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CATH Superfamily 3.10.120.10

Cytochrome b5-like heme/steroid binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome b5-like heme/steroid binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43: Potential delta(6)-or delta(8)-desaturase, putativ...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sphingolipid 8-(E)-desaturase. [EC: 1.14.19.18]
A (4E)-sphing-4-enine ceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (4E,8E)-sphing-4,8-dienine ceramide + 2 ferricytochrome b5 + 2 H(2)O.
  • The enzyme, characterized from the yeasts Kluyveromyces lactis and Candida albicans and from the diatom Thalassiosira pseudonana, introduces a trans double bond at the 8-position of sphingoid bases in sphingolipids.
  • The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase.
  • The homologous enzymes from higher plants, EC 1.14.19.29, act on phytosphinganine (4-hydroxysphinganine) and produces a mixture of trans and cis isomers.
 1 Q5AEK8