The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cadherins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 98: cadherin-23 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q6QQE1 (/IPI) Q99PF4 (/IPI) Q9BYE9 (/IPI) Q9H251 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 Q9VFH5 (/ISM) Q9VGG5 (/ISM) Q9VGW1 (/ISM)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q8IGX4 (/IDA) Q9VVG0 (/IDA)
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
2 F1R7G8 (/IMP) Q6QQE1 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q8IGX4 (/IPI) Q9VVG0 (/IPI)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P58365 (/IPI)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q99PF4 (/ISO)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 Q9BYE9 (/IDA)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 E9Q7P9 (/ISO)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 E9Q7P9 (/ISS)

There are 52 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
6 Q8IGX4 (/ISS) Q99PF4 (/ISS) Q9VFH5 (/ISS) Q9VGG5 (/ISS) Q9VGW1 (/ISS) Q9VVG0 (/ISS)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
4 F1R7G8 (/IMP) Q6QQE1 (/IMP) Q99PF4 (/IMP) Q9H251 (/IMP)
Cell-cell adhesion mediated by cadherin GO:0044331
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
3 Q8IGX4 (/IDA) Q9BYE9 (/IDA) Q9VVG0 (/IDA)
Cell-cell adhesion mediated by cadherin GO:0044331
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
3 Q9VFH5 (/ISM) Q9VGG5 (/ISM) Q9VGW1 (/ISM)
Equilibrioception GO:0050957
The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion.
3 F1R7G8 (/IMP) Q6QQE1 (/IMP) Q9H251 (/IMP)
Inner ear receptor cell stereocilium organization GO:0060122
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.
3 F1R7G8 (/IMP) Q6QQE1 (/IMP) Q99PF4 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
2 F1R7G8 (/IMP) Q6QQE1 (/IMP)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
2 Q8IGX4 (/IDA) Q9VVG0 (/IDA)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
2 Q8IGX4 (/IDA) Q9VVG0 (/IDA)
Cell projection organization GO:0030030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
2 F1R7G8 (/IMP) Q6QQE1 (/IMP)
Hair cell differentiation GO:0035315
The process in which a relatively unspecialized cell acquires specialized features of a hair cell.
2 F1R7G8 (/IMP) Q6QQE1 (/IMP)
Neuromast hair cell morphogenesis GO:0035678
The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.
2 F1R7G8 (/IMP) Q6QQE1 (/IMP)
Dorsal appendage formation GO:0046843
Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration.
2 Q8IGX4 (/IDA) Q9VVG0 (/IDA)
Sensory perception of light stimulus GO:0050953
The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
2 Q99PF4 (/IMP) Q9H251 (/IMP)
Detection of mechanical stimulus involved in sensory perception GO:0050974
The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception.
2 F1R7G8 (/IMP) Q6QQE1 (/IMP)
Auditory receptor cell development GO:0060117
The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
2 F1R7G8 (/IMP) Q6QQE1 (/IMP)
Protein localization to cilium GO:0061512
A process in which a protein is transported to, or maintained in, a location within a cilium.
2 F1R7G8 (/IMP) Q6QQE1 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9H251 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q99PF4 (/ISO)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q99PF4 (/TAS)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
1 Q9VFH5 (/IGI)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 Q99PF4 (/IGI)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 Q99PF4 (/ISO)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 Q99PF4 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 Q9VGW1 (/IMP)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
1 Q9H251 (/NAS)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
1 Q9BYE9 (/IDA)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
1 E9Q7P9 (/ISO)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
1 E9Q7P9 (/ISS)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
1 Q9BYE9 (/IMP)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
1 E9Q7P9 (/ISO)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
1 E9Q7P9 (/ISS)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 Q99PF4 (/IMP)
Inner ear auditory receptor cell differentiation GO:0042491
The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell.
1 Q99PF4 (/IMP)
Cell-cell adhesion mediated by cadherin GO:0044331
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
1 E9Q7P9 (/ISO)
Cell-cell adhesion mediated by cadherin GO:0044331
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
1 E9Q7P9 (/ISS)
Photoreceptor cell maintenance GO:0045494
Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
1 Q9H251 (/IMP)
Photoreceptor cell maintenance GO:0045494
Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
1 Q99PF4 (/ISO)
Post-embryonic animal organ morphogenesis GO:0048563
Morphogenesis, during the post-embryonic phase, of an animal tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q99PF4 (/IMP)
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
1 Q99PF4 (/IMP)
Sensory perception of light stimulus GO:0050953
The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
1 Q99PF4 (/ISO)
Equilibrioception GO:0050957
The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion.
1 Q99PF4 (/ISO)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
1 Q9H251 (/IMP)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
1 Q99PF4 (/ISO)
Auditory receptor cell stereocilium organization GO:0060088
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.
1 Q99PF4 (/IGI)
Auditory receptor cell stereocilium organization GO:0060088
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.
1 Q99PF4 (/IMP)
Negative regulation of cell growth involved in contact inhibition GO:0060243
The negative regulation of cell growth in response to increased cell density.
1 Q9BYE9 (/IDA)
Negative regulation of cell growth involved in contact inhibition GO:0060243
The negative regulation of cell growth in response to increased cell density.
1 E9Q7P9 (/ISO)
Negative regulation of cell growth involved in contact inhibition GO:0060243
The negative regulation of cell growth in response to increased cell density.
1 E9Q7P9 (/ISS)
Intermicrovillar adhesion GO:0090675
The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.
1 Q9BYE9 (/IMP)
Intermicrovillar adhesion GO:0090675
The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.
1 E9Q7P9 (/ISO)
Intermicrovillar adhesion GO:0090675
The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.
1 E9Q7P9 (/ISS)

There are 32 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 Q8IGX4 (/ISS) Q9VFH5 (/ISS) Q9VGG5 (/ISS) Q9VGW1 (/ISS) Q9VVG0 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 Q8IGX4 (/IDA) Q9BYE9 (/IDA) Q9VVG0 (/IDA)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
2 Q8IGX4 (/IDA) Q9VVG0 (/IDA)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
2 F1R7G8 (/IDA) Q6QQE1 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 F1R7G8 (/ISS) Q6QQE1 (/ISS)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
1 Q99PF4 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q99PF4 (/IDA)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 Q9BYE9 (/IDA)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 E9Q7P9 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9H251 (/NAS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 E9Q7P9 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 E9Q7P9 (/ISS)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 Q9BYE9 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 E9Q7P9 (/ISO)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 E9Q7P9 (/ISS)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 Q9BYE9 (/IDA)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 E9Q7P9 (/ISO)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 E9Q7P9 (/ISS)
Stereocilium GO:0032420
An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.
1 Q99PF4 (/IDA)
Stereocilium GO:0032420
An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.
1 Q9H251 (/ISS)
Stereocilium tip GO:0032426
A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation.
1 Q99PF4 (/IDA)
Subapical complex GO:0035003
The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.
1 Q9VGW1 (/IDA)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
1 Q9BYE9 (/IDA)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
1 E9Q7P9 (/ISO)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
1 E9Q7P9 (/ISS)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 P58365 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q99PF4 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q99PF4 (/IDA)
Kinocilium GO:0060091
A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia.
1 Q99PF4 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9BYE9 (/HDA)
Cochlear hair cell ribbon synapse GO:0098683
A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density.
1 Q99PF4 (/IDA)
Photoreceptor ribbon synapse GO:0098684
A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.
1 Q99PF4 (/IDA)