The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Histidine-rich glycoprotein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P04196 (/IPI) Q28640 (/IPI) Q9ESB3 (/IPI)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Immunoglobulin binding GO:0019865
Interacting selectively and non-covalently with an immunoglobulin.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Serine-type endopeptidase inhibitor activity GO:0004867
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
1 Q9ESB3 (/IMP)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P04196 (/IDA)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
1 P04196 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 P04196 (/IDA)
Immunoglobulin binding GO:0019865
Interacting selectively and non-covalently with an immunoglobulin.
1 P04196 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 P04196 (/IDA)
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
1 P04196 (/IDA)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
1 P04196 (/IDA)

There are 60 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Regulation of platelet activation GO:0010543
Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
3 P04196 (/ISS) Q28640 (/ISS) Q99PS8 (/ISS)
Negative regulation of lamellipodium assembly GO:0010593
Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Negative regulation of cell adhesion mediated by integrin GO:0033629
Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Regulation of protein complex assembly GO:0043254
Any process that modulates the frequency, rate or extent of protein complex assembly.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Negative regulation of blood vessel endothelial cell migration GO:0043537
Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
3 P04196 (/ISS) Q28640 (/ISS) Q99PS8 (/ISS)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Positive regulation of focal adhesion assembly GO:0051894
Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Negative regulation of vascular endothelial growth factor signaling pathway GO:1900747
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Negative regulation of endothelial cell chemotaxis GO:2001027
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis.
3 Q28640 (/ISS) Q99PS8 (/ISS) Q9ESB3 (/ISS)
Positive regulation of immune response to tumor cell GO:0002839
Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.
2 Q28640 (/ISS) Q99PS8 (/ISS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q28640 (/ISS) Q99PS8 (/ISS)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
2 P04196 (/IDA) Q28640 (/IDA)
Regulation of blood coagulation GO:0030193
Any process that modulates the frequency, rate or extent of blood coagulation.
2 Q28640 (/ISS) Q99PS8 (/ISS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
2 P04196 (/IDA) Q9ESB3 (/IDA)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
2 Q28640 (/ISS) Q99PS8 (/ISS)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
2 Q28640 (/ISS) Q99PS8 (/ISS)
Positive regulation of blood vessel remodeling GO:2000504
Any process that activates or increases the frequency, rate or extent of blood vessel remodeling.
2 Q28640 (/ISS) Q99PS8 (/ISS)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
1 P04196 (/TAS)
Positive regulation of immune response to tumor cell GO:0002839
Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.
1 P04196 (/IDA)
Positive regulation of immune response to tumor cell GO:0002839
Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.
1 Q9ESB3 (/IMP)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
1 P04196 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P04196 (/IDA)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P04196 (/IDA)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9ESB3 (/IMP)
Regulation of platelet activation GO:0010543
Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
1 Q9ESB3 (/IMP)
Negative regulation of lamellipodium assembly GO:0010593
Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
1 P04196 (/IDA)
Regulation of plasminogen activation GO:0010755
Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
1 Q28640 (/IDA)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q9ESB3 (/IDA)
Heme transport GO:0015886
The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9ESB3 (/IMP)
Heme transport GO:0015886
The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9ESB3 (/ISO)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 Q9ESB3 (/IMP)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 Q99PS8 (/ISS)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
1 P04196 (/IDA)
Regulation of blood coagulation GO:0030193
Any process that modulates the frequency, rate or extent of blood coagulation.
1 P04196 (/IDA)
Regulation of blood coagulation GO:0030193
Any process that modulates the frequency, rate or extent of blood coagulation.
1 Q9ESB3 (/IMP)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 P04196 (/IDA)
Negative regulation of cell adhesion mediated by integrin GO:0033629
Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin.
1 P04196 (/IDA)
Regulation of transcription from RNA polymerase II promoter in response to iron GO:0034395
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus.
1 Q9ESB3 (/IDA)
Fibrinolysis GO:0042730
A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
1 P04196 (/TAS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P04196 (/IDA)
Regulation of protein complex assembly GO:0043254
Any process that modulates the frequency, rate or extent of protein complex assembly.
1 P04196 (/IDA)
Negative regulation of blood vessel endothelial cell migration GO:0043537
Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
1 Q9ESB3 (/IMP)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 P04196 (/IDA)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
1 P04196 (/IDA)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
1 Q9ESB3 (/IMP)
Cytolysis in other organism GO:0051715
The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm.
1 P04196 (/IDA)
Positive regulation of focal adhesion assembly GO:0051894
Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
1 P04196 (/IDA)
Negative regulation of fibrinolysis GO:0051918
Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
1 Q9ESB3 (/IMP)
Antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844
An immune response against microbes mediated by anti-microbial peptides in body fluid.
1 P04196 (/IDA)
Antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844
An immune response against microbes mediated by anti-microbial peptides in body fluid.
1 Q9ESB3 (/IMP)
Heme export GO:0097037
The directed movement of heme out of a cell or organelle.
1 Q9ESB3 (/IMP)
Negative regulation of vascular endothelial growth factor signaling pathway GO:1900747
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway.
1 P04196 (/IDA)
Positive regulation of blood vessel remodeling GO:2000504
Any process that activates or increases the frequency, rate or extent of blood vessel remodeling.
1 P04196 (/IDA)
Positive regulation of blood vessel remodeling GO:2000504
Any process that activates or increases the frequency, rate or extent of blood vessel remodeling.
1 Q9ESB3 (/IMP)
Negative regulation of endothelial cell chemotaxis GO:2001027
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis.
1 P04196 (/IDA)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
2 P04196 (/HDA) Q9ESB3 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P04196 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P04196 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P04196 (/NAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P04196 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P04196 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P04196 (/IDA)
Platelet alpha granule lumen GO:0031093
The volume enclosed by the membrane of the platelet alpha granule.
1 P04196 (/TAS)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 Q9ESB3 (/IDA)
Endolysosome GO:0036019
An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.
1 Q9ESB3 (/IDA)
Phagolysosome membrane GO:0061474
The lipid bilayer surrounding a phagolysosome.
1 Q9ESB3 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P04196 (/HDA)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
1 P04196 (/HDA)