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CATH Superfamily 2.70.98.20

Copper amine oxidase, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Copper amine oxidase, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Primary-amine oxidase. [EC: 1.4.3.21]
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
  • A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines.
  • They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
  • In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1).
  • Formerly EC 1.4.3.6.
 37 A0A070UZ51 A0A0E1M1G5 A0A0E2TNQ9 A0A350HMI0 A0A402RYN6 F4SI64 G0FF52 H0QJ58 H4UIN2 I2X534
(27 more...)
Diamine oxidase. [EC: 1.4.3.22]
Histamine + H(2)O + O(2) = (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2).
  • A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity toward secondary and tertiary amines.
  • They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 but unlike EC 1.4.3.4, they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
  • Formerly EC 1.4.3.6.
 7 A0A480JSR2 P19801 P36633 Q12556 Q59118 Q8JZQ5 Q9TRC7