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CATH Superfamily 3.10.620.10

Protein N-terminal glutamine amidohydrolase, alpha beta roll

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Protein N-terminal glutamine amidohydrolase, alpha beta roll
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Protein N-terminal glutamine amidohydrolase. [EC: 3.5.1.122]
N-terminal L-glutaminyl-[protein] + H(2)O = N-terminal L-glutamyl- [protein] + NH(3).
  • This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln.
  • Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to L-glutamate.
  • The latter serves as a substrate for EC 2.3.2.8 making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.
 29 A0A0B4K882 A0A0E0PLX6 A0A0J9RDF7 A0A0Q9W0P2 A0A0Q9X7D5 A8Y183 B3MCF3 B3NQ86 B4HSF8 B4J8A0
(19 more...)