The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 267: Blast:Serine/threonine-protein kinase TBK1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
4 Q7KJQ4 (/IDA) Q86PE7 (/IDA) Q86PE7 (/IDA) Q9V3Y8 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q7KJQ4 (/IPI) Q86PE7 (/IPI) Q86PE7 (/IPI) Q9V3Y8 (/IPI)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
4 Q7KJQ4 (/IPI) Q86PE7 (/IPI) Q86PE7 (/IPI) Q9V3Y8 (/IPI)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)
Oocyte anterior/posterior axis specification GO:0007314
Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)
Chaeta morphogenesis GO:0008407
The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
4 Q7KJQ4 (/IDA) Q86PE7 (/IDA) Q86PE7 (/IDA) Q9V3Y8 (/IDA)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)
Maintenance of epithelial integrity, open tracheal system GO:0035160
Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process.
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)
Protein trans-autophosphorylation GO:0036290
The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer.
4 Q7KJQ4 (/IDA) Q86PE7 (/IDA) Q86PE7 (/IDA) Q9V3Y8 (/IDA)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)
Sensory organ precursor cell division GO:0045035
The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron).
4 Q7KJQ4 (/IGI) Q86PE7 (/IGI) Q86PE7 (/IGI) Q9V3Y8 (/IGI)
Regulation of cytoskeleton organization GO:0051493
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
4 Q7KJQ4 (/IPI) Q86PE7 (/IPI) Q86PE7 (/IPI) Q9V3Y8 (/IPI)
Actin filament bundle organization GO:0061572
A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.
4 Q7KJQ4 (/IMP) Q86PE7 (/IMP) Q86PE7 (/IMP) Q9V3Y8 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q7KJQ4 (/IDA) Q86PE7 (/IDA) Q86PE7 (/IDA) Q9V3Y8 (/IDA)
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
4 Q7KJQ4 (/IDA) Q86PE7 (/IDA) Q86PE7 (/IDA) Q9V3Y8 (/IDA)