The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel ligand-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 13: Acetylcholine receptor subunit alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
14 A0A0S0WNY8 (/ISS) A8JNX5 (/ISS) M9PDC9 (/ISS) O18394 (/ISS) O44202 (/ISS) P09478 (/ISS) P09478 (/ISS) P17644 (/ISS) P17644 (/ISS) P17644 (/ISS)
(4 more)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Synaptic transmission, cholinergic GO:0007271
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
7 P09478 (/IEP) P09478 (/IEP) P17644 (/IEP) P17644 (/IEP) P17644 (/IEP) P25162 (/IEP) P25162 (/IEP)
Cation transmembrane transport GO:0098655
The process in which a cation is transported across a membrane.
5 P09478 (/IDA) P09478 (/IDA) P17644 (/IDA) P17644 (/IDA) P17644 (/IDA)
Response to insecticide GO:0017085
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
4 P09478 (/IMP) P09478 (/IMP) P25162 (/IMP) P25162 (/IMP)
Sleep GO:0030431
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
4 A0A0S0WNY8 (/IMP) A8JNX5 (/IMP) M9PDC9 (/IMP) Q9NFR5 (/IMP)
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 O18394 (/IDA) O44202 (/IDA) Q9W3G6 (/IDA)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
14 A0A0S0WNY8 (/ISS) A8JNX5 (/ISS) M9PDC9 (/ISS) O18394 (/ISS) O44202 (/ISS) P09478 (/ISS) P09478 (/ISS) P17644 (/ISS) P17644 (/ISS) P17644 (/ISS)
(4 more)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
12 A0A0S0WNY8 (/IDA) A8JNX5 (/IDA) M9PDC9 (/IDA) O18394 (/IDA) O44202 (/IDA) P09478 (/IDA) P09478 (/IDA) P17644 (/IDA) P17644 (/IDA) P17644 (/IDA)
(2 more)
Acetylcholine-gated channel complex GO:0005892
A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
5 P09478 (/IPI) P09478 (/IPI) P17644 (/IPI) P17644 (/IPI) P17644 (/IPI)