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CATH Superfamily 3.10.20.90

Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: Small ubiquitin-related modifier

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
 276 P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS)
(266 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 95 P55854 (/IPI) P55854 (/IPI) P55854 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI)
(85 more)
SUMO transferase activity GO:0019789
Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.
 47 P61957 (/IDA) P61957 (/IDA) P61957 (/IDA) P61957 (/IDA) P61957 (/IDA) P61957 (/IDA) P61957 (/IDA) P61957 (/IDA) P61957 (/IDA) P61957 (/IDA)
(37 more)
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
 46 P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI)
(36 more)
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
 46 P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO)
(36 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
 46 P61956 (/HDA) P61956 (/HDA) P61956 (/HDA) P61956 (/HDA) P61956 (/HDA) P61956 (/HDA) P61956 (/HDA) P61956 (/HDA) P61956 (/HDA) P61956 (/HDA)
(36 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
 46 P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI) P61956 (/IPI)
(36 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
 46 P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO)
(36 more)
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
 46 P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA)
(36 more)
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
 46 P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO)
(36 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
 3 P55854 (/IPI) P55854 (/IPI) P55854 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
 1 Q9Z172 (/ISO)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
 231 P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS)
(221 more)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
 142 P55854 (/IDA) P55854 (/IDA) P55854 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA)
(132 more)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
 47 P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO)
(37 more)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
 46 P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA)
(36 more)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
 46 P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO)
(36 more)
Positive regulation of protein sumoylation GO:0033235
Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein.
 46 P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA)
(36 more)
Positive regulation of protein sumoylation GO:0033235
Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein.
 46 P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO)
(36 more)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
 46 P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA) P61959 (/IDA)
(36 more)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
 46 P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO)
(36 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 46 P61959 (/IMP) P61959 (/IMP) P61959 (/IMP) P61959 (/IMP) P61959 (/IMP) P61959 (/IMP) P61959 (/IMP) P61959 (/IMP) P61959 (/IMP) P61959 (/IMP)
(36 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 46 P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO)
(36 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
 46 P61957 (/IGI) P61957 (/IGI) P61957 (/IGI) P61957 (/IGI) P61957 (/IGI) P61957 (/IGI) P61957 (/IGI) P61957 (/IGI) P61957 (/IGI) P61957 (/IGI)
(36 more)
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
 3 P55854 (/IDA) P55854 (/IDA) P55854 (/IDA)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
 2 Q6DHL4 (/IGI) Q6NV25 (/IGI)
Definitive hemopoiesis GO:0060216
A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.
 2 Q6DHL4 (/IGI) Q6NV25 (/IGI)
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
 1 Q9Z172 (/IDA)
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
 1 Q9Z172 (/ISO)
Positive regulation of ubiquitin-dependent protein catabolic process GO:2000060
Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
 1 Q9Z172 (/IDA)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
 276 P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS) P61955 (/ISS)
(266 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
 96 P55854 (/TAS) P55854 (/TAS) P55854 (/TAS) P61956 (/TAS) P61956 (/TAS) P61956 (/TAS) P61956 (/TAS) P61956 (/TAS) P61956 (/TAS) P61956 (/TAS)
(86 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 95 P55854 (/IDA) P55854 (/IDA) P55854 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA)
(85 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 47 P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO)
(37 more)
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
 46 P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA) P61956 (/IDA)
(36 more)
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
 46 P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO) P61957 (/ISO)
(36 more)
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
 3 P55854 (/TAS) P55854 (/TAS) P55854 (/TAS)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
 1 Q9Z172 (/IDA)