CATH Superfamily 3.10.20.90
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".
FunFam 108: Elongin-B
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
O44226 (/IPI)
O44226 (/IPI)
O44226 (/IPI)
O44226 (/IPI)
P62869 (/IPI)
P62869 (/IPI)
P62869 (/IPI)
Q15370 (/IPI)
Q15370 (/IPI)
Q15370 (/IPI)
(3 more) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
6 | Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | P62870 (/IDA) P62870 (/IDA) P62870 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | P62869 (/ISO) P62869 (/ISO) P62869 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
3 | P62870 (/IPI) P62870 (/IPI) P62870 (/IPI) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
3 | P62869 (/ISO) P62869 (/ISO) P62869 (/ISO) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
6 | Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) |
|
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
6 | Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
6 | Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) |
|
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
6 | Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) |
|
Regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
|
6 | Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) |
|
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
6 | Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) |
|
Imaginal disc-derived wing vein specification GO:0007474
The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
|
4 | O44226 (/IGI) O44226 (/IGI) O44226 (/IGI) O44226 (/IGI) |
|
Imaginal disc-derived wing vein specification GO:0007474
The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
|
4 | O44226 (/IMP) O44226 (/IMP) O44226 (/IMP) O44226 (/IMP) |
|
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
|
4 | O44226 (/IEP) O44226 (/IEP) O44226 (/IEP) O44226 (/IEP) |
|
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
|
4 | O44226 (/IMP) O44226 (/IMP) O44226 (/IMP) O44226 (/IMP) |
|
Negative regulation of receptor signaling pathway via JAK-STAT GO:0046426
Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT.
|
4 | O44226 (/IMP) O44226 (/IMP) O44226 (/IMP) O44226 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | P62870 (/IDA) P62870 (/IDA) P62870 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | P62869 (/ISO) P62869 (/ISO) P62869 (/ISO) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Elongin complex GO:0070449
A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits.
|
7 | O44226 (/IDA) O44226 (/IDA) O44226 (/IDA) O44226 (/IDA) P62869 (/IDA) P62869 (/IDA) P62869 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
6 | Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) Q15370 (/TAS) |
|
Cul2-RING ubiquitin ligase complex GO:0031462
A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
|
6 | Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) |
|
Cul5-RING ubiquitin ligase complex GO:0031466
A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
|
6 | Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) Q15370 (/IDA) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
3 | P62870 (/IDA) P62870 (/IDA) P62870 (/IDA) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
3 | P62869 (/ISO) P62869 (/ISO) P62869 (/ISO) |
|
VCB complex GO:0030891
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
|
3 | P62870 (/IDA) P62870 (/IDA) P62870 (/IDA) |
|
VCB complex GO:0030891
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
|
3 | P62869 (/ISO) P62869 (/ISO) P62869 (/ISO) |