CATH Superfamily 2.60.40.840

FunFam 1: beta-arrestin-1 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 75 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Protein binding GO:0005515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	14	C3PTE8 (/IPI) P17870 (/IPI) P29066 (/IPI) P29067 (/IPI) P32121 (/IPI) P32121 (/IPI) P32121 (/IPI) P49407 (/IPI) P49407 (/IPI) P49407 (/IPI) (4 more)
Ubiquitin protein ligase binding GO:0031625 Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.	7	P32121 (/IPI) P32121 (/IPI) P32121 (/IPI) P49407 (/IPI) P49407 (/IPI) P49407 (/IPI) P49407 (/IPI)
Angiotensin receptor binding GO:0031701 Interacting selectively and non-covalently with an angiotensin receptor.	7	P32121 (/IPI) P32121 (/IPI) P32121 (/IPI) P49407 (/IPI) P49407 (/IPI) P49407 (/IPI) P49407 (/IPI)
Arrestin family protein binding GO:1990763 Interacting selectively and non-covalently with any member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.	6	P29066 (/IPI) P29067 (/IPI) P49407 (/IPI) P49407 (/IPI) P49407 (/IPI) P49407 (/IPI)
Enzyme inhibitor activity GO:0004857 Binds to and stops, prevents or reduces the activity of an enzyme.	4	P49407 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS)
GTPase activator activity GO:0005096 Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.	4	P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
Signaling receptor binding GO:0005102 Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.	4	P29066 (/IPI) P32121 (/IPI) P32121 (/IPI) P32121 (/IPI)
Insulin-like growth factor receptor binding GO:0005159 Interacting selectively and non-covalently with the insulin-like growth factor receptor.	4	P49407 (/IPI) P49407 (/IPI) P49407 (/IPI) P49407 (/IPI)
Transcription factor binding GO:0008134 Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.	4	P49407 (/IPI) P49407 (/IPI) P49407 (/IPI) P49407 (/IPI)
Enzyme binding GO:0019899 Interacting selectively and non-covalently with any enzyme.	4	P29066 (/IPI) P32121 (/IPI) P32121 (/IPI) P32121 (/IPI)
Transcription regulatory region DNA binding GO:0044212 Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.	4	P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
G protein-coupled receptor binding GO:0001664 Interacting selectively and non-covalently with a G protein-coupled receptor.	3	P32121 (/IPI) P32121 (/IPI) P32121 (/IPI)
Signaling receptor binding GO:0005102 Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Enzyme binding GO:0019899 Interacting selectively and non-covalently with any enzyme.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Ubiquitin protein ligase binding GO:0031625 Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Alpha-1A adrenergic receptor binding GO:0031691 Interacting selectively and non-covalently with an alpha-1A adrenergic receptor.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Alpha-1B adrenergic receptor binding GO:0031692 Interacting selectively and non-covalently with an alpha-1B adrenergic receptor.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Angiotensin receptor binding GO:0031701 Interacting selectively and non-covalently with an angiotensin receptor.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Follicle-stimulating hormone receptor binding GO:0031762 Interacting selectively and non-covalently with a follicle-stimulating hormone receptor.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Molecular adaptor activity GO:0060090 The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.	3	P32121 (/IDA) P32121 (/IDA) P32121 (/IDA)
Arrestin family protein binding GO:1990763 Interacting selectively and non-covalently with any member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Inositol hexakisphosphate binding GO:0000822 Interacting selectively and non-covalently with inositol hexakisphosphate.	2	P17870 (/IDA) P32120 (/IDA)
G protein-coupled receptor binding GO:0001664 Interacting selectively and non-covalently with a G protein-coupled receptor.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.	2	P17870 (/IDA) P32120 (/IDA)
Protein domain specific binding GO:0019904 Interacting selectively and non-covalently with a specific domain of a protein.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Alpha-1A adrenergic receptor binding GO:0031691 Interacting selectively and non-covalently with an alpha-1A adrenergic receptor.	2	P29066 (/IPI) P29067 (/IPI)
Alpha-1B adrenergic receptor binding GO:0031692 Interacting selectively and non-covalently with an alpha-1B adrenergic receptor.	2	P29066 (/IDA) P29067 (/IDA)
Type 1 angiotensin receptor binding GO:0031702 Interacting selectively and non-covalently with a type 1 angiotensin receptor.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
D1 dopamine receptor binding GO:0031748 Interacting selectively and non-covalently with a D1 dopamine receptor.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Follicle-stimulating hormone receptor binding GO:0031762 Interacting selectively and non-covalently with a follicle-stimulating hormone receptor.	2	P29066 (/IPI) P29067 (/IPI)
Type 2A serotonin receptor binding GO:0031826 Interacting selectively and non-covalently with a type 2A serotonin receptor.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Platelet activating factor receptor binding GO:0031859 Interacting selectively and non-covalently with a platelet activating factor receptor.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Identical protein binding GO:0042802 Interacting selectively and non-covalently with an identical protein or proteins.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Protein kinase B binding GO:0043422 Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism.	2	Q91YI4 (/IPI) Q91YI4 (/IPI)
Protein-containing complex binding GO:0044877 Interacting selectively and non-covalently with a macromolecular complex.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Mitogen-activated protein kinase binding GO:0051019 Interacting selectively and non-covalently with a mitogen-activated protein kinase.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Molecular adaptor activity GO:0060090 The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
14-3-3 protein binding GO:0071889 Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
GTPase activator activity GO:0005096 Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.	1	Q8BWG8 (/ISO)
Insulin-like growth factor receptor binding GO:0005159 Interacting selectively and non-covalently with the insulin-like growth factor receptor.	1	Q8BWG8 (/ISO)
Transcription factor binding GO:0008134 Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.	1	Q8BWG8 (/ISO)
Protein domain specific binding GO:0019904 Interacting selectively and non-covalently with a specific domain of a protein.	1	P29067 (/IPI)
Clathrin binding GO:0030276 Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.	1	P29066 (/IDA)
Clathrin binding GO:0030276 Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.	1	P17870 (/IMP)
Clathrin binding GO:0030276 Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.	1	Q8BWG8 (/ISO)
Estrogen receptor binding GO:0030331 Interacting selectively and non-covalently with an estrogen receptor.	1	P29066 (/IPI)
Estrogen receptor binding GO:0030331 Interacting selectively and non-covalently with an estrogen receptor.	1	Q8BWG8 (/ISO)
Mitogen-activated protein kinase kinase binding GO:0031434 Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.	1	Q8BWG8 (/IDA)
Type 1 angiotensin receptor binding GO:0031702 Interacting selectively and non-covalently with a type 1 angiotensin receptor.	1	P29067 (/IPI)
D1 dopamine receptor binding GO:0031748 Interacting selectively and non-covalently with a D1 dopamine receptor.	1	P29067 (/IPI)
Type 2A serotonin receptor binding GO:0031826 Interacting selectively and non-covalently with a type 2A serotonin receptor.	1	P29067 (/IPI)
Platelet activating factor receptor binding GO:0031859 Interacting selectively and non-covalently with a platelet activating factor receptor.	1	P29067 (/IPI)
V2 vasopressin receptor binding GO:0031896 Interacting selectively and non-covalently with a V2 vasopressin receptor.	1	P29066 (/IDA)
V2 vasopressin receptor binding GO:0031896 Interacting selectively and non-covalently with a V2 vasopressin receptor.	1	Q8BWG8 (/ISO)
Clathrin heavy chain binding GO:0032050 Interacting selectively and non-covalently with a clathrin heavy chain.	1	P17870 (/IPI)
Acetylcholine receptor binding GO:0033130 Interacting selectively and non-covalently with an acetylcholine receptor.	1	P17870 (/IPI)
Phosphatidylinositol binding GO:0035091 Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.	1	P32120 (/IMP)
AP-2 adaptor complex binding GO:0035612 Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).	1	P29066 (/IDA)
AP-2 adaptor complex binding GO:0035612 Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).	1	P17870 (/IMP)
AP-2 adaptor complex binding GO:0035612 Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).	1	Q8BWG8 (/ISO)
Clathrin adaptor activity GO:0035615 Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles.	1	P29066 (/IDA)
Clathrin adaptor activity GO:0035615 Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles.	1	Q8BWG8 (/ISO)
Identical protein binding GO:0042802 Interacting selectively and non-covalently with an identical protein or proteins.	1	P29067 (/IPI)
Protein homodimerization activity GO:0042803 Interacting selectively and non-covalently with an identical protein to form a homodimer.	1	P17870 (/IMP)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.	1	Q8BWG8 (/IMP)
Transcription regulatory region DNA binding GO:0044212 Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.	1	Q8BWG8 (/ISO)
Ion channel binding GO:0044325 Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.	1	P29066 (/IPI)
Ion channel binding GO:0044325 Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.	1	Q8BWG8 (/ISO)
Protein-containing complex binding GO:0044877 Interacting selectively and non-covalently with a macromolecular complex.	1	P29067 (/IDA)
Protein phosphorylated amino acid binding GO:0045309 Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein.	1	P29066 (/IDA)
Protein phosphorylated amino acid binding GO:0045309 Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein.	1	Q8BWG8 (/ISO)
Mitogen-activated protein kinase binding GO:0051019 Interacting selectively and non-covalently with a mitogen-activated protein kinase.	1	P29067 (/IPI)
Phosphoprotein binding GO:0051219 Interacting selectively and non-covalently with a phosphorylated protein.	1	P29066 (/IPI)
Phosphoprotein binding GO:0051219 Interacting selectively and non-covalently with a phosphorylated protein.	1	Q8BWG8 (/ISO)
14-3-3 protein binding GO:0071889 Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.	1	P29067 (/IDA)

There are 153 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Positive regulation of receptor internalization GO:0002092 Any process that activates or increases the frequency, rate or extent of receptor internalization.	12	P17870 (/ISS) P29066 (/ISS) P32120 (/ISS) Q4R562 (/ISS) Q4R562 (/ISS) Q5RCR4 (/ISS) Q5RCR4 (/ISS) Q5RCR4 (/ISS) Q8BWG8 (/ISS) Q91YI4 (/ISS) (2 more)
Positive regulation of protein phosphorylation GO:0001934 Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.	8	P29066 (/IMP) P29067 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) Q91YI4 (/IMP) Q91YI4 (/IMP)
Positive regulation of receptor internalization GO:0002092 Any process that activates or increases the frequency, rate or extent of receptor internalization.	8	P29067 (/IMP) P32121 (/IMP) P32121 (/IMP) P32121 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
G protein-coupled receptor internalization GO:0002031 The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.	7	P32121 (/IMP) P32121 (/IMP) P32121 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186 A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).	7	P32121 (/TAS) P32121 (/TAS) P32121 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS)
Protein ubiquitination GO:0016567 The process in which one or more ubiquitin groups are added to a protein.	7	P32121 (/IMP) P32121 (/IMP) P32121 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
Platelet activation GO:0030168 A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.	7	P32121 (/TAS) P32121 (/TAS) P32121 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS)
Negative regulation of protein ubiquitination GO:0031397 Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.	7	P32121 (/IDA) P32121 (/IDA) P32121 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Negative regulation of NF-kappaB transcription factor activity GO:0032088 Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.	7	P32121 (/IDA) P32121 (/IDA) P32121 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.	7	P32121 (/IMP) P32121 (/IMP) P32121 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
Membrane organization GO:0061024 A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.	7	P32121 (/TAS) P32121 (/TAS) P32121 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374 Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.	7	P32121 (/IDA) P32121 (/IDA) P32121 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Positive regulation of protein phosphorylation GO:0001934 Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.	6	P17870 (/ISS) P29066 (/ISS) Q4R562 (/ISS) Q4R562 (/ISS) Q8BWG8 (/ISS) Q95223 (/ISS)
Ubiquitin-dependent protein catabolic process GO:0006511 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.	6	P17870 (/ISS) P29066 (/ISS) Q4R562 (/ISS) Q4R562 (/ISS) Q8BWG8 (/ISS) Q95223 (/ISS)
Negative regulation of Notch signaling pathway GO:0045746 Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.	6	C3PTE8 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) Q8BWG8 (/IMP)
Negative regulation of Notch signaling pathway GO:0045746 Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.	6	P17870 (/ISS) P29066 (/ISS) Q4R562 (/ISS) Q4R562 (/ISS) Q8BWG8 (/ISS) Q95223 (/ISS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374 Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.	6	P29066 (/IMP) P29067 (/IMP) P32121 (/IMP) P32121 (/IMP) P32121 (/IMP) Q8BWG8 (/IMP)
Regulation of receptor recycling GO:0001919 Any process that modulates the frequency, rate, or extent of receptor recycling.	5	A0A286YBG8 (/IGI) C3PTE8 (/IGI) F1QLG1 (/IGI) Q6PFK2 (/IGI) Q7T2D2 (/IGI)
G protein-coupled receptor internalization GO:0002031 The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.	5	P17870 (/TAS) P32120 (/TAS) P32121 (/TAS) P32121 (/TAS) P32121 (/TAS)
Ubiquitin-dependent protein catabolic process GO:0006511 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.	5	P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) Q8BWG8 (/IMP)
Regulation of chemokine activity GO:1900136 Any process that modulates the frequency, rate or extent of chemokine activity.	5	A0A286YBG8 (/IGI) C3PTE8 (/IGI) F1QLG1 (/IGI) Q6PFK2 (/IGI) Q7T2D2 (/IGI)
Desensitization of G protein-coupled receptor signaling pathway by arrestin GO:0002032 The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins.	4	P29067 (/IMP) P32121 (/IMP) P32121 (/IMP) P32121 (/IMP)
Transcription by RNA polymerase II GO:0006366 The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).	4	P29066 (/IDA) P32121 (/IDA) P32121 (/IDA) P32121 (/IDA)
Transcription by RNA polymerase II GO:0006366 The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).	4	P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
Negative regulation of interleukin-6 production GO:0032715 Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.	4	P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Negative regulation of interleukin-8 production GO:0032717 Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production.	4	P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Positive regulation of Rho protein signal transduction GO:0035025 Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.	4	P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
Positive regulation of histone acetylation GO:0035066 Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.	4	P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
Stress fiber assembly GO:0043149 The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.	4	P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	4	P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
Positive regulation of histone H4 acetylation GO:0090240 Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group.	4	P49407 (/IMP) P49407 (/IMP) P49407 (/IMP) P49407 (/IMP)
Negative regulation of protein phosphorylation GO:0001933 Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.	3	P29066 (/IMP) Q91YI4 (/IMP) Q91YI4 (/IMP)
Positive regulation of protein phosphorylation GO:0001934 Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
G protein-coupled receptor internalization GO:0002031 The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.	3	P32121 (/IDA) P32121 (/IDA) P32121 (/IDA)
G protein-coupled receptor internalization GO:0002031 The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Positive regulation of receptor internalization GO:0002092 Any process that activates or increases the frequency, rate or extent of receptor internalization.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Transcription by RNA polymerase II GO:0006366 The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Endocytosis GO:0006897 A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Transforming growth factor beta receptor signaling pathway GO:0007179 A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.	3	P32121 (/IDA) P32121 (/IDA) P32121 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186 A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Dopamine receptor signaling pathway GO:0007212 The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.	3	P32121 (/NAS) P32121 (/NAS) P32121 (/NAS)
Regulation of G protein-coupled receptor signaling pathway GO:0008277 Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.	3	Q8BWG8 (/IMP) Q91YI4 (/IMP) Q91YI4 (/IMP)
Regulation of G protein-coupled receptor signaling pathway GO:0008277 Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Protein ubiquitination GO:0016567 The process in which one or more ubiquitin groups are added to a protein.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Protein deubiquitination GO:0016579 The removal of one or more ubiquitin groups from a protein.	3	P32121 (/TAS) P32121 (/TAS) P32121 (/TAS)
Negative regulation of protein ubiquitination GO:0031397 Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Positive regulation of protein ubiquitination GO:0031398 Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.	3	P32121 (/IGI) P32121 (/IGI) P32121 (/IGI)
Positive regulation of protein ubiquitination GO:0031398 Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Receptor internalization GO:0031623 A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.	3	P32121 (/IDA) P32121 (/IDA) P32121 (/IDA)
Negative regulation of NF-kappaB transcription factor activity GO:0032088 Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Negative regulation of GTPase activity GO:0034260 Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Follicle-stimulating hormone signaling pathway GO:0042699 The series of molecular signals mediated by follicle-stimulating hormone.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Negative regulation of neuron apoptotic process GO:0043524 Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Negative regulation of natural killer cell mediated cytotoxicity GO:0045953 Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.	3	P32121 (/IMP) P32121 (/IMP) P32121 (/IMP)
Positive regulation of protein kinase B signaling GO:0051897 Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.	3	P29067 (/IMP) Q91YI4 (/IMP) Q91YI4 (/IMP)
Negative regulation of protein kinase B signaling GO:0051898 Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.	3	P32121 (/NAS) P32121 (/NAS) P32121 (/NAS)
Wnt signaling pathway, planar cell polarity pathway GO:0060071 The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.	3	P32121 (/TAS) P32121 (/TAS) P32121 (/TAS)
Excitatory postsynaptic potential GO:0060079 A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.	3	P32121 (/NAS) P32121 (/NAS) P32121 (/NAS)
Cell chemotaxis GO:0060326 The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).	3	P32121 (/IMP) P32121 (/IMP) P32121 (/IMP)
Regulation of androgen receptor signaling pathway GO:0060765 Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.	3	P32121 (/IDA) P32121 (/IDA) P32121 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374 Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Regulation of protein phosphorylation GO:0001932 Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.	2	Q91YI4 (/IDA) Q91YI4 (/IDA)
Regulation of protein phosphorylation GO:0001932 Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.	2	Q91YI4 (/IGI) Q91YI4 (/IGI)
Desensitization of G protein-coupled receptor signaling pathway GO:0002029 The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.	2	P17870 (/TAS) P32120 (/TAS)
Desensitization of G protein-coupled receptor signaling pathway by arrestin GO:0002032 The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Endocytosis GO:0006897 A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.	2	P29066 (/IDA) P29067 (/IDA)
Transforming growth factor beta receptor signaling pathway GO:0007179 A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
G protein-coupled receptor signaling pathway GO:0007186 A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).	2	P29066 (/IDA) P29067 (/IDA)
Adult walking behavior GO:0007628 The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.	2	Q91YI4 (/IMP) Q91YI4 (/IMP)
Regulation of G protein-coupled receptor signaling pathway GO:0008277 Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.	2	P29066 (/IDA) P29067 (/IDA)
Positive regulation of gene expression GO:0010628 Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	2	Q91YI4 (/IDA) Q91YI4 (/IDA)
Receptor internalization GO:0031623 A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Receptor internalization GO:0031623 A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.	2	P17870 (/TAS) P32120 (/TAS)
Positive regulation of synaptic transmission, dopaminergic GO:0032226 Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.	2	Q91YI4 (/IMP) Q91YI4 (/IMP)
Negative regulation of interleukin-1 beta production GO:0032691 Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.	2	Q91YI4 (/IMP) Q91YI4 (/IMP)
Negative regulation of interleukin-12 production GO:0032695 Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.	2	Q91YI4 (/IMP) Q91YI4 (/IMP)
Negative regulation of interleukin-6 production GO:0032715 Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.	2	Q91YI4 (/IMP) Q91YI4 (/IMP)
Negative regulation of tumor necrosis factor production GO:0032720 Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.	2	Q91YI4 (/IMP) Q91YI4 (/IMP)
Positive regulation of collagen biosynthetic process GO:0032967 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Positive regulation of peptidyl-serine phosphorylation GO:0033138 Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.	2	P29067 (/IMP) Q8BWG8 (/IMP)
Positive regulation of peptidyl-serine phosphorylation GO:0033138 Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Negative regulation of toll-like receptor signaling pathway GO:0034122 Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.	2	Q91YI4 (/IMP) Q91YI4 (/IMP)
Negative regulation of GTPase activity GO:0034260 Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.	2	P29066 (/IDA) P29067 (/IDA)
Negative regulation of smooth muscle cell apoptotic process GO:0034392 Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Follicle-stimulating hormone signaling pathway GO:0042699 The series of molecular signals mediated by follicle-stimulating hormone.	2	P29066 (/IDA) P29067 (/IDA)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.	2	P29067 (/IMP) Q8BWG8 (/IMP)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Negative regulation of neuron apoptotic process GO:0043524 Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.	2	P29066 (/IMP) P29067 (/IMP)
Positive regulation of protein kinase activity GO:0045860 Any process that activates or increases the frequency, rate or extent of protein kinase activity.	2	Q91YI4 (/IC) Q91YI4 (/IC)
Negative regulation of natural killer cell mediated cytotoxicity GO:0045953 Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Detection of temperature stimulus involved in sensory perception of pain GO:0050965 The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Positive regulation of protein kinase B signaling GO:0051897 Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Positive regulation of calcium ion transport GO:0051928 Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Cell chemotaxis GO:0060326 The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Regulation of androgen receptor signaling pathway GO:0060765 Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Negative regulation of release of cytochrome c from mitochondria GO:0090201 Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Positive regulation of epithelial cell apoptotic process GO:1904037 Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Positive regulation of DNA biosynthetic process GO:2000573 Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Positive regulation of cardiac muscle cell differentiation GO:2000727 Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.	2	Q91YI4 (/IDA) Q91YI4 (/IDA)
Activation of MAPK activity GO:0000187 The initiation of the activity of the inactive enzyme MAP kinase (MAPK).	1	P29066 (/IDA)
Activation of MAPK activity GO:0000187 The initiation of the activity of the inactive enzyme MAP kinase (MAPK).	1	Q8BWG8 (/ISO)
Negative regulation of protein phosphorylation GO:0001933 Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.	1	Q8BWG8 (/ISO)
Ubiquitin-dependent protein catabolic process GO:0006511 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.	1	Q8BWG8 (/ISO)
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).	1	P29066 (/TAS)
Brain development GO:0007420 The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).	1	P29067 (/IEP)
Muscle organ development GO:0007517 The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.	1	Q7T2D2 (/IMP)
Phototransduction GO:0007602 The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.	1	Q8BWG8 (/IMP)
Regulation of G protein-coupled receptor signaling pathway GO:0008277 Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.	1	P29066 (/TAS)
Positive regulation of cell population proliferation GO:0008284 Any process that activates or increases the rate or extent of cell proliferation.	1	P29066 (/IMP)
Positive regulation of cell population proliferation GO:0008284 Any process that activates or increases the rate or extent of cell proliferation.	1	Q8BWG8 (/ISO)
Regulation of smoothened signaling pathway GO:0008589 Any process that modulates the frequency, rate or extent of smoothened signaling.	1	Q7T2D2 (/IMP)
Sensory perception of pain GO:0019233 The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.	1	P29066 (/TAS)
Negative regulation of protein ubiquitination GO:0031397 Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.	1	P29067 (/IMP)
Positive regulation of protein ubiquitination GO:0031398 Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.	1	P29066 (/IMP)
Receptor internalization GO:0031623 A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.	1	P32120 (/IMP)
Positive regulation of protein binding GO:0032092 Any process that activates or increases the frequency, rate or extent of protein binding.	1	Q8BWG8 (/IMP)
Negative regulation of interleukin-6 production GO:0032715 Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.	1	Q8BWG8 (/ISO)
Negative regulation of interleukin-8 production GO:0032717 Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production.	1	Q8BWG8 (/ISO)
Positive regulation of collagen biosynthetic process GO:0032967 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.	1	P29067 (/IMP)
Negative regulation of smooth muscle cell apoptotic process GO:0034392 Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process.	1	P29067 (/IMP)
Positive regulation of smooth muscle cell apoptotic process GO:0034393 Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.	1	P29066 (/IMP)
Positive regulation of smooth muscle cell apoptotic process GO:0034393 Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.	1	Q8BWG8 (/ISO)
Positive regulation of Rho protein signal transduction GO:0035025 Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.	1	Q8BWG8 (/ISO)
Positive regulation of histone acetylation GO:0035066 Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.	1	Q8BWG8 (/ISO)
Embryonic hemopoiesis GO:0035162 The stages of blood cell formation that take place within the embryo.	1	C3PTE8 (/IMP)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.	1	Q8BWG8 (/IMP)
Response to drug GO:0042493 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.	1	P29066 (/IEP)
Regulation of apoptotic process GO:0042981 Any process that modulates the occurrence or rate of cell death by apoptotic process.	1	Q8BWG8 (/IMP)
Negative regulation of apoptotic process GO:0043066 Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.	1	P29066 (/IMP)
Negative regulation of apoptotic process GO:0043066 Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.	1	Q8BWG8 (/ISO)
Stress fiber assembly GO:0043149 The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.	1	Q8BWG8 (/ISO)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.	1	P29066 (/IMP)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.	1	Q8BWG8 (/ISO)
Negative regulation of Notch signaling pathway GO:0045746 Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.	1	C3PTE8 (/IGI)
Negative regulation of Notch signaling pathway GO:0045746 Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.	1	Q8BWG8 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	1	P29066 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	1	Q8BWG8 (/ISO)
Lateral mesoderm development GO:0048368 The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure.	1	C3PTE8 (/IMP)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.	1	P29067 (/IMP)
Detection of temperature stimulus involved in sensory perception of pain GO:0050965 The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.	1	P29067 (/IMP)
Sensory perception of touch GO:0050975 The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).	1	P29066 (/TAS)
Positive regulation of calcium ion transport GO:0051928 Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	1	P29067 (/IMP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373 Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.	1	P29066 (/IMP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373 Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.	1	Q8BWG8 (/ISO)
Clathrin-dependent endocytosis GO:0072583 An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.	1	P17870 (/IMP)
Negative regulation of release of cytochrome c from mitochondria GO:0090201 Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.	1	P29067 (/IMP)
Positive regulation of histone H4 acetylation GO:0090240 Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group.	1	Q8BWG8 (/ISO)
Endothelial to hematopoietic transition GO:0098508 The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium.	1	C3PTE8 (/IMP)
Regulation of microglial cell activation GO:1903978 Any process that modulates the frequency, rate or extent of microglial cell activation.	1	C3PTE8 (/IMP)
Positive regulation of epithelial cell apoptotic process GO:1904037 Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.	1	P29067 (/IMP)
Positive regulation of DNA biosynthetic process GO:2000573 Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.	1	P29067 (/IMP)

There are 39 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Cytoplasm GO:0005737 All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	10	P17870 (/IDA) P29066 (/IDA) P29067 (/IDA) P32121 (/IDA) P32121 (/IDA) P32121 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	10	P32121 (/TAS) P32121 (/TAS) P32121 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS) Q8BWG8 (/TAS) Q91YI4 (/TAS) Q91YI4 (/TAS)
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	8	P29066 (/IDA) P32121 (/IDA) P32121 (/IDA) P32121 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Plasma membrane GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	8	P29066 (/TAS) P32121 (/TAS) P32121 (/TAS) P32121 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS)
Cytoplasmic vesicle GO:0031410 A vesicle found in the cytoplasm of a cell.	8	P17870 (/IDA) P32121 (/IDA) P32121 (/IDA) P32121 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Cytoplasm GO:0005737 All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	7	P17870 (/ISS) P32120 (/ISS) Q5RCR4 (/ISS) Q5RCR4 (/ISS) Q5RCR4 (/ISS) Q91YI4 (/ISS) Q91YI4 (/ISS)
Endocytic vesicle GO:0030139 A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.	7	P29067 (/ISS) P32120 (/ISS) Q5RCR4 (/ISS) Q5RCR4 (/ISS) Q5RCR4 (/ISS) Q91YI4 (/ISS) Q91YI4 (/ISS)
Golgi membrane GO:0000139 The lipid bilayer surrounding any of the compartments of the Golgi apparatus.	4	P49407 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS)
Chromatin GO:0000785 The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.	4	P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Nucleoplasm GO:0005654 That part of the nuclear content other than the chromosomes or the nucleolus.	4	P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Lysosomal membrane GO:0005765 The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.	4	P49407 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS)
Plasma membrane GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	4	P17870 (/IDA) P32121 (/IDA) P32121 (/IDA) P32121 (/IDA)
Nuclear body GO:0016604 Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.	4	P49407 (/IDA) P49407 (/IDA) P49407 (/IDA) P49407 (/IDA)
Cytoplasmic vesicle membrane GO:0030659 The lipid bilayer surrounding a cytoplasmic vesicle.	4	P49407 (/TAS) P49407 (/TAS) P49407 (/TAS) P49407 (/TAS)
Intracellular membrane-bounded organelle GO:0043231 Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.	4	K7ENA6 (/IDA) P32121 (/IDA) P32121 (/IDA) P32121 (/IDA)
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Cytoplasm GO:0005737 All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Endosome GO:0005768 A vacuole to which materials ingested by endocytosis are delivered.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Postsynaptic density GO:0014069 An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Basolateral plasma membrane GO:0016323 The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Endocytic vesicle GO:0030139 A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.	3	P32121 (/IDA) P32121 (/IDA) P32121 (/IDA)
Cytoplasmic vesicle GO:0031410 A vesicle found in the cytoplasm of a cell.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Dendritic spine GO:0043197 A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Postsynaptic membrane GO:0045211 A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.	3	Q8BWG8 (/ISO) Q91YI4 (/ISO) Q91YI4 (/ISO)
Endosome GO:0005768 A vacuole to which materials ingested by endocytosis are delivered.	2	P29066 (/IDA) P29067 (/IDA)
Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	2	P29066 (/IDA) Q8BWG8 (/IDA)
Plasma membrane GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Postsynaptic density GO:0014069 An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.	2	P29066 (/IDA) P29067 (/IDA)
Basolateral plasma membrane GO:0016323 The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.	2	P29066 (/IDA) P29067 (/IDA)
Endocytic vesicle GO:0030139 A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Dendritic spine GO:0043197 A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.	2	P29066 (/IDA) P29067 (/IDA)
Intracellular membrane-bounded organelle GO:0043231 Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.	2	Q91YI4 (/ISO) Q91YI4 (/ISO)
Postsynaptic membrane GO:0045211 A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.	2	P29066 (/IDA) P29067 (/IDA)
Chromatin GO:0000785 The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.	1	Q8BWG8 (/ISO)
Nucleoplasm GO:0005654 That part of the nuclear content other than the chromosomes or the nucleolus.	1	Q8BWG8 (/ISO)
Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	1	Q8BWG8 (/ISO)
Nuclear body GO:0016604 Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.	1	Q8BWG8 (/ISO)
Clathrin coat of coated pit GO:0030132 The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.	1	P17870 (/IMP)
Pseudopodium GO:0031143 A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.	1	Q8BWG8 (/IDA)

Functional Families

There are 75 GO terms relating to "molecular function"

There are 153 GO terms relating to "biological process"

There are 39 GO terms relating to "cellular component"