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CATH Superfamily 3.20.19.10

Aconitase, domain 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aconitase, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: 3-isopropylmalate dehydratase small subunit

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-isopropylmalate dehydratase. [EC: 4.2.1.33]
(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.
  • Forms part of the leucine-biosynthesis pathway.
  • Brings about the interconversion of the two isomers of isopropylmalate.
 12229 A0A023YSF7 A0A023YSF7 A0A023YSF7 A0A023YSF7 A0A023YSF7 A0A023YSF7 A0A023YSF7 A0A023YSF7 A0A023YSF7 A0A023YSF7
(12219 more...)
Homoaconitate hydratase. [EC: 4.2.1.36]
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4- tricarboxylate + H(2)O.
  • The enzyme from the hyperthermophilic eubacterium Thermus thermophilus can catalyze the reaction shown above but cannot catalyze the previously described reaction, i.e. formation of homocitrate by hydration of cis-homoaconitate.
  • The enzyme responsible for the conversion of cis-homoaconitate into homocitrate in T.thermophilus is unknown at present but the reaction can be catalyzed in vitro using EC 4.2.1.3 from pig.
 8 N1PAG0 N1PAG0 P49367 P49367 Q4WUL6 Q5A644 Q92412 Q9UT74