The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Mediator complex, subunit Med6

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Mediator complex, subunit Med6

Structural domains comprising this superfamily share the structure of subunit 6 of the mediator complex, a co-activator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator connects transcriptional regulators and Pol II. This mediator complex is comprised of several subunits, the number of these varies between organisms, which form the head, middle, tail and kinase modules. The cited subunit 6 is a conserved subunit of the head module. The head module interacts with Pol II and this contact is required for regulated transcription PMID:23123849.

GO Diversity

Unique GO annotations
23 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1396 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 2
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 22
Unique EC:
Unique GO: 23
Unique Species: 1396