The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 207: Rhea, isoform B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 M9NDM3 (/IPI) M9PBW9 (/IPI) M9PEJ8 (/IPI) M9PF06 (/IPI) M9PF06 (/IPI) P0CE94 (/IPI) Q54K81 (/IPI) Q9VSL8 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
6 M9NDM3 (/IPI) M9PBW9 (/IPI) M9PEJ8 (/IPI) M9PF06 (/IPI) M9PF06 (/IPI) Q9VSL8 (/IPI)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
2 P0CE94 (/IDA) Q54K81 (/IDA)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
1 P0CE94 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q54K81 (/IDA)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoskeletal anchoring at plasma membrane GO:0007016
A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane.
6 M9NDM3 (/ISS) M9PBW9 (/ISS) M9PEJ8 (/ISS) M9PF06 (/ISS) M9PF06 (/ISS) Q9VSL8 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
6 M9NDM3 (/TAS) M9PBW9 (/TAS) M9PEJ8 (/TAS) M9PF06 (/TAS) M9PF06 (/TAS) Q9VSL8 (/TAS)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Germ-band shortening GO:0007390
The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo.
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Apposition of dorsal and ventral imaginal disc-derived wing surfaces GO:0007475
The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing.
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Maintenance of epithelial integrity, open tracheal system GO:0035160
Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process.
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Cardiac muscle cell-cardiac muscle cell adhesion GO:0086042
The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules.
6 M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP)
Actomyosin contractile ring contraction GO:0000916
The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle.
2 P0CE94 (/IMP) P0CE95 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 P0CE94 (/IMP)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
1 P0CE94 (/IMP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 P0CE94 (/IMP)
Terminal branching, open tracheal system GO:0007430
Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster.
1 Q9VSL8 (/HMP)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 P0CE94 (/IGI)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 Q54K81 (/IMP)
Cell-substrate adhesion GO:0031589
The attachment of a cell to the underlying substrate via adhesion molecules.
1 Q54K81 (/IGI)
Cell-substrate adhesion GO:0031589
The attachment of a cell to the underlying substrate via adhesion molecules.
1 P0CE94 (/IMP)
Uropod retraction GO:0034461
The process in which a uropod detaches from the cell substrate and retracts the rear of a migrating cell.
1 P0CE94 (/IMP)
Lumen formation, open tracheal system GO:0035149
Creation of the central hole of a tube in an open tracheal system through which gases flow.
1 Q9VSL8 (/HMP)
Cleavage furrow ingression GO:0036090
Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed.
1 P0CE94 (/IMP)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
1 Q54K81 (/IMP)
Autophagic cell death GO:0048102
A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
1 Q54K81 (/IMP)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
1 Q54K81 (/IMP)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
1 Q54K81 (/IDA)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 P0CE94 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
6 M9NDM3 (/IDA) M9PBW9 (/IDA) M9PEJ8 (/IDA) M9PF06 (/IDA) M9PF06 (/IDA) Q9VSL8 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
6 M9NDM3 (/ISS) M9PBW9 (/ISS) M9PEJ8 (/ISS) M9PF06 (/ISS) M9PF06 (/ISS) Q9VSL8 (/ISS)
Pseudopodium GO:0031143
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
2 P0CE94 (/IDA) Q54K81 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q54K81 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9VSL8 (/HDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q54K81 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P0CE94 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q9VSL8 (/HDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 Q54K81 (/IDA)
Cell trailing edge GO:0031254
The area of a motile cell opposite to the direction of movement.
1 P0CE94 (/IDA)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
1 P0CE94 (/IDA)
Filopodium tip GO:0032433
The end of a filopodium distal to the body of the cell.
1 P0CE94 (/IDA)