The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"ASAP complex, SAP18 subunit
".
FunFam 1: Histone deacetylase complex subunit SAP18
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
26 |
O00422 (/IPI)
O00422 (/IPI)
O00422 (/IPI)
O00422 (/IPI)
O00422 (/IPI)
O00422 (/IPI)
O55128 (/IPI)
O55128 (/IPI)
O55128 (/IPI)
O64644 (/IPI)
(16 more) |
|
Beta-galactosidase activity GO:0004565
Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
|
12 |
Q90ZH5 (/IDA)
Q90ZH5 (/IDA)
Q90ZH5 (/IDA)
Q90ZH5 (/IDA)
Q90ZH5 (/IDA)
Q90ZH5 (/IDA)
Q90ZH5 (/IDA)
Q90ZH5 (/IDA)
Q90ZH5 (/IDA)
Q90ZH5 (/IDA)
(2 more) |
|
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
|
12 |
Q90ZH5 (/IPI)
Q90ZH5 (/IPI)
Q90ZH5 (/IPI)
Q90ZH5 (/IPI)
Q90ZH5 (/IPI)
Q90ZH5 (/IPI)
Q90ZH5 (/IPI)
Q90ZH5 (/IPI)
Q90ZH5 (/IPI)
Q90ZH5 (/IPI)
(2 more) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
6 | O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
6 | O00422 (/HDA) O00422 (/HDA) O00422 (/HDA) O00422 (/HDA) O00422 (/HDA) O00422 (/HDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
3 | Q9VEX9 (/IGI) Q9VEX9 (/IGI) Q9VEX9 (/IGI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
3 | Q9VEX9 (/IPI) Q9VEX9 (/IPI) Q9VEX9 (/IPI) |
There are 17 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
11 |
O55128 (/ISS)
O55128 (/ISS)
O55128 (/ISS)
Q3T022 (/ISS)
Q3T022 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
(1 more) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
11 |
O55128 (/ISS)
O55128 (/ISS)
O55128 (/ISS)
Q3T022 (/ISS)
Q3T022 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
(1 more) |
|
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
|
11 |
O55128 (/ISS)
O55128 (/ISS)
O55128 (/ISS)
Q3T022 (/ISS)
Q3T022 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
(1 more) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
6 | O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
6 | O00422 (/IMP) O00422 (/IMP) O00422 (/IMP) O00422 (/IMP) O00422 (/IMP) O00422 (/IMP) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
6 | O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
6 | O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) |
|
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
|
6 | O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) |
|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
3 | Q9VEX9 (/IC) Q9VEX9 (/IC) Q9VEX9 (/IC) |
|
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
3 | Q9VEX9 (/IGI) Q9VEX9 (/IGI) Q9VEX9 (/IGI) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | O55128 (/ISO) O55128 (/ISO) O55128 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q9VEX9 (/IDA) Q9VEX9 (/IDA) Q9VEX9 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q9VEX9 (/IGI) Q9VEX9 (/IGI) Q9VEX9 (/IGI) |
|
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
2 | O64644 (/IMP) O64644 (/IMP) |
|
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
|
2 | O64644 (/IEP) O64644 (/IEP) |
|
Histone modification GO:0016570
The covalent alteration of one or more amino acid residues within a histone protein.
|
1 | O94405 (/NAS) |
|
MRNA cis splicing, via spliceosome GO:0045292
The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
|
1 | O94405 (/ISS) |
There are 23 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
11 |
O55128 (/ISS)
O55128 (/ISS)
O55128 (/ISS)
Q3T022 (/ISS)
Q3T022 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
(1 more) |
|
ASAP complex GO:0061574
A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.
|
11 |
O55128 (/ISS)
O55128 (/ISS)
O55128 (/ISS)
Q3T022 (/ISS)
Q3T022 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
Q5RDT5 (/ISS)
(1 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
9 | O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O55128 (/TAS) O55128 (/TAS) O55128 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
8 | H7BZW6 (/IDA) H7BZW6 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
8 | H7BZW6 (/IDA) H7BZW6 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
8 | H7BZW6 (/IDA) H7BZW6 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) |
|
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
6 | O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) O00422 (/TAS) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
6 | O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) |
|
ASAP complex GO:0061574
A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.
|
6 | O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) O00422 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
5 | E9Q317 (/ISO) E9Q317 (/ISO) O55128 (/ISO) O55128 (/ISO) O55128 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | E9Q317 (/ISO) E9Q317 (/ISO) O55128 (/ISO) O55128 (/ISO) O55128 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
5 | E9Q317 (/ISO) E9Q317 (/ISO) O55128 (/ISO) O55128 (/ISO) O55128 (/ISO) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
5 | E9Q317 (/ISO) E9Q317 (/ISO) O55128 (/ISO) O55128 (/ISO) O55128 (/ISO) |
|
ASAP complex GO:0061574
A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.
|
5 | E9Q317 (/ISO) E9Q317 (/ISO) O55128 (/ISO) O55128 (/ISO) O55128 (/ISO) |
|
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
3 | O55128 (/ISO) O55128 (/ISO) O55128 (/ISO) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
3 | O55128 (/ISO) O55128 (/ISO) O55128 (/ISO) |
|
Sin3 complex GO:0016580
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
|
3 | Q9VEX9 (/ISS) Q9VEX9 (/ISS) Q9VEX9 (/ISS) |
|
Precatalytic spliceosome GO:0071011
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
|
3 | Q9VEX9 (/HDA) Q9VEX9 (/HDA) Q9VEX9 (/HDA) |
|
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
|
3 | Q9VEX9 (/HDA) Q9VEX9 (/HDA) Q9VEX9 (/HDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
2 | O64644 (/IDA) O64644 (/IDA) |
|
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
1 | O94405 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O94405 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O94405 (/HDA) |