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CATH Superfamily 3.10.270.10

Urate Oxidase;

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Urate Oxidase;
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
GTP cyclohydrolase I. [EC: 3.5.4.16]
GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)-dihydropteridine triphosphate.
  • The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic.
  • Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.
 264 A0A069BB45 A0A071ML72 A0A0A8F411 A0A0C6P1D3 A0A0D1FSK9 A0A0D5NCX7 A0A0E0VMC4 A0A0E1AHT1 A0A0E1UPX2 A0A0E1VF24
(254 more...)
GTP cyclohydrolase IV. [EC: 3.5.4.39]
GTP + H(2)O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.
  • The enzyme is involved in methanopterin biosynthesis in methanogenic archaea.
  • Cf. EC 3.5.4.16, EC 3.5.4.25 and EC 3.5.4.29.
  • Formerly EC 3.5.4.n2.
 58 A0A075WG65 A0A0E3LRI4 A0A0E3LTC6 A0A0E3PV97 A0A0E3QR16 A0A0E3RLB8 A0A0E3RSQ6 A0A0F8Q834 A0A1D2WI64 A0A1D2WVG6
(48 more...)
Factor independent urate hydroxylase. [EC: 1.7.3.3]
Urate + O(2) + H(2)O = 5-hydroxyisourate + H(2)O(2).
  • Was previously thought to be a copper protein, but it is now known that the enzymes from soybean (Glycine max), the mold Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion.
  • The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO(2), although there is an enzyme-catalyzed pathway in which EC 3.5.2.17 catalyzes the first step.
  • The enzyme is different from EC 1.14.13.113.
 44 A0A164TNZ2 A0A1B2AYV6 A0A1S9DDE4 A0A2P2HQU8 A0A364MCW7 A0A481AJD3 B8NB34 D0VWQ1 D4GPU7 D8JBB7
(34 more...)
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. [EC: 4.1.1.97]
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)- allantoin + CO(2).
  • This enzyme is part of the pathway from urate to (S)-allantoin, which is present in bacteria, plants and animals (but not in humans).
  • Formerly EC 4.1.1.n1.
 5 A0A164TNZ2 A0A1B2AYV6 L8ATQ3 O32141 Q45697