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CATH Superfamily 3.10.290.10

RNA-binding S4 domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
RNA-binding S4 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Tyrosine--tRNA ligase. [EC: 6.1.1.1]
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).
    		 1165 A0A015P3E9 A0A015TW51 A0A015U8E7 A0A015XAD9 A0A015YJU8 A0A016AQY8 A0A016EED9 A0A016JSP0 A0A017NJZ9 A0A017PGP3
    (1155 more...)
    23S rRNA pseudouridine(2605) synthase. [EC: 5.4.99.22]
    23S rRNA uridine(2605) = 23S rRNA pseudouridine(2605).
    • Pseudouridine synthase RluB converts uridine(2605) of 23S rRNA to pseudouridine.
    		 305 A0A026V025 A0A028ABV9 A0A028E5I7 A0A063XBL4 A0A069QC38 A0A070FGM4 A0A070SMG9 A0A070VAD6 A0A072FP18 A0A073FZ27
    (295 more...)
    16S rRNA pseudouridine(516) synthase. [EC: 5.4.99.19]
    16S rRNA uridine(516) = 16S rRNA pseudouridine(516).
    • The enzyme is specific for uridine(516) in 16S rRNA.
    • In vitro, the enzyme does not modify free 16S rRNA.
    • The preferred substrate is a 5'-terminal fragment of 16S rRNA complexed with 30S ribosomal proteins.
    		 251 A0A023Z039 A0A025CH14 A0A026ULA9 A0A028A127 A0A028DKL5 A0A069XT62 A0A070FPU3 A0A070SUQ5 A0A070UUR1 A0A073HDU0
    (241 more...)
    23S rRNA pseudouridine(1911/1915/1917) synthase. [EC: 5.4.99.23]
    23S rRNA uridine(1911)/uridine(1915)/uridine(1917) = 23S rRNA pseudouridine(1911)/pseudouridine(1915)/pseudouridine(1917).
    • Pseudouridine synthase RluD converts uridines at positions 1911, 1915, and 1917 of 23S rRNA to pseudouridines.
    • These nucleotides are located in the functionally important helix- loop 69 of 23S rRNA.
    		 231 A0A026UEB2 A0A069Q6S5 A0A069XKB0 A0A070V7R1 A0A072IYW7 A0A073FRQ0 A0A074HS92 A0A080FRH5 A0A0A0FCL3 A0A0A8F4D6
    (221 more...)
    23S rRNA pseudouridine(955/2504/2580) synthase. [EC: 5.4.99.24]
    23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580).
    • The enzyme converts uridines at position 955, 2504 and 2580 of 23S rRNA to pseudouridines.
    		 211 A0A023YW94 A0A025C6T2 A0A026V8D8 A0A027ZNB4 A0A028EC08 A0A069XMQ2 A0A070FHB1 A0A070T185 A0A070V341 A0A072H4D9
    (201 more...)
    23S rRNA pseudouridine(2604) synthase. [EC: 5.4.99.21]
    23S rRNA uridine(2604) = 23S rRNA pseudouridine(2604).
    • The enzyme is not completely specific for uridine(2604) and can, to a small extent, also react with uridine(2605).
    		 104 A0A024L713 A0A029HCP4 A0A029IGN4 A0A069XFN2 A0A070FJ94 A0A070SZV8 A0A070UVP8 A0A077ZJ21 A0A080IF42 A0A0D6HKA1
    (94 more...)