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CATH Superfamily 3.10.120.10

Cytochrome b5-like heme/steroid binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome b5-like heme/steroid binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Sulfite oxidase, mitochondrial

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sulfite oxidase. [EC: 1.8.3.1]
Sulfite + O(2) + H(2)O = sulfate + H(2)O(2).
    		 9 A0A024RB79 A0A024RB79 P07850 P51687 P51687 Q07116 Q60HD0 Q8R086 Q9VWP4
    Acyl-lipid (7-3)-desaturase. [EC: 1.14.19.31]
    (1) A (7Z,10Z,13Z,16Z,19Z)-docosa-7,10,13,16,19-pentaenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (4Z,7Z,10Z,13Z,16Z,19Z)- docosa-4,7,10,13,16,19-hexaenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. (2) A (7Z,10Z,13Z,16Z)-docosa-7,10,13,16-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (4Z,7Z,10Z,13Z,16Z)-docosa- 4,7,10,13,16-pentaenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O.
    • The enzymes from several algae introduce a cis double bond at the 4-position in 22-carbon polyunsaturated fatty acids that contain a Delta(7) double bond.
    • The enzyme from the fresh water alga Chlamydomonas reinhardtii acts on the 16 carbon fatty acid (7Z,10Z,13Z)-hexadeca-7,10,13-trienoate.
    • The enzyme contains an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
    		 2 Q6WNG7 Q8S3C0
    Acyl-lipid (9-3)-desaturase. [EC: 1.14.19.47]
    (1) An alpha-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a stearidonoyl-[glycerolipid] + ferricytochrome b5 + 2 H(2)O. (2) A linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + 2 H(2)O.
    • The enzyme, characterized from the moss Physcomitrella patens and the plant Borago officinalis (borage), introduces a cis double bond at carbon 6 of several acyl-lipids that contain an existing Delta(9) cis double bond.
    • The enzyme contains a cytochrome b5 domain that acts as the electron donor for the active site of the desaturase.
    		 1 Q9LEM9