CATH Superfamily 3.10.20.90
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".
FunFam 143: E3 ubiquitin-protein ligase UHRF1 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 26 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q8VDF2 (/IPI) Q96T88 (/IPI) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q96T88 (/IDA) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q8VDF2 (/ISO) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q96T88 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q8VDF2 (/ISO) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q96T88 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q8VDF2 (/ISO) |
|
Methyl-CpG binding GO:0008327
Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.
|
1 | Q96T88 (/IDA) |
|
Methyl-CpG binding GO:0008327
Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.
|
1 | Q8VDF2 (/ISO) |
|
Nucleosomal histone binding GO:0031493
Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.
|
1 | Q8VDF2 (/IDA) |
|
Nucleosomal histone binding GO:0031493
Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.
|
1 | Q96T88 (/ISS) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
1 | Q8VDF2 (/ISO) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q96T88 (/IDA) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q8VDF2 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q8VDF2 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q96T88 (/ISS) |
|
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
|
1 | Q8VDF2 (/ISO) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q8VDF2 (/IDA) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q96T88 (/ISS) |
There are 33 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Maintenance of DNA methylation GO:0010216
Any process involved in maintaining the methylation state of a nucleotide sequence.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Maintenance of DNA methylation GO:0010216
Any process involved in maintaining the methylation state of a nucleotide sequence.
|
3 | E7EZF3 (/IMP) Q8VDF2 (/IMP) Q96T88 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q8VDF2 (/ISO) |
|
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
|
1 | E7EZF3 (/IGI) |
|
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
|
1 | E7EZF3 (/IMP) |
|
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
|
1 | E7EZF3 (/IMP) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | Q96T88 (/IDA) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | Q8VDF2 (/ISO) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | E7EZF3 (/IGI) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | E7EZF3 (/IMP) |
|
Maintenance of DNA methylation GO:0010216
Any process involved in maintaining the methylation state of a nucleotide sequence.
|
1 | Q8VDF2 (/ISO) |
|
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
1 | Q8VDF2 (/IDA) |
|
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
1 | Q96T88 (/ISS) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
1 | Q96T88 (/IDA) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
1 | Q8VDF2 (/ISO) |
|
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
|
1 | E7EZF3 (/IMP) |
|
Positive regulation of cellular protein metabolic process GO:0032270
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
|
1 | Q96T88 (/IDA) |
|
Positive regulation of cellular protein metabolic process GO:0032270
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
|
1 | Q8VDF2 (/ISO) |
|
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
1 | Q7TPK1 (/IEP) |
|
Hypermethylation of CpG island GO:0044027
An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.
|
1 | E7EZF3 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q96T88 (/IC) |
|
Regulation of epithelial cell proliferation GO:0050678
Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
|
1 | Q96T88 (/IMP) |
|
Regulation of epithelial cell proliferation GO:0050678
Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
|
1 | Q8VDF2 (/ISO) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | Q8VDF2 (/ISO) |
|
Intestinal epithelial structure maintenance GO:0060729
A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.
|
1 | E7EZF3 (/IGI) |
|
Intestinal epithelial structure maintenance GO:0060729
A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.
|
1 | E7EZF3 (/IMP) |
|
Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity GO:2000373
Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity.
|
1 | Q96T88 (/IC) |
There are 23 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q96T88 (/ISS) |
|
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
|
6 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) Q8VDF2 (/ISS) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
5 | A7E320 (/ISS) B6CHA3 (/ISS) E7EZF3 (/ISS) F6UA42 (/ISS) Q7TPK1 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | A0A087WTW0 (/IDA) A0A087WVR3 (/IDA) Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
2 | Q8VDF2 (/IDA) Q96T88 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q8VDF2 (/ISO) |
|
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
|
1 | Q96T88 (/IDA) |
|
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
|
1 | Q8VDF2 (/ISO) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
1 | Q8VDF2 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8VDF2 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8VDF2 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q8VDF2 (/TAS) |
|
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
1 | Q8VDF2 (/ISO) |
|
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
|
1 | Q8VDF2 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q7TPK1 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8VDF2 (/ISO) |
|
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
1 | Q8VDF2 (/IDA) |
|
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
1 | Q96T88 (/ISS) |
|
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | Q7TPK1 (/IDA) |
|
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | Q8VDF2 (/ISO) |