The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Cytochrome b5-like heme/steroid binding domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 52: Sphingolipid 10-desaturase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sphingolipid 10-desaturase. [EC:]
A (4E,8E)-sphinga-4,8-dienine ceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (4E,8E,10E)-sphinga-4,8,10-trienine ceramide + 2 ferricytochrome b5 + 2 H(2)O.
  • The enzyme, characterized from the marine diatom Thalassiosira pseudonana, produces an all-trans product.
  • Similar triunsaturated sphingoid bases are found in some marine invertebrates.
  • The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase.
1 Q4G2T3