
(40 more)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
28 A0A0L0LUA6 (/IPI) A0A0L0LUA6 (/IPI) A0A0L0LUA6 (/IPI) A0A0L0LUA6 (/IPI) A0A0L0LUA6 (/IPI) A0A0L0LUA6 (/IPI) A0A0L0LUA6 (/IPI) A0A0L0LUA6 (/IPI) A0A0L0LUA6 (/IPI) A0A0L0LUA6 (/IPI)
(18 more)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
26 Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA)
(16 more)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
22 Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA) Q2G028 (/IDA)
(12 more)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
7 Q88YH3 (/IPI) Q88YH3 (/IPI) Q88YH3 (/IPI) Q88YH3 (/IPI) Q88YH3 (/IPI) Q88YH3 (/IPI) Q88YH3 (/IPI)
Phosphopyruvate hydratase activity GO:0004634
Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.
3 K1J238 (/IMP) K1J238 (/IMP) K1J238 (/IMP)
Zymogen binding GO:0035375
Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.
3 Q8DTS9 (/IPI) Q8DTS9 (/IPI) Q8DTS9 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 B5LBH7 (/ISS) B5LBH7 (/ISS) B5LBH7 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 A4VWH9 (/IDA)
Fibrinogen binding GO:0070051
Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.
1 A4VWH9 (/IPI)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
191 K1J238 (/IMP) K1J238 (/IMP) K1J238 (/IMP) P0A6P9 (/IMP) P0A6P9 (/IMP) P0A6P9 (/IMP) P0A6P9 (/IMP) P0A6P9 (/IMP) P0A6P9 (/IMP) P0A6P9 (/IMP)
(181 more)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
50 B5LBH7 (/ISS) B5LBH7 (/ISS) B5LBH7 (/ISS) O51312 (/ISS) Q81X78 (/ISS) Q81X78 (/ISS) Q81X78 (/ISS) Q81X78 (/ISS) Q81X78 (/ISS) Q81X78 (/ISS)
(40 more)
Interaction with host via substance in symbiont cell outer membrane GO:0044045
An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction.
5 Q9JZ53 (/IDA) Q9JZ53 (/IDA) Q9JZ53 (/IDA) Q9JZ53 (/IDA) Q9JZ53 (/IDA)
Interaction with host via substance in symbiont surface GO:0044044
An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
3 K1J238 (/IMP) K1J238 (/IMP) K1J238 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
3 B5LBH7 (/ISS) B5LBH7 (/ISS) B5LBH7 (/ISS)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
2 A4VWH9 (/IDA) O51312 (/IDA)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
1 O51312 (/IDA)
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
1 A4VWH9 (/IDA)
Modification by symbiont of host morphology or physiology GO:0044003
The process in which a symbiont organism effects a change in the structure or processes of its host organism.
1 O51312 (/IDA)
Interaction with host via substance in symbiont cell outer membrane GO:0044045
An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 A4VWH9 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 A4VWH9 (/IDA)
Positive regulation of fibrinolysis GO:0051919
Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
1 O51312 (/IDA)
Negative regulation by symbiont of entry into host cell via phagocytosis GO:0052067
Any process in which an organism stops or prevents itself undergoing phagocytosis into a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 A4VWH9 (/IMP)
Positive regulation by symbiont of host defense response GO:0052509
Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 A4VWH9 (/IDA)
Negative regulation of phagocytosis, engulfment GO:0060101
Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
1 A4VWH9 (/IMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
192 O51312 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA)
(182 more)
Phosphopyruvate hydratase complex GO:0000015
A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.
189 P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA) P0A6P9 (/IDA)
(179 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
188 P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA)
(178 more)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
188 P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI) P0A6P9 (/IPI)
(178 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
188 P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA) P0A6P9 (/HDA)
(178 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
67 A0A0L0LUA6 (/IDA) A0A0L0LUA6 (/IDA) A0A0L0LUA6 (/IDA) A0A0L0LUA6 (/IDA) A0A0L0LUA6 (/IDA) A0A0L0LUA6 (/IDA) A0A0L0LUA6 (/IDA) A0A0L0LUA6 (/IDA) A0A0L0LUA6 (/IDA) A0A0L0LUA6 (/IDA)
(57 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
8 A4VWH9 (/IDA) Q88YH3 (/IDA) Q88YH3 (/IDA) Q88YH3 (/IDA) Q88YH3 (/IDA) Q88YH3 (/IDA) Q88YH3 (/IDA) Q88YH3 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
6 P9WNL1 (/HDA) P9WNL1 (/HDA) P9WNL1 (/HDA) P9WNL1 (/HDA) P9WNL1 (/HDA) P9WNL1 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P9WNL1 (/HDA) P9WNL1 (/HDA) P9WNL1 (/HDA) P9WNL1 (/HDA) P9WNL1 (/HDA) P9WNL1 (/HDA)
External side of cell outer membrane GO:0031240
The side of the outer membrane that is opposite to the side that faces the periplasm of the cell.
6 O51312 (/IDA) Q9JZ53 (/IDA) Q9JZ53 (/IDA) Q9JZ53 (/IDA) Q9JZ53 (/IDA) Q9JZ53 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 A4VWH9 (/IDA) Q45RT9 (/IDA) Q8DTS9 (/IDA) Q8DTS9 (/IDA) Q8DTS9 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 Q8DTS9 (/IDA) Q8DTS9 (/IDA) Q8DTS9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 B5LBH7 (/ISS) B5LBH7 (/ISS) B5LBH7 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q5XD01 (/IDA)
External side of cell wall GO:0010339
The side of the cell wall that is opposite to the side that faces the cell and its contents.
1 Q45RT9 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O51312 (/IDA)