The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: Peptidylprolyl isomerase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
11 P27124 (/ISS) P30416 (/ISS) Q5RF88 (/ISS) Q64378 (/ISS) Q64378 (/ISS) Q95L05 (/ISS) Q9QVC8 (/ISS) Q9TRY0 (/ISS) Q9XSH5 (/ISS) Q9XSI2 (/ISS)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 P27124 (/IPI) P30416 (/IPI) Q02790 (/IPI) Q13451 (/IPI) Q64378 (/IPI) Q64378 (/IPI) Q9TRY0 (/IPI) Q9VL78 (/IPI) Q9VL78 (/IPI)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
3 O45418 (/IDA) Q02790 (/IDA) Q13451 (/IDA)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
3 P30416 (/ISO) Q64378 (/ISO) Q64378 (/ISO)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
3 P30416 (/ISO) Q64378 (/ISO) Q64378 (/ISO)
FK506 binding GO:0005528
Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506.
2 F1NIM4 (/IDA) Q5ZJT4 (/IDA)
FK506 binding GO:0005528
Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506.
2 Q9VL78 (/ISS) Q9VL78 (/ISS)
FK506 binding GO:0005528
Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506.
2 Q02790 (/TAS) Q13451 (/TAS)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
2 Q02790 (/IPI) Q13451 (/IPI)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
2 P27124 (/IPI) Q9QVC8 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q02790 (/HDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P30416 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P30416 (/IDA)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q02790 (/TAS)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
1 P30416 (/IDA)
Copper-dependent protein binding GO:0032767
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper.
1 Q9QVC8 (/IPI)
Copper-dependent protein binding GO:0032767
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper.
1 P30416 (/ISO)
Glucocorticoid receptor binding GO:0035259
Interacting selectively and non-covalently with a glucocorticoid receptor.
1 P30416 (/IDA)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
1 P30416 (/ISO)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
1 P30416 (/IDA)
Hsp90 protein binding GO:0051879
Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
1 O45418 (/IPI)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chaperone-mediated protein folding GO:0061077
The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.
11 P27124 (/ISS) P30416 (/ISS) Q5RF88 (/ISS) Q64378 (/ISS) Q64378 (/ISS) Q95L05 (/ISS) Q9QVC8 (/ISS) Q9TRY0 (/ISS) Q9XSH5 (/ISS) Q9XSI2 (/ISS)
(1 more)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
4 P30416 (/ISS) Q02790 (/ISS) Q9QVC8 (/ISS) Q9TRY0 (/ISS)
Negative regulation of microtubule polymerization or depolymerization GO:0031111
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.
4 P30416 (/ISS) Q02790 (/ISS) Q9QVC8 (/ISS) Q9TRY0 (/ISS)
Chaperone-mediated protein folding GO:0061077
The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.
3 P30416 (/ISO) Q64378 (/ISO) Q64378 (/ISO)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2 Q02790 (/TAS) Q13451 (/TAS)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
2 Q64378 (/IEP) Q64378 (/IEP)
Detection of light stimulus involved in visual perception GO:0050908
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
2 Q9VL78 (/IPI) Q9VL78 (/IPI)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9VL78 (/IDA) Q9VL78 (/IDA)
Chaperone-mediated protein folding GO:0061077
The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.
2 Q02790 (/IDA) Q13451 (/IDA)
Protein peptidyl-prolyl isomerization GO:0000413
The modification of a protein by cis-trans isomerization of a proline residue.
1 O45418 (/IDA)
Steroid hormone receptor complex assembly GO:0006463
The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor.
1 P30416 (/IDA)
Copper ion transport GO:0006825
The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9QVC8 (/IMP)
Copper ion transport GO:0006825
The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P30416 (/ISO)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
1 P30416 (/IMP)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P27124 (/IDA)
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
1 P30416 (/IMP)
Prostate gland development GO:0030850
The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.
1 P30416 (/IMP)
Negative regulation of microtubule polymerization or depolymerization GO:0031111
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.
1 P27124 (/IDA)
Negative regulation of microtubule polymerization GO:0031115
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.
1 Q9QVC8 (/IMP)
Negative regulation of microtubule polymerization GO:0031115
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.
1 P30416 (/ISO)
Protein-containing complex localization GO:0031503
A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.
1 P30416 (/IDA)
Male sex differentiation GO:0046661
The establishment of the sex of a male organism by physical differentiation.
1 P30416 (/IMP)
Reproductive structure development GO:0048608
The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.
1 P30416 (/IMP)
Regulation of cellular response to heat GO:1900034
Any process that modulates the frequency, rate or extent of cellular response to heat.
1 Q02790 (/TAS)

There are 24 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P27124 (/ISS) P30416 (/ISS) Q02790 (/ISS) Q9TRY0 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q02790 (/TAS) Q13451 (/TAS) Q64378 (/TAS) Q64378 (/TAS)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
4 P27124 (/ISS) P30416 (/ISS) Q02790 (/ISS) Q9TRY0 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 P30416 (/ISO) Q64378 (/ISO) Q64378 (/ISO)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
2 F1NIM4 (/IDA) Q5ZJT4 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q02790 (/IDA) Q13451 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q02790 (/IDA) Q9QVC8 (/IDA)
InaD signaling complex GO:0016027
A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.
2 Q9VL78 (/IPI) Q9VL78 (/IPI)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q02790 (/HDA) Q13451 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P30416 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q02790 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q02790 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P30416 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q13451 (/HDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9QVC8 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P30416 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9QVC8 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P30416 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9QVC8 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P30416 (/ISO)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
1 Q9QVC8 (/IDA)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
1 P30416 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q9QVC8 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P30416 (/ISO)