The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Cell division control 48

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 45 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
92 P23787 (/IPI) P25694 (/IPI) P25694 (/IPI) P25694 (/IPI) P46462 (/IPI) P54609 (/IPI) P54609 (/IPI) P54609 (/IPI) P54811 (/IPI) P54812 (/IPI)
(82 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
58 P25694 (/IPI) P25694 (/IPI) P25694 (/IPI) P54609 (/IPI) P54609 (/IPI) P54609 (/IPI) P54811 (/IPI) P54812 (/IPI) P55072 (/IPI) P55072 (/IPI)
(48 more)
Polyubiquitin modification-dependent protein binding GO:0031593
Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein.
50 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(40 more)
Ubiquitin-specific protease binding GO:1990381
Interacting selectively and non-covalently with a ubiquitin-specific protease.
50 P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI)
(40 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
37 O44008 (/IDA) O44008 (/IDA) O44008 (/IDA) P23787 (/IDA) P25694 (/IDA) P25694 (/IDA) P25694 (/IDA) P46462 (/IDA) P54811 (/IDA) P54812 (/IDA)
(27 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
26 P46462 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA)
(16 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
26 P46462 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP)
(16 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
26 P46462 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(16 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
26 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(16 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
26 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(16 more)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
26 P46462 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP)
(16 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
25 P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA)
(15 more)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
25 P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI)
(15 more)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
25 P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI)
(15 more)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Polyubiquitin modification-dependent protein binding GO:0031593
Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
25 P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI)
(15 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Deubiquitinase activator activity GO:0035800
Increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Deubiquitinase activator activity GO:0035800
Increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
K48-linked polyubiquitin modification-dependent protein binding GO:0036435
Interacting selectively and non-covalently with a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.
25 Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA)
(15 more)
MHC class I protein binding GO:0042288
Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
25 Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA)
(15 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
25 Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP)
(15 more)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Ubiquitin-like protein ligase binding GO:0044389
Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase.
25 P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI)
(15 more)
Ubiquitin-like protein ligase binding GO:0044389
Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
BAT3 complex binding GO:1904288
Interacting selectively and non-covalently with a BAT3 complex.
25 P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI) P55072 (/IPI)
(15 more)
BAT3 complex binding GO:1904288
Interacting selectively and non-covalently with a BAT3 complex.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Ubiquitin-specific protease binding GO:1990381
Interacting selectively and non-covalently with a ubiquitin-specific protease.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
6 O44008 (/IDA) O44008 (/IDA) O44008 (/IDA) P46462 (/IDA) Q38B27 (/IDA) Q38B27 (/IDA)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
5 P03974 (/ISS) P90532 (/ISS) Q3ZBT1 (/ISS) Q6GL04 (/ISS) Q7ZU99 (/ISS)
Protein phosphatase regulator activity GO:0019888
Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
3 P25694 (/IDA) P25694 (/IDA) P25694 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 P23787 (/IPI) P46462 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P46462 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q6GL04 (/ISS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 Q9P3A7 (/ISM)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q9P3A7 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P54811 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q6GL04 (/ISS)

There are 182 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Retrograde protein transport, ER to cytosol GO:0030970
The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
53 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(43 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
53 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(43 more)
Positive regulation of mitochondrial membrane potential GO:0010918
Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
50 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(40 more)
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
32 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) P90532 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(22 more)
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Protein N-linked glycosylation via asparagine GO:0018279
The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Translesion synthesis GO:0019985
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Endosome to lysosome transport via multivesicular body sorting pathway GO:0032510
The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
ERAD pathway GO:0036503
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Autophagosome maturation GO:0097352
Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
30 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(20 more)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
30 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(20 more)
Stress granule disassembly GO:0035617
The disaggregation of a stress granule into its constituent protein and RNA parts.
30 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(20 more)
Endoplasmic reticulum stress-induced pre-emptive quality control GO:0061857
The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome.
30 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(20 more)
Cellular response to arsenite ion GO:1903843
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus.
30 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(20 more)
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
28 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(18 more)
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
28 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(18 more)
ER-associated misfolded protein catabolic process GO:0071712
The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
28 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(18 more)
Protein hexamerization GO:0034214
The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
27 P23787 (/IDA) P46462 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA)
(17 more)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
26 Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI)
(16 more)
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
26 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(16 more)
Retrograde protein transport, ER to cytosol GO:0030970
The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
26 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(16 more)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
26 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(16 more)
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
26 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(16 more)
Autophagosome maturation GO:0097352
Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
26 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(16 more)
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
25 P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS)
(15 more)
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
NADH metabolic process GO:0006734
The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
NADH metabolic process GO:0006734
The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
25 Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA)
(15 more)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
25 P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS)
(15 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Positive regulation of mitochondrial membrane potential GO:0010918
Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
25 P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS)
(15 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Protein N-linked glycosylation via asparagine GO:0018279
The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Protein N-linked glycosylation via asparagine GO:0018279
The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Viral genome replication GO:0019079
Any process involved directly in viral genome replication, including viral nucleotide metabolism.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Viral genome replication GO:0019079
Any process involved directly in viral genome replication, including viral nucleotide metabolism.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Translesion synthesis GO:0019985
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Translesion synthesis GO:0019985
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Retrograde protein transport, ER to cytosol GO:0030970
The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Retrograde protein transport, ER to cytosol GO:0030970
The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
25 Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(15 more)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Endosome to lysosome transport via multivesicular body sorting pathway GO:0032510
The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Endosome to lysosome transport via multivesicular body sorting pathway GO:0032510
The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Protein hexamerization GO:0034214
The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
25 Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP)
(15 more)
Protein hexamerization GO:0034214
The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Stress granule disassembly GO:0035617
The disaggregation of a stress granule into its constituent protein and RNA parts.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Stress granule disassembly GO:0035617
The disaggregation of a stress granule into its constituent protein and RNA parts.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
ERAD pathway GO:0036503
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
ERAD pathway GO:0036503
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
ERAD pathway GO:0036503
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
25 P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS) P55072 (/NAS)
(15 more)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
25 Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA)
(15 more)
Regulation of synapse organization GO:0050807
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Endoplasmic reticulum stress-induced pre-emptive quality control GO:0061857
The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Endoplasmic reticulum stress-induced pre-emptive quality control GO:0061857
The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Aggresome assembly GO:0070842
The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein.
25 Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI) Q01853 (/IGI)
(15 more)
Error-free translesion synthesis GO:0070987
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
ER-associated misfolded protein catabolic process GO:0071712
The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Flavin adenine dinucleotide catabolic process GO:0072389
The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Flavin adenine dinucleotide catabolic process GO:0072389
The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Autophagosome maturation GO:0097352
Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Positive regulation of protein K63-linked deubiquitination GO:1903006
Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Positive regulation of protein K63-linked deubiquitination GO:1903006
Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Positive regulation of Lys63-specific deubiquitinase activity GO:1903007
Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Positive regulation of Lys63-specific deubiquitinase activity GO:1903007
Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Regulation of aerobic respiration GO:1903715
Any process that modulates the frequency, rate or extent of aerobic respiration.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Regulation of aerobic respiration GO:1903715
Any process that modulates the frequency, rate or extent of aerobic respiration.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Cellular response to arsenite ion GO:1903843
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Cellular response to arsenite ion GO:1903843
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Positive regulation of oxidative phosphorylation GO:1903862
Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Positive regulation of oxidative phosphorylation GO:1903862
Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
25 P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP) P55072 (/IMP)
(15 more)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
4 P54609 (/IEP) P54609 (/IEP) P54609 (/IEP) Q9SCN8 (/IEP)
Mitotic spindle disassembly GO:0051228
The controlled breakdown of the spindle during a mitotic cell cycle.
4 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP) Q9P3A7 (/IMP)
Pollen germination GO:0009846
The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture.
3 P54609 (/IMP) P54609 (/IMP) P54609 (/IMP)
Pollen tube growth GO:0009860
Growth of pollen via tip extension of the intine wall.
3 P54609 (/IMP) P54609 (/IMP) P54609 (/IMP)
Positive regulation of mitochondrial fusion GO:0010636
Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Endoplasmic reticulum membrane fusion GO:0016320
The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Sister chromatid biorientation GO:0031134
The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Negative regulation of defense response GO:0031348
Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.
3 P54609 (/IMP) P54609 (/IMP) P54609 (/IMP)
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
3 P54609 (/IMP) P54609 (/IMP) P54609 (/IMP)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
3 P46462 (/IMP) P54811 (/IMP) Q7KN62 (/IMP)
Ribophagy GO:0034517
The selective autophagy process in which cells degrade mature ribosomes under conditions of starvation.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Piecemeal microautophagy of the nucleus GO:0034727
Degradation of a cell nucleus by lysosomal microautophagy.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043328
The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.
3 P25694 (/IGI) P25694 (/IGI) P25694 (/IGI)
Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043328
The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Cellular protein complex disassembly GO:0043624
The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.
3 P25694 (/IGI) P25694 (/IGI) P25694 (/IGI)
Cellular protein complex disassembly GO:0043624
The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
3 P54609 (/IMP) P54609 (/IMP) P54609 (/IMP)
Negative regulation of telomerase activity GO:0051974
Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Nonfunctional rRNA decay GO:0070651
An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Cytoplasm protein quality control by the ubiquitin-proteasome system GO:0071629
The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Nuclear protein quality control by the ubiquitin-proteasome system GO:0071630
The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Mitochondria-associated ubiquitin-dependent protein catabolic process GO:0072671
The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Stress-induced homeostatically regulated protein degradation pathway GO:0120174
A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Ribosome-associated ubiquitin-dependent protein catabolic process GO:1990116
The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
SCF complex disassembly in response to cadmium stress GO:1990171
The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Positive regulation of histone H2B ubiquitination GO:2001168
Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination.
3 P25694 (/IMP) P25694 (/IMP) P25694 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
2 P54811 (/IGI) P54812 (/IGI)
ER-associated misfolded protein catabolic process GO:0071712
The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
2 P54811 (/IGI) P54812 (/IGI)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 Q7KN62 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 Q7KN62 (/IMP)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 Q7KN62 (/IMP)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 P90532 (/ISS)
Asparagine catabolic process GO:0006530
The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid.
1 Q7KN62 (/IMP)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
1 P46462 (/IMP)
Endoplasmic reticulum organization GO:0007029
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
1 Q7KN62 (/IMP)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
1 Q7KN62 (/IMP)
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
1 Q7KN62 (/IMP)
Pole cell formation GO:0007279
Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells.
1 Q7KN62 (/IGI)
Regulation of pole plasm oskar mRNA localization GO:0007317
Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.
1 Q7KN62 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 Q7ZU99 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 P54811 (/IMP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 P90532 (/HEP)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q7ZU99 (/IMP)
Endoplasmic reticulum membrane fusion GO:0016320
The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.
1 Q7KN62 (/ISS)
Asexual reproduction GO:0019954
The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process.
1 P90532 (/IMP)
Regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434
Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q7ZU99 (/IMP)
Protein localization to Golgi apparatus GO:0034067
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
1 Q9P3A7 (/IMP)
Protein hexamerization GO:0034214
The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
1 Q6GL04 (/ISS)
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
1 P54812 (/IDA)
Larval midgut cell programmed cell death GO:0035096
The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ.
1 Q7KN62 (/IMP)
Sterol regulatory element binding protein cleavage GO:0035103
The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids.
1 Q9P3A7 (/IMP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
1 Q7ZU99 (/IMP)
Regulation of neuron apoptotic process GO:0043523
Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.
1 Q7KN62 (/IMP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
1 Q7KN62 (/IMP)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
1 Q7KN62 (/IMP)
Positive regulation of mitotic cell cycle, embryonic GO:0045977
Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle.
1 P54811 (/IGI)
Positive regulation of viral entry into host cell GO:0046598
Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell.
1 Q7KN62 (/IMP)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
1 Q7KN62 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
1 Q7KN62 (/IMP)
Regulation of synapse organization GO:0050807
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 P46462 (/IDA)
Regulation of synapse organization GO:0050807
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 P46462 (/IMP)
Mitotic spindle disassembly GO:0051228
The controlled breakdown of the spindle during a mitotic cell cycle.
1 Q4Q1T9 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P46462 (/IDA)
Mitotic sister chromatid separation GO:0051306
The process in which sister chromatids are physically detached from each other during mitosis.
1 Q9P3A7 (/IMP)
Establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site GO:0061166
The directed movement of the endoplasmic reticulum to the site where a cell will divide.
1 Q9P3A7 (/IMP)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q7KN62 (/IMP)
Cellular response to virus GO:0098586
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q7KN62 (/IMP)
Negative regulation of protein localization to centrosome GO:1904780
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome.
1 P54812 (/IMP)
Regulation of protein localization to chromatin GO:1905634
Any process that modulates the frequency, rate or extent of protein localization to chromatin.
1 P54811 (/IGI)
Ribosome-associated ubiquitin-dependent protein catabolic process GO:1990116
The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein.
1 Q9P3A7 (/ISO)
Regulation of ubiquitin-dependent protein catabolic process GO:2000058
Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
1 Q7ZU99 (/IMP)

There are 99 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
62 C9IZA5 (/IDA) C9IZA5 (/IDA) P25694 (/IDA) P25694 (/IDA) P25694 (/IDA) P46462 (/IDA) P54609 (/IDA) P54609 (/IDA) P54609 (/IDA) P55072 (/IDA)
(52 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
59 C9IZA5 (/IDA) C9IZA5 (/IDA) O44008 (/IDA) O44008 (/IDA) O44008 (/IDA) P54811 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(49 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
53 P25694 (/IDA) P25694 (/IDA) P25694 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(43 more)
Derlin-1 retrotranslocation complex GO:0036513
A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.
50 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(40 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
38 O44008 (/IDA) O44008 (/IDA) O44008 (/IDA) P23787 (/IDA) P54609 (/IDA) P54609 (/IDA) P54609 (/IDA) P54811 (/IDA) P55072 (/IDA) P55072 (/IDA)
(28 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
35 P23787 (/IDA) P25694 (/IDA) P25694 (/IDA) P25694 (/IDA) P54609 (/IDA) P54609 (/IDA) P54609 (/IDA) P54811 (/IDA) P54812 (/IDA) P55072 (/IDA)
(25 more)
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
31 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(21 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
30 P25694 (/HDA) P25694 (/HDA) P25694 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA)
(20 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
30 P03974 (/ISS) P23787 (/ISS) P46462 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(20 more)
VCP-NPL4-UFD1 AAA ATPase complex GO:0034098
A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
30 P25694 (/IDA) P25694 (/IDA) P25694 (/IDA) P46462 (/IDA) P54811 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA)
(20 more)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
28 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(18 more)
VCP-NPL4-UFD1 AAA ATPase complex GO:0034098
A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
27 P54811 (/IPI) P54812 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI)
(17 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
26 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(16 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
26 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(16 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
26 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(16 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
26 P46462 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(16 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
26 P90532 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(16 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
26 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(16 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
26 P54811 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(16 more)
VCP-NSFL1C complex GO:1990730
A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
26 P46462 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI)
(16 more)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
25 Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS) Q01853 (/ISS)
(15 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
25 Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI) Q01853 (/IPI)
(15 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
VCP-NPL4-UFD1 AAA ATPase complex GO:0034098
A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
VCP-NPL4-UFD1 AAA ATPase complex GO:0034098
A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
25 P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS)
(15 more)
VCP-NPL4-UFD1 AAA ATPase complex GO:0034098
A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
25 P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA) P55072 (/IDA)
(15 more)
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Derlin-1 retrotranslocation complex GO:0036513
A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
25 Q01853 (/HDA) Q01853 (/HDA) Q01853 (/HDA) Q01853 (/HDA) Q01853 (/HDA) Q01853 (/HDA) Q01853 (/HDA) Q01853 (/HDA) Q01853 (/HDA) Q01853 (/HDA)
(15 more)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
25 P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS)
(15 more)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
25 Q01853 (/EXP) Q01853 (/EXP) Q01853 (/EXP) Q01853 (/EXP) Q01853 (/EXP) Q01853 (/EXP) Q01853 (/EXP) Q01853 (/EXP) Q01853 (/EXP) Q01853 (/EXP)
(15 more)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
25 Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA) Q01853 (/IDA)
(15 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
25 P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA) P55072 (/HDA)
(15 more)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
25 P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS) P55072 (/TAS)
(15 more)
ATPase complex GO:1904949
A protein complex which is capable of ATPase activity.
25 Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP) Q01853 (/IMP)
(15 more)
VCP-NSFL1C complex GO:1990730
A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
25 Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO) Q01853 (/ISO)
(15 more)
VCP-NSFL1C complex GO:1990730
A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
25 P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS) P55072 (/ISS)
(15 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA) Q59WG3 (/IDA) Q59WG3 (/IDA) Q9SCN8 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
5 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA) Q9LZF6 (/IDA) Q9SCN8 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 O44008 (/IDA) O44008 (/IDA) O44008 (/IDA) Q38B27 (/IDA) Q38B27 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
4 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA) Q9LZF6 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
4 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA) Q9SCN8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P03974 (/ISS) Q3ZBT1 (/ISS) Q6GL04 (/ISS) Q7ZU99 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P25694 (/HDA) P25694 (/HDA) P25694 (/HDA) Q9P3A7 (/HDA)
Doa10p ubiquitin ligase complex GO:0000837
A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p.
3 P25694 (/IDA) P25694 (/IDA) P25694 (/IDA)
Hrd1p ubiquitin ligase ERAD-L complex GO:0000839
A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
3 P25694 (/IDA) P25694 (/IDA) P25694 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
3 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P25694 (/HDA) P25694 (/HDA) P25694 (/HDA)
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
3 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
3 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA)
Phragmoplast GO:0009524
Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules.
3 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA)
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
3 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA)
Cdc48p-Npl4p-Vms1p AAA ATPase complex GO:0036266
A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p.
3 P25694 (/IDA) P25694 (/IDA) P25694 (/IDA)
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
3 P25694 (/HDA) P25694 (/HDA) P25694 (/HDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
3 P54609 (/IDA) P54609 (/IDA) P54609 (/IDA)
RQC complex GO:1990112
A multiprotein complex that forms a stable complex with 60S ribosomal subunits containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins.
3 P25694 (/IDA) P25694 (/IDA) P25694 (/IDA)
RQC complex GO:1990112
A multiprotein complex that forms a stable complex with 60S ribosomal subunits containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins.
3 P25694 (/IPI) P25694 (/IPI) P25694 (/IPI)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q59WG3 (/IDA) Q59WG3 (/IDA)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
1 Q7KN62 (/NAS)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 P23787 (/IDA)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 Q6GL04 (/ISS)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q9P3A7 (/IDA)
Hrd1p ubiquitin ligase complex GO:0000836
A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).
1 Q9P3A7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6GL04 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q7KN62 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q7KN62 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q4Q1T9 (/ISO)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 P90532 (/HDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 Q7KN62 (/HDA)
Cdc48p-Npl4p-Vms1p AAA ATPase complex GO:0036266
A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p.
1 Q9P3A7 (/ISO)
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
1 Q7KN62 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P46462 (/IDA)
Autolysosome GO:0044754
A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases.
1 Q7KN62 (/IDA)
Fusome GO:0045169
A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle.
1 Q7KN62 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 P90532 (/HDA)
Cytoplasmic side of endoplasmic reticulum membrane GO:0098554
The side (leaflet) of the plasma membrane that faces the cytoplasm.
1 Q4Q1T9 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P46462 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P46462 (/IMP)
Mitotic spindle midzone GO:1990023
The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.
1 Q9P3A7 (/IDA)
RQC complex GO:1990112
A multiprotein complex that forms a stable complex with 60S ribosomal subunits containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins.
1 Q9P3A7 (/ISO)