The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 52: Interleukin 33

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
3 O95760 (/IDA) O95760 (/IDA) Q8BVZ5 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O95760 (/IPI) O95760 (/IPI)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
1 Q8BVZ5 (/IPI)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
1 Q8BVZ5 (/ISO)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of macrophage activation GO:0043032
Any process that stimulates, induces or increases the rate of macrophage activation.
3 O95760 (/IDA) O95760 (/IDA) Q8BVZ5 (/IDA)
Positive regulation of chemokine secretion GO:0090197
Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell.
3 O95760 (/IDA) O95760 (/IDA) Q8BVZ5 (/IDA)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
2 O95760 (/TAS) O95760 (/TAS)
Interleukin-33-mediated signaling pathway GO:0038172
A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 O95760 (/TAS) O95760 (/TAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O95760 (/ISS) O95760 (/ISS)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
2 O95760 (/ISS) O95760 (/ISS)
Positive regulation of neuroinflammatory response GO:0150078
Any process that activates or increases the frequency, rate or extent of neuroinflammatory response.
2 O95760 (/TAS) O95760 (/TAS)
Macrophage activation involved in immune response GO:0002281
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
1 Q8BVZ5 (/IDA)
Microglial cell activation involved in immune response GO:0002282
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
1 Q8BVZ5 (/IDA)
Negative regulation of leukocyte migration GO:0002686
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.
1 Q8BVZ5 (/IGI)
Negative regulation of T-helper 1 type immune response GO:0002826
Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.
1 Q8BVZ5 (/IGI)
Positive regulation of type 2 immune response GO:0002830
Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
1 Q8BVZ5 (/IDA)
Positive regulation of type 2 immune response GO:0002830
Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
1 Q8BVZ5 (/IGI)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8BVZ5 (/IDA)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q8BVZ5 (/IDA)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q8BVZ5 (/IGI)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q8BVZ5 (/IGI)
Positive regulation of interleukin-13 production GO:0032736
Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.
1 Q8BVZ5 (/IGI)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
1 Q8BVZ5 (/IGI)
Positive regulation of interleukin-5 production GO:0032754
Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.
1 Q8BVZ5 (/IGI)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
1 Q8BVZ5 (/IGI)
Positive regulation of macrophage activation GO:0043032
Any process that stimulates, induces or increases the rate of macrophage activation.
1 Q8BVZ5 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8BVZ5 (/IDA)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
1 Q8BVZ5 (/IDA)
Positive regulation of immunoglobulin secretion GO:0051024
Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
1 Q8BVZ5 (/IGI)
Negative regulation of immunoglobulin secretion GO:0051025
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
1 Q8BVZ5 (/IGI)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 Q8BVZ5 (/IDA)
Microglial cell proliferation GO:0061518
The expansion of a microglial cell population by cell division.
1 Q8BVZ5 (/IDA)
Positive regulation of chemokine secretion GO:0090197
Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell.
1 Q8BVZ5 (/ISO)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
1 Q8BVZ5 (/IGI)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 O95760 (/TAS) O95760 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 O95760 (/TAS) O95760 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BVZ5 (/ISO)